*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DF0880000
CHEMICAL NAME : 2H-1,4-Benzodiazepin-2-one,
7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)
-1,3- dihydro-, monohydrochloride
CAS REGISTRY NUMBER : 36105-20-1
LAST UPDATED : 199210
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C21-H23-Cl-F-N3-O.Cl-H
MOLECULAR WEIGHT : 424.38
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Flurazepam monohydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 978 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 179 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 859 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 684 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 205 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,381,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 598 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 58 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,381,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 460 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13500 mg/kg/30D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21840 mg/kg/26W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,2820,1973
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
3H-2,4-Benzodiazepine-1,5(2H,4H)-dione, 3-thioxo-
| 54871-40-8 |
1H-1,4-Benzodiazepine-2-ethanol,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-
| 112634-55-6 |
1H-1,4-Benzodiazepine-1-propanenitrile,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-2-oxo-
| 75696-02-5 |
1H-1,4-Benzodiazepine-7-sulfonamide,2,3-dihydro-N,N-dimethyl-2-oxo-5-phenyl-
| 33211-62-0 |
1H-1,4-Benzodiazepine-7-sulfonamide,2,3-dihydro-2-oxo-5-phenyl-
| 32224-64-9 |
1H-1,5-Benzodiazepine,2,3,4,5-tetrahydro-2,4-dimethyl-, cis-
| 58414-04-3 |
5H-Benzocyclohepten-6-amine,6,7,8,9-tetrahydro-N,6-dimethyl-, hydrochloride,(+-)-
| 56485-63-3 |
2H-1,4-Benzodiazepine-2-thione,7-chloro-1,3-dihydro-1-methyl-5-phenyl-
| 2898-13-7 |
2H-1,4-Benzodiazepine-2-thione,7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
| 36735-22-5 |
2H-1,5-Benzodiazepine-2-thione, 1,3-dihydro-4-phenyl-
| 41054-45-9 |
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-3-(2-hydroxyethyl)-
| 87744-52-3 |
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-3-(2-hydroxyethyl)-7-propoxy-
| 87744-99-8 |
2H-1,3-Benzodiazepine-2-thione,1,3,4,5-tetrahydro-7-methoxy-3-(2-methoxyethyl)-
| 87744-96-5 |
1H-1,5-Benzodiazepine-2-thione,2,3,4,5-tetrahydro-4-methyl-
| 74389-71-2 |
3H-2,4-Benzodiazepine-1,3,5(2H,4H)-trione, 7-nitro-
| 74389-71-2 |
3H-1,4-Benzodiazepin-3-ol,7-chloro-2-(dimethylamino)-5-phenyl-
| 76458-47-4 |
3H-1,4-Benzodiazepin-3-ol,7-chloro-2-(methylamino)-5-phenyl-
| 76458-47-4 |
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-, hydrochloride
| 62819-36-7 |
2H-1,4-Benzodiazepin-2-one,7-amino-1,3-dihydro-5-phenyl-
| 4928-02-3 |
2H-1,4-Benzodiazepin-2-one,7-bromo-5-(2-chlorophenyl)-1,3-dihydro-
| 51753-57-2 |
2H-1,4-Benzodiazepin-2-one,7-bromo-1,3-dihydro-5-(2-pyridyl)-
| 1812-30-2 |
2H-1,4-Benzodiazepin-2-one,7-bromo-1,3-dihydro-5-(2-pyridyl)-, nitrosated
| 104639-50-1 |
2H,1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
| 846-49-1 |
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-
| 14439-61-3 |
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(1-cyclohexen-1-yl)-1,3-dihydro-1-methyl-
| 10379-14-3 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-
| 25967-29-7 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, dihydrochloride
| 1172-18-5 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3- dihydro-, monohydrochloride
| 36105-20-1 |
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-5-(2-nitrophenoxy)-,monohydrochloride, cis-
| 72575-53-2 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hemisuccinyloxy-5-phenyl-,dimethylaminoethanol salt
| 16327-90-5 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-
| 846-50-4 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-
| 604-75-1 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-1-methyl-5-phenyl-
| 439-14-5 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-5-phenyl-
| 1088-11-5 |
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-5-phenyl-, 4-oxide
| 963-39-3 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-ethyl-
| 20378-80-7 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-methyl-
| 20430-79-9 |
3H-1,4-Benzodiazepin-2(1H)-one,8-chloro-5-ethoxy-1-methyl-
| 62903-63-3 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-ethoxy-1-phenyl-
| 20430-81-3 |
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-N,N-dimethyl-5-(4-nitrophenoxy)-,monohydrochloride, trans-
| 72575-49-6 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-5-(o-fluorophenoxy)-1-methyl-
| 62903-61-1 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-1-methyl-5-(2-propynyloxy)-
| 62903-59-7 |
3H-1,4-Benzodiazepin-2(1H)-one,7-chloro-1-methyl-5-(1-trifluoromethylethoxy)-
| 62903-57-5 |
2-H-1,4-Benzodiazepin-2-one,5-(o-chlorophenyl)-1,3-dihydro-7-nitro-
| 1622-61-3 |
2H-1,4-Benzodiazepin-2-one,7-chloro-5-phenyl-1,3,4,5-tetrahydro-
| 1824-69-7 |
1H-1,5-Benzodiazepin-2(3H)-one, 4,5-dihydro-5-acetyl-
| 1824-69-7 |
1H-1,5-Benzodiazepin-2(3H)-one,4,5-dihydro-1-acetyl-5-nitroso-
| 1824-69-7 |
1H-1,5-Benzodiazepin-2(3H)-one,4,5-dihydro-5-acetyl-1-propionyl-
| 1824-69-7 |
2H-1,5-Benzodiazepin-2-one,1,3-dihydro-4-amino-8-bromo-1-phenyl-
| 36985-34-9 |
2H-1,4-Benzodiazepin-2-one,1,3-dihydro-3-amino-7-chloro-5-phenyl-
| 894-77-9 |
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