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MSDS  : Acetic acid, ((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-
CAS  : 50892-23-4
SYNONYMS  : * Acetic acid, ((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)- * (4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio)acetic acid * Pirinixic acid * Pirnixic acid * WY-14,643 * Wyeth 14,643
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AG2915000
CHEMICAL NAME : Acetic acid,
((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-
CAS REGISTRY NUMBER : 50892-23-4
BEILSTEIN REFERENCE NO. : 0759945
REFERENCE : 5-25-12-00458 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C14-H14-Cl-N3-O2-S
MOLECULAR WEIGHT : 323.82
WISWESSER LINE NOTATION : T6N CNJ BS1VQ DG FMR B1 C1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Acetic acid,
((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-
* (4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio)acetic acid
* Pirinixic acid
* Pirnixic acid
* WY-14,643
* Wyeth 14,643

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 27,1621,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATHSBL Atherosclerosis (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland Ltd., POB 85, Limerick, Ireland) V.11- 1970-
Volume(issue)/page/year: 30,45,1978

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 330 mg/kg/8W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
145,425,1997

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 126 mg/kg/21D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - changes in prostate weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
19,590,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1092 mg/kg/26W-C
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
145,425,1997

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1545 mg/kg/2Y-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in platelet count
Related to Chronic Data - death
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 20,1,1997

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 22 gm/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
48,6739,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 37 gm/kg/62W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,152,1979

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 46 gm/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 2,645,1981

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27 gm/kg/64W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
32,33,1986

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 29 gm/kg/69W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,152,1979

** MUTATION DATA **

TYPE OF TEST : Micronucleus test
TEST SYSTEM : Human Liver
DOSE/DURATION : 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,123,1993

TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,123,1993

TYPE OF TEST : Morphological transformation
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 15540 mg/kg/37W (Continuous)
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 15,111,1994

TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1 mmol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
24,147,1984

TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 375 mg/kg/5D (Continuous)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,152,1979

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,123,1993

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 5 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,123,1993

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
40,36,1980

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 85 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,85,1996

*** STATUS IN U.S. ***

NTP Carcinogenesis studies; selected, October 1997

NTP Carcinogenesis studies; on test (prechronic studies), October 1997


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Acetic acid, (benzylthio)-, 2,3-dimercaptopropylester 90730-51-1
Acetic acid, ((4-chloro-o-tolyl)oxy)-,alpha-((dimethylamino)methyl)benzyl ester,hydrochloride 90730-51-1
Acetic acid, ((4-chloro-o-tolyl)oxy)-, ethyl ester 2698-38-6
Acetic acid, ((4-chloro-o-tolyl)oxy)-, compd. with2,2'-iminodiethanol (1:1) 20405-19-0
Acetic acid, ((4-chloro-o-tolyl)oxy)-, isooctyl ester 26544-20-7
Acetic acid, ((4-chloro-o-tolyl)oxy)-, methyl ester(8CI) 2436-73-9
Acetic acid, ((4-chloro-o-tolyl)oxy)-, potassium salt 5221-16-9
Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt 3653-48-3
Acetic acid, ((4-chloro-o-tolyl)oxy)thio-, S-ethylester 25319-90-8
Acetic acid, ((4-chloro-o-tolyl)sulfonyl)-, compd.with 2,2',2''-nitrilotrisethanol (1:1) 102582-95-6
Acetic acid, chloro-,2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester 74940-61-7
Acetic acid, (o-(benzylthio)phenyl)-,2-(dimethylamino)ethyl ester, hydrochloride 14200-07-8
Acetic acid, chloro-, 2,4,5-trichlorophenyl ester 5902-69-2
Acetic acid,(4-chloro-2-(alpha,alpha,alpha-trifluoro-m-toluamido)phenyl)- 17194-48-8
Acetic acid,(4-chloro-2-((alpha,alpha,alpha-trifluoro-m-tolyl)carbamoyl)phenoxy)- 35422-42-5
Acetic acid,((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)- 50892-23-4
Acetic acid, chromium(3+) salt 1066-30-4
Acetic acid, chromium(2+) salt, hydrate 628-52-4
Acetic acid, chromium(3+) salt, hydrate 25013-82-5
Acetic acid, cobalt(2+) salt 71-48-7
Acetic acid, cobalt(3+) salt 917-69-1
Acetic acid, cobalt(2+) salt, tetrahydrate 6147-53-1
Acetic acid, beryllium salt 543-81-7
Acetic acid, copper(2+) salt 142-71-2
Acetic acid, copper(2+) salt, monohydrate 6046-93-1
Acetic acid, cyano- 372-09-8
Acetic acid, cyano-, allyl ester 13361-32-5
Acetic acid, cyano-, benzylidenehydrazide 4974-44-1
Acetic acid, cyano-, butyl ester 5459-58-5
Acetic acid,cyano(1-(cyanomethyl)-2-pyrrolidinylidene)-, ethylester 106345-05-5
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-oxoethyl)-2-pyrrolidinylide ne)-, ethyl ester 126647-18-5
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-thioxoethyl)-2- pyrrolidinylidene)-, ethyl ester 111038-14-3
Acetic acid,alpha-cyano-alpha-(3,5-dimethyl-4-oxacyclohexylidene)-, ethyl ester 10292-81-6
Acetic acid, (4,4'-biphenylylenedithio)di-, compd.with 2,2',2''-nitrilotris(ethanol) (1:2) 87298-97-3
Acetic acid, (2-cyanoethoxy)diphenyl-,2-(dimethylamino)ethyl ester 94916-96-8
Acetic acid, cyano(ethoxyethylidene)-, ethyl ester 64046-50-0
Acetic acid, cyano-, ethyl ester 105-56-6
Acetic acid, cyano-, hexyl ester 13361-53-0
Acetic acid, cyano-, hydrazide 140-87-4
Acetic acid, cyano-, (o-hydroxybenzylidene)hydrazide 140-87-4
Acetic acid, cyano-,(4-hydroxy-3-methoxybenzylidene)hydrazide 140-87-4
Acetic acid, cyano-, isobutyl ester 13361-31-4
Acetic acid, cyano-, isopropyl ester 13361-30-3
Acetic acid, cyano-, 2-methoxyethyl ester 10258-54-5
Acetic acid, 2-(4-biphenylyl)-2-methyl-,2-piperidinoethyl ester 64046-66-8
Acetic acid,((2-cyano-3-(methylamino)phenyl)amino)oxo-,monosodium salt 63365-44-6
Acetic acid, cyano-, methyl ester 105-34-0
Acetic acid, cyano((3-methylphenyl)hydrazono)-, ethylester 3994-20-5
Acetic acid, cyano((4-methylphenyl)hydrazono)-, ethylester 6797-29-1
Acetic acid, cyano((3-methylphenyl)hydrazono)-,methyl ester 59061-89-1

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