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MSDS  : 1,3-Butanediol
CAS  : 107-88-0
SYNONYMS  : * 1,3-Butandiol * Butane-1,3-diol * beta-Butylene glycol * 1,3-Butylene glycol * 1,3-Butylenglykol * 1,3-Dihydroxybutane * Methyltrimethylene glycol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : EK0440000
CHEMICAL NAME : 1,3-Butanediol
CAS REGISTRY NUMBER : 107-88-0
BEILSTEIN REFERENCE NO. : 1731276
REFERENCE : 0-01-00-00477 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C4-H10-O2
MOLECULAR WEIGHT : 90.14
WISWESSER LINE NOTATION : QY1&2Q
COMPOUND DESCRIPTOR : Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,3-Butandiol
* Butane-1,3-diol
* beta-Butylene glycol
* 1,3-Butylene glycol
* 1,3-Butylenglykol
* 1,3-Dihydroxybutane
* Methyltrimethylene glycol

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,207,1986

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REACTION SEVERITY : Mild
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,207,1986

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18610 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,14,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12980 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,669,1956

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10276 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
49,385,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,14,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 11 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 42360 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 5(4),189,1986

*** REVIEWS ***

TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 4(5),223,1985

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83068
No. of Facilities: 1532 (estimated)
No. of Industries: 13
No. of Occupations: 22
No. of Employees: 36963 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83068
No. of Facilities: 1070 (estimated)
No. of Industries: 13
No. of Occupations: 17
No. of Employees: 19336 (estimated)
No. of Female Employees: 5266 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH Analytical Method, 1996: Glycols, 5523


*** END OF RECORD ***
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Butanedioic acid,mono(2-(dimethylamino)-1-((2-(2-(3-fluorophenyl)ethyl)phenoxy)methyl) ethyl) ester, hydrochloride 86819-21-8
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1,2-Butanediol 584-03-2
1,3-Butanediol 107-88-0
1,4-Butanediol 110-63-4
Biuret, 2,4-dithio-3-phenyl-1,1,5,5-tetramethyl- 33812-14-5
2,3-Butanediol 513-85-9
1,3-Butanediol,1-(p-anisyl)-2-methyl-4,4,4-trifluoro-3-(trifluoromethyl)- 34848-35-6
1,4-Butanediol, bis(1-aziridinepropionate) 25926-34-5
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2,3-Butanediol, 1,4-bis((2-mercaptoethyl)amino)-,dihydrochloride 18239-81-1
2,3-Butanediol,2,3-bis(trifluoromethyl)-1,1,1,4,4,4-hexafluoro- 918-21-8
1,2-Butanediol, 4-bromo-4,4-dinitro-1-phenyl- 63732-27-4
1,3-Butanediol,1-(p-bromophenyl)-2-methyl-3-trifluoromethyl-4,4,4-trifluoro- 34848-34-5
1,3-Butanediol, 4-(butylnitrosoamino)- 62018-91-1
1,3-Butanediol,4-chloro-3-chlorodifluoromethyl-4,4-difluoro-1-(2-furyl)- 34848-39-0
Biuret, 2,4-dithio-1-(p-propylphenyl)- 34848-39-0
1,3-Butanediol,4-chloro-3-(chlorodifluoromethyl)-4,4-difluoro-2-methyl-1-phenyl- 34848-27-6
1,3-Butanediol,4-chloro-3-chlorodifluoromethyl-4,4-difluoro-1-(2-thienyl)- 34848-40-3
1,3-Butanediol,1-(p-chlorophenyl)-2-ethyl-3-(trifluoromethyl)-4,4,4-trifluoro- 34848-31-2
2,3-Butanediol, 2-(m-chlorophenyl)-3-methyl- 13980-94-4
2,3-Butanediol, 2-(p-chlorophenyl)-3-methyl- 79-93-6

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