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MSDS  : 1-alpha-H,5-alpha-H-Tropanium, 6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-, nitrate, (-)- tropate
CAS  : 6106-46-3
SYNONYMS  : * Mescomine * Methscopolamine nitrate * Methylscopolamine nitrate * N-Methylscopolammonium nitrate * Scopolamine methylnitrate * Skopolate * Skopyl * Viscope
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : YM3675150
CHEMICAL NAME : 1-alpha-H,5-alpha-H-Tropanium,
6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-,
nitrate, (-)- tropate
CAS REGISTRY NUMBER : 6106-46-3
LAST UPDATED : 199701
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C18-H24-N-O4.N-O3
MOLECULAR WEIGHT : 380.44
SYNONYMS/TRADE NAMES :
* Mescomine
* Methscopolamine nitrate
* Methylscopolamine nitrate
* N-Methylscopolammonium nitrate
* Scopolamine methylnitrate
* Skopolate
* Skopyl
* Viscope

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1864 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
1,42,1959

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 126 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80513
No. of Facilities: 68 (estimated)
No. of Industries: 1
No. of Occupations: 6
No. of Employees: 2770 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Tryptophan, 5-hydroxy-, DL-, pyrolyzateSUBSTANCE DEFINITION :Smoke condensate obtained by pyrolysis of 5-hydroxy-DL-tryptophanREFERENCE :CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:2,335,1977 114-03-4
Tryptophan, 5-hydroxy-, L- 4350-09-8
Tryptophan, 5-hydroxy- L- and(-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid, monohydrate 4350-09-8
Tryptophan, 5-hydroxy-, (L), mixed with sodiumnitrite 4350-09-8
Tryptophan, 5-methoxy- 2504-22-5
1-alpha-H,5-alpha-H-Tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-,nitrate, (-)- tropate 6106-46-3
L-Tryptophan, 1-methyl- 21339-55-9
Tryptophan, 5-methyl- 154-06-3
Tryptophan, 1-methyl-, DL-, mixed with sodium nitrite 154-06-3
Tryptophan, 7-nitro-, hydrochloride, DL- 74051-46-0
L-Tryptophan,2-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)hydrazide 84409-83-6
D-Tryptophan, N-(3-oxo-3-phenylpropyl)- 92515-11-2
D-Tryptophan, N-D-phenylalanyl- 58607-70-8
D-Tryptophan, N-L-phenylalanyl- 66421-20-3
L-Tryptophan, N-D-phenylalanyl- 76327-05-4
L-Tryptophan, N-L-phenylalanyl- 24587-41-5
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, benzoate(ester), cis- 102432-91-7
D-Tryptophan, N-D-phenylalanyl-, methyl ester,monohydrochloride 76327-08-7
Tryptophan mixed with sodium nitrite 76327-08-7
Tryptophan, D-, mixed with sodium nitrite 76327-08-7
Tryptophan, L-, mixed with sodium nitrite 76327-08-7
L-Tryptophan, N-(1-thioxoethyl)-, methyl ester 54774-15-1
Tryptophan, N-L-tryptophyl-, L-, pyrolyzate 54774-15-1
L-Tryptophan, L-tryptophyl-, mixed with sodiumnitrite 54774-15-1
Trysben R200-acid 54774-15-1
T-40517, sodium saltSUBSTANCE DEFINITION :Produced by S. hygroscopicus T-40517 (FERM-P 2366,ifo-13574)REFERENCE :JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-Volume(issue)/page/year: 30,77-82,1977 54774-15-1
Tsushimycin 11054-63-0
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, benzoate(ester), trans- 11054-63-0
Tuberactinomycin 11075-36-8
Tubermycin A, sodium salt 102646-67-3
Tuberosin-ISUBSTANCE DEFINITION :Isolated from Solanum tubersumREFERENCE :85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., BocaRaton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(Pt 1),108,1982 102646-67-3
Tubocuraranium,7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, diiodide, (1'-alpha)- 76786-15-7
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,dichloride, (1-beta)- 76786-17-9
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide 7601-55-0
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide, (1-beta)- 16240-52-1
Tubocurarine, (+)- 57-95-4
Tubocurarine, dichloride, (+)- 57-94-3
Tubocurarine, dichloride, pentahydrate, (+)- 6989-98-6
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, 2-hydroxy-2-phenylacetate (ester) 78371-76-3
Tubocurarine, O,O'-dimethyl-, (+)- 5152-30-7
TUCSUBSTANCE DEFINITION :Containing 5% methyl salicylate and 7.5% l-mentholREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 12,2153,1978 5152-30-7
TUHSUBSTANCE DEFINITION :Containing 5% methyl salicylate and 1.5% capsicum extractREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 12,2153,1978 5152-30-7
Tumescal-OP 5152-30-7
Tungsten 7440-33-7
Tungsten carbide 12070-12-1
Tungsten carbide, mixed with cobalt (85%15%) 11107-01-0
Tungsten carbide, mixed with cobalt (92%8%) 12718-69-3
Tungsten carbide, mixed with cobalt and titanium(78%:14%:8%) 37329-49-0
Tungsten chloride, (OC-6-11)- 13283-01-7
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide,alpha-phenylcyclohexaneacetate 102432-93-9

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