RTECS NUMBER : EJ9980000
CHEMICAL NAME : Butanedioic acid,
mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(
4,3-j)-1,2- benzodioxepin-10-yl)ester, sodium salt,
(3R-(3-alpha,5a-beta,6-beta,8a-beta,9-alpha,10-
alpha,12-beta,12aR*))-
CAS REGISTRY NUMBER : 82864-68-4
LAST UPDATED : 199503
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C19-H27-O8.Na
MOLECULAR WEIGHT : 406.45
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* SM 804
* Sodium artesunate
* Sodium dihydroarteannuin hydrogen succinate monoester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 438 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYTPDT Zhongyao Tongbao. Bulletin of Chinese Materia Medica. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3
Volume(issue)/page/year: 13,234,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
Medicine) V.1- 1981- Volume(issue)/page/year: 2,99,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 475 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
Medicine) V.1- 1981- Volume(issue)/page/year: 2,99,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 630 mg/kg/14D-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in other cell count (unspecified)
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological
Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986-
Volume(issue)/page/year: 1,135,1987
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 5400 ug/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
CYTPDT Zhongyao Tongbao. Bulletin of Chinese Materia Medica. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3
Volume(issue)/page/year: 13,234,1988
*** END OF RECORD ***
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