*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DF0650000
CHEMICAL NAME : 2H-1,4-Benzodiazepin-2-one,
7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3
-dihydro-
CAS REGISTRY NUMBER : 25967-29-7
BEILSTEIN REFERENCE NO. : 0898682
REFERENCE : 5-24-04-00321 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C19-H16-Cl-F-N2-O
MOLECULAR WEIGHT : 342.82
WISWESSER LINE NOTATION : T67 GNV JN IHJ CG KR BF& G1- AL3TJ
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 2H-1,4-Benzodiazepin-2-one,
7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-1,3-dihydro-
* 7-Chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzo
diazepin-2-one
* Flutoprazepam
* ID-1937
* KB-509
* Restar
* Restas
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10060 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1055,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2230 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1055,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1005,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2430 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1055,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2110 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1055,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1005,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Gastrointestinal - nausea or vomiting
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1005,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : >4 gm/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1005,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1055,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 65520 mg/kg/13W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1061,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 136 gm/kg/27W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1061,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 2275 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - changes in uterine weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1105,1980
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 9800 mg/kg
SEX/DURATION : female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,1,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 11 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,13,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 110 mg/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,13,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2700 mg/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - physical
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 21,27,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 13 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 16,658,1982
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
3H-2,4-Benzodiazepine-1,5(2H,4H)-dione, 3-thioxo-
| 54871-40-8 |
|
1H-1,4-Benzodiazepine-2-ethanol,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-
| 112634-55-6 |
|
1H-1,4-Benzodiazepine-1-propanenitrile,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-2-oxo-
| 75696-02-5 |
|
1H-1,4-Benzodiazepine-7-sulfonamide,2,3-dihydro-N,N-dimethyl-2-oxo-5-phenyl-
| 33211-62-0 |
|
1H-1,4-Benzodiazepine-7-sulfonamide,2,3-dihydro-2-oxo-5-phenyl-
| 32224-64-9 |
|
1H-1,5-Benzodiazepine,2,3,4,5-tetrahydro-2,4-dimethyl-, cis-
| 58414-04-3 |
|
5H-Benzocyclohepten-6-amine,6,7,8,9-tetrahydro-N,6-dimethyl-, hydrochloride,(+-)-
| 56485-63-3 |
|
2H-1,4-Benzodiazepine-2-thione,7-chloro-1,3-dihydro-1-methyl-5-phenyl-
| 2898-13-7 |
|
2H-1,4-Benzodiazepine-2-thione,7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
| 36735-22-5 |
|
2H-1,5-Benzodiazepine-2-thione, 1,3-dihydro-4-phenyl-
| 41054-45-9 |
|
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-3-(2-hydroxyethyl)-
| 87744-52-3 |
|
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-3-(2-hydroxyethyl)-7-propoxy-
| 87744-99-8 |
|
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-7-methoxy-3-(2-methoxyethyl)-
| 87744-96-5 |
|
1H-1,5-Benzodiazepine-2-thione,2,3,4,5-tetrahydro-4-methyl-
| 74389-71-2 |
|
3H-2,4-Benzodiazepine-1,3,5(2H,4H)-trione, 7-nitro-
| 74389-71-2 |
|
3H-1,4-Benzodiazepin-3-ol,7-chloro-2-(dimethylamino)-5-phenyl-
| 76458-47-4 |
|
3H-1,4-Benzodiazepin-3-ol,7-chloro-2-(methylamino)-5-phenyl-
| 76458-47-4 |
|
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-, hydrochloride
| 62819-36-7 |
|
2H-1,4-Benzodiazepin-2-one,7-amino-1,3-dihydro-5-phenyl-
| 4928-02-3 |
|
2H-1,4-Benzodiazepin-2-one,7-bromo-5-(2-chlorophenyl)-1,3-dihydro-
| 51753-57-2 |
|
2H-1,4-Benzodiazepin-2-one,7-bromo-1,3-dihydro-5-(2-pyridyl)-
| 1812-30-2 |
|
2H-1,4-Benzodiazepin-2-one,7-bromo-1,3-dihydro-5-(2-pyridyl)-, nitrosated
| 104639-50-1 |
|
2H,1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
| 846-49-1 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-
| 14439-61-3 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(1-cyclohexen-1-yl)-1,3-dihydro-1-methyl-
| 10379-14-3 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-
| 25967-29-7 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, dihydrochloride
| 1172-18-5 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3- dihydro-, monohydrochloride
| 36105-20-1 |
|
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-5-(2-nitrophenoxy)-,monohydrochloride, cis-
| 72575-53-2 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hemisuccinyloxy-5-phenyl-,dimethylaminoethanol salt
| 16327-90-5 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-
| 846-50-4 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-
| 604-75-1 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-1-methyl-5-phenyl-
| 439-14-5 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-5-phenyl-
| 1088-11-5 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-5-phenyl-, 4-oxide
| 963-39-3 |
|
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-ethyl-
| 20378-80-7 |
|
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-methyl-
| 20430-79-9 |
|
3H-1,4-Benzodiazepin-2(1H)-one,8-chloro-5-ethoxy-1-methyl-
| 62903-63-3 |
|
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-phenyl-
| 20430-81-3 |
|
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-5-(4-nitrophenoxy)-,monohydrochloride, trans-
| 72575-49-6 |
|
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-(o-fluorophenoxy)-1-methyl-
| 62903-61-1 |
|
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-1-methyl-5-(2-propynyloxy)-
| 62903-59-7 |
|
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-1-methyl-5-(1-trifluoromethylethoxy)-
| 62903-57-5 |
|
2-H-1,4-Benzodiazepin-2-one,5-(o-chlorophenyl)-1,3-dihydro-7-nitro-
| 1622-61-3 |
|
2H-1,4-Benzodiazepin-2-one,7-chloro-5-phenyl-1,3,4,5-tetrahydro-
| 1824-69-7 |
|
1H-1,5-Benzodiazepin-2(3H)-one, 4,5-dihydro-5-acetyl-
| 1824-69-7 |
|
1H-1,5-Benzodiazepin-2(3H)-one,4,5-dihydro-1-acetyl-5-nitroso-
| 1824-69-7 |
|
1H-1,5-Benzodiazepin-2(3H)-one,4,5-dihydro-5-acetyl-1-propionyl-
| 1824-69-7 |
|
2H-1,5-Benzodiazepin-2-one,1,3-dihydro-4-amino-8-bromo-1-phenyl-
| 36985-34-9 |
|
2H-1,4-Benzodiazepin-2-one,1,3-dihydro-3-amino-7-chloro-5-phenyl-
| 894-77-9 |
|
|