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MSDS  : 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1- (2,2,2-trifluoroethyl)-
CAS  : 36735-22-5
SYNONYMS  : * Dormalin * Oniria * Prosedar * Quazepam * Quazium * Sch 16134 * Selepam
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DE9710000
CHEMICAL NAME : 2H-1,4-Benzodiazepine-2-thione,
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-
(2,2,2-trifluoroethyl)-
CAS REGISTRY NUMBER : 36735-22-5
BEILSTEIN REFERENCE NO. : 0901084
REFERENCE : 5-24-04-00356 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C17-H11-Cl-F4-N2-S
MOLECULAR WEIGHT : 386.81
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Dormalin
* Oniria
* Prosedar
* Quazepam
* Quazium
* Sch 16134
* Selepam

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 37,906,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2749 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 37,906,1987

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 32,1456,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 845 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - ptosis
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 37,906,1987

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 37,906,1987

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - analgesia
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 32,1456,1982

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 18 gm/kg/52W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 37,906,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 14 gm/kg/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - changes in ovarian weight
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 37,906,1987

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 90 mg/kg
SEX/DURATION : female 13-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 37,906,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 520 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 37,906,1987

*** END OF RECORD ***
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NAMECAS
3H-2,4-Benzodiazepine-1,5(2H,4H)-dione, 3-thioxo- 54871-40-8
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1H-1,4-Benzodiazepine-1-propanenitrile,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-2-oxo- 75696-02-5
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1H-1,4-Benzodiazepine-7-sulfonamide,2,3-dihydro-2-oxo-5-phenyl- 32224-64-9
1H-1,5-Benzodiazepine,2,3,4,5-tetrahydro-2,4-dimethyl-, cis- 58414-04-3
5H-Benzocyclohepten-6-amine,6,7,8,9-tetrahydro-N,6-dimethyl-, hydrochloride,(+-)- 56485-63-3
2H-1,4-Benzodiazepine-2-thione,7-chloro-1,3-dihydro-1-methyl-5-phenyl- 2898-13-7
2H-1,4-Benzodiazepine-2-thione,7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- 36735-22-5
2H-1,5-Benzodiazepine-2-thione, 1,3-dihydro-4-phenyl- 41054-45-9
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-3-(2-hydroxyethyl)- 87744-52-3
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-3-(2-hydroxyethyl)-7-propoxy- 87744-99-8
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-7-methoxy-3-(2-methoxyethyl)- 87744-96-5
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3H-1,4-Benzodiazepin-3-ol,7-chloro-2-(methylamino)-5-phenyl- 76458-47-4
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-, hydrochloride 62819-36-7
2H-1,4-Benzodiazepin-2-one,7-amino-1,3-dihydro-5-phenyl- 4928-02-3
2H-1,4-Benzodiazepin-2-one,7-bromo-5-(2-chlorophenyl)-1,3-dihydro- 51753-57-2
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2H-1,4-Benzodiazepin-2-one,7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl- 14439-61-3
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(1-cyclohexen-1-yl)-1,3-dihydro-1-methyl- 10379-14-3
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2H-1,4-Benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3- dihydro-, monohydrochloride 36105-20-1
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-5-(2-nitrophenoxy)-,monohydrochloride, cis- 72575-53-2
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2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl- 846-50-4
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hydroxy-5-phenyl- 604-75-1
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