*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YO5100000
CHEMICAL NAME : Tubocurarine, dichloride, pentahydrate, (+)-
CAS REGISTRY NUMBER : 6989-98-6
LAST UPDATED : 199009
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C37-H41-N2-O6.Cl-H.Cl.5H2-O
MOLECULAR WEIGHT : 771.81
WISWESSER LINE NOTATION : T D6 I6 I-6 R6-18-66 D- D-- I-- R- 2AI- H& CO JK QO
B&K&T&&TT&J J1 J1 OO1 SQ B&1 B&1 G&O1 H&Q
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* d-Tubocurarine chloride pentahydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 150 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 93,109,1948
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 270 ug/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 97,19,1949
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 118,395,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 421 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
2,558,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 100,333,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 130 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 118,388,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 118,395,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 400 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 118,395,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 146 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 118,395,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 5280 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
2,558,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 840 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
2,558,1960
*** END OF RECORD ***
|
|
|
| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
Tryptophan, 5-hydroxy-, DL-, pyrolyzateSUBSTANCE DEFINITION :Smoke condensate obtained by pyrolysis of 5-hydroxy-DL-tryptophanREFERENCE :CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:2,335,1977
| 114-03-4 |
|
Tryptophan, 5-hydroxy-, L-
| 4350-09-8 |
|
Tryptophan, 5-hydroxy- L- and(-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid, monohydrate
| 4350-09-8 |
|
Tryptophan, 5-hydroxy-, (L), mixed with sodiumnitrite
| 4350-09-8 |
|
Tryptophan, 5-methoxy-
| 2504-22-5 |
|
1-alpha-H,5-alpha-H-Tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-,nitrate, (-)- tropate
| 6106-46-3 |
|
L-Tryptophan, 1-methyl-
| 21339-55-9 |
|
Tryptophan, 5-methyl-
| 154-06-3 |
|
Tryptophan, 1-methyl-, DL-, mixed with sodium nitrite
| 154-06-3 |
|
Tryptophan, 7-nitro-, hydrochloride, DL-
| 74051-46-0 |
|
L-Tryptophan,2-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)hydrazide
| 84409-83-6 |
|
D-Tryptophan, N-(3-oxo-3-phenylpropyl)-
| 92515-11-2 |
|
D-Tryptophan, N-D-phenylalanyl-
| 58607-70-8 |
|
D-Tryptophan, N-L-phenylalanyl-
| 66421-20-3 |
|
L-Tryptophan, N-D-phenylalanyl-
| 76327-05-4 |
|
L-Tryptophan, N-L-phenylalanyl-
| 24587-41-5 |
|
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, benzoate(ester), cis-
| 102432-91-7 |
|
D-Tryptophan, N-D-phenylalanyl-, methyl ester,monohydrochloride
| 76327-08-7 |
|
Tryptophan mixed with sodium nitrite
| 76327-08-7 |
|
Tryptophan, D-, mixed with sodium nitrite
| 76327-08-7 |
|
Tryptophan, L-, mixed with sodium nitrite
| 76327-08-7 |
|
L-Tryptophan, N-(1-thioxoethyl)-, methyl ester
| 54774-15-1 |
|
Tryptophan, N-L-tryptophyl-, L-, pyrolyzate
| 54774-15-1 |
|
L-Tryptophan, L-tryptophyl-, mixed with sodiumnitrite
| 54774-15-1 |
|
Trysben R200-acid
| 54774-15-1 |
|
T-40517, sodium saltSUBSTANCE DEFINITION :Produced by S. hygroscopicus T-40517 (FERM-P 2366,ifo-13574)REFERENCE :JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-Volume(issue)/page/year: 30,77-82,1977
| 54774-15-1 |
|
Tsushimycin
| 11054-63-0 |
|
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, benzoate(ester), trans-
| 11054-63-0 |
|
Tuberactinomycin
| 11075-36-8 |
|
Tubermycin A, sodium salt
| 102646-67-3 |
|
Tuberosin-ISUBSTANCE DEFINITION :Isolated from Solanum tubersumREFERENCE :85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., BocaRaton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(Pt 1),108,1982
| 102646-67-3 |
|
Tubocuraranium,7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, diiodide, (1'-alpha)-
| 76786-15-7 |
|
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,dichloride, (1-beta)-
| 76786-17-9 |
|
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide
| 7601-55-0 |
|
Tubocuraranium,6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-,diiodide, (1-beta)-
| 16240-52-1 |
|
Tubocurarine, (+)-
| 57-95-4 |
|
Tubocurarine, dichloride, (+)-
| 57-94-3 |
|
Tubocurarine, dichloride, pentahydrate, (+)-
| 6989-98-6 |
|
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide, 2-hydroxy-2-phenylacetate (ester)
| 78371-76-3 |
|
Tubocurarine, O,O'-dimethyl-, (+)-
| 5152-30-7 |
|
TUCSUBSTANCE DEFINITION :Containing 5% methyl salicylate and 7.5% l-mentholREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 12,2153,1978
| 5152-30-7 |
|
TUHSUBSTANCE DEFINITION :Containing 5% methyl salicylate and 1.5% capsicum extractREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 12,2153,1978
| 5152-30-7 |
|
Tumescal-OP
| 5152-30-7 |
|
Tungsten
| 7440-33-7 |
|
Tungsten carbide
| 12070-12-1 |
|
Tungsten carbide, mixed with cobalt (85%15%)
| 11107-01-0 |
|
Tungsten carbide, mixed with cobalt (92%8%)
| 12718-69-3 |
|
Tungsten carbide, mixed with cobalt and titanium(78%:14%:8%)
| 37329-49-0 |
|
Tungsten chloride, (OC-6-11)-
| 13283-01-7 |
|
1-alpha-H,5-alpha-H-Tropanium,8-(p-ethylbenzyl)-3-hydroxy-, bromide,alpha-phenylcyclohexaneacetate
| 102432-93-9 |
|
|