*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DF2100000
CHEMICAL NAME : 2-H-1,4-Benzodiazepin-2-one,
5-(o-chlorophenyl)-1,3-dihydro-7-nitro-
CAS REGISTRY NUMBER : 1622-61-3
OTHER CAS REGISTRY NOS. : 106955-87-7
BEILSTEIN REFERENCE NO. : 0759557
REFERENCE : 5-24-04-00351 (Beilstein Handbook Reference)
LAST UPDATED : 199706
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C15-H10-Cl-N3-O3
MOLECULAR WEIGHT : 315.73
WISWESSER LINE NOTATION : T67 GMV JN IHJ CNW KR BG
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Antelepsin
* Antilepsin
* 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one
* 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one
* 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one
* Clonazepam
* Clonopin
* 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one
* Iktorivil
* Klonopin
* Landsen
* Rivotril
* Ro 5-4023
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 21 mg/kg/26W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB
88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 63,311,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1329 ug/kg/31D-I
TOXIC EFFECTS :
Liver - liver function tests impaired
REFERENCE :
AJGAAR American Journal of Gastroenterology. (American College of
Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21-
1954- Volume(issue)/page/year: 83,576,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,235,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,811,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,235,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001,
00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 35,77,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 13300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,811,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,235,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 11,811,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7280 mg/kg/26W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in thyroid weight
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 4,1441,1976
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 1750 ug/kg
SEX/DURATION : female 14-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year:
44,493,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 3300 ug/kg
SEX/DURATION : female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
40,365,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 8 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
DGDFA5 Development, Growth & Differentiation. (Japan Pub. Trading Co.
(USA), 1255 Howard St., San Francisco, CA 94103) V.11- 1969-
Volume(issue)/page/year: 22,61,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 24 mg/kg
SEX/DURATION : female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 5,2457,1977
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5401
No. of Facilities: 46 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 998 (estimated)
No. of Female Employees: 546 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Body fluid assay; Host-mediated assay
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
3H-2,4-Benzodiazepine-1,5(2H,4H)-dione, 3-thioxo-
| 54871-40-8 |
1H-1,4-Benzodiazepine-2-ethanol,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-
| 112634-55-6 |
1H-1,4-Benzodiazepine-1-propanenitrile,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-2-oxo-
| 75696-02-5 |
1H-1,4-Benzodiazepine-7-sulfonamide,2,3-dihydro-N,N-dimethyl-2-oxo-5-phenyl-
| 33211-62-0 |
1H-1,4-Benzodiazepine-7-sulfonamide,2,3-dihydro-2-oxo-5-phenyl-
| 32224-64-9 |
1H-1,5-Benzodiazepine,2,3,4,5-tetrahydro-2,4-dimethyl-, cis-
| 58414-04-3 |
5H-Benzocyclohepten-6-amine,6,7,8,9-tetrahydro-N,6-dimethyl-, hydrochloride,(+-)-
| 56485-63-3 |
2H-1,4-Benzodiazepine-2-thione,7-chloro-1,3-dihydro-1-methyl-5-phenyl-
| 2898-13-7 |
2H-1,4-Benzodiazepine-2-thione,7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
| 36735-22-5 |
2H-1,5-Benzodiazepine-2-thione, 1,3-dihydro-4-phenyl-
| 41054-45-9 |
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-3-(2-hydroxyethyl)-
| 87744-52-3 |
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-3-(2-hydroxyethyl)-7-propoxy-
| 87744-99-8 |
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-7-methoxy-3-(2-methoxyethyl)-
| 87744-96-5 |
1H-1,5-Benzodiazepine-2-thione,2,3,4,5-tetrahydro-4-methyl-
| 74389-71-2 |
3H-2,4-Benzodiazepine-1,3,5(2H,4H)-trione, 7-nitro-
| 74389-71-2 |
3H-1,4-Benzodiazepin-3-ol,7-chloro-2-(dimethylamino)-5-phenyl-
| 76458-47-4 |
3H-1,4-Benzodiazepin-3-ol,7-chloro-2-(methylamino)-5-phenyl-
| 76458-47-4 |
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-, hydrochloride
| 62819-36-7 |
2H-1,4-Benzodiazepin-2-one,7-amino-1,3-dihydro-5-phenyl-
| 4928-02-3 |
2H-1,4-Benzodiazepin-2-one,7-bromo-5-(2-chlorophenyl)-1,3-dihydro-
| 51753-57-2 |
2H-1,4-Benzodiazepin-2-one,7-bromo-1,3-dihydro-5-(2-pyridyl)-
| 1812-30-2 |
2H-1,4-Benzodiazepin-2-one,7-bromo-1,3-dihydro-5-(2-pyridyl)-, nitrosated
| 104639-50-1 |
2H,1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
| 846-49-1 |
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-
| 14439-61-3 |
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(1-cyclohexen-1-yl)-1,3-dihydro-1-methyl-
| 10379-14-3 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-
| 25967-29-7 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, dihydrochloride
| 1172-18-5 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3- dihydro-, monohydrochloride
| 36105-20-1 |
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-5-(2-nitrophenoxy)-,monohydrochloride, cis-
| 72575-53-2 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hemisuccinyloxy-5-phenyl-,dimethylaminoethanol salt
| 16327-90-5 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-
| 846-50-4 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-
| 604-75-1 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-1-methyl-5-phenyl-
| 439-14-5 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-5-phenyl-
| 1088-11-5 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-5-phenyl-, 4-oxide
| 963-39-3 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-ethyl-
| 20378-80-7 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-methyl-
| 20430-79-9 |
3H-1,4-Benzodiazepin-2(1H)-one,8-chloro-5-ethoxy-1-methyl-
| 62903-63-3 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-phenyl-
| 20430-81-3 |
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-5-(4-nitrophenoxy)-,monohydrochloride, trans-
| 72575-49-6 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-(o-fluorophenoxy)-1-methyl-
| 62903-61-1 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-1-methyl-5-(2-propynyloxy)-
| 62903-59-7 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-1-methyl-5-(1-trifluoromethylethoxy)-
| 62903-57-5 |
2-H-1,4-Benzodiazepin-2-one,5-(o-chlorophenyl)-1,3-dihydro-7-nitro-
| 1622-61-3 |
2H-1,4-Benzodiazepin-2-one,7-chloro-5-phenyl-1,3,4,5-tetrahydro-
| 1824-69-7 |
1H-1,5-Benzodiazepin-2(3H)-one, 4,5-dihydro-5-acetyl-
| 1824-69-7 |
1H-1,5-Benzodiazepin-2(3H)-one,4,5-dihydro-1-acetyl-5-nitroso-
| 1824-69-7 |
1H-1,5-Benzodiazepin-2(3H)-one,4,5-dihydro-5-acetyl-1-propionyl-
| 1824-69-7 |
2H-1,5-Benzodiazepin-2-one,1,3-dihydro-4-amino-8-bromo-1-phenyl-
| 36985-34-9 |
2H-1,4-Benzodiazepin-2-one,1,3-dihydro-3-amino-7-chloro-5-phenyl-
| 894-77-9 |
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