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MSDS  : Colchicine, N-deacetyl-10-thio-
CAS  : 2731-16-0
SYNONYMS  : * Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (S)- * Colchicine, N-deacetyl-10-demethoxy-10-methylthio- * Corps R. 261 * N-Deacetyl-10-demethoxy-10-methylthiocolchicine * N-Deacetylmethylthiocolchicine * N-Deacetylthiocolchicine * N-Desacetylthiocolchicine * R 261 * Thio-colciran
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GH0875000
CHEMICAL NAME : Colchicine, N-deacetyl-10-thio-
CAS REGISTRY NUMBER : 2731-16-0
BEILSTEIN REFERENCE NO. : 2822164
REFERENCE : 4-14-00-00954 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C20-H23-N-O4-S
MOLECULAR WEIGHT : 373.50
WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JZ NS1
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Benzo(a)heptalen-9(5H)-one,
7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (S)-
* Colchicine, N-deacetyl-10-demethoxy-10-methylthio-
* Corps R. 261
* N-Deacetyl-10-demethoxy-10-methylthiocolchicine
* N-Deacetylmethylthiocolchicine
* N-Deacetylthiocolchicine
* N-Desacetylthiocolchicine
* R 261
* Thio-colciran

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human
DOSE/DURATION : 71 ug/kg/D
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Blood - leukopenia
REFERENCE :
BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer. (Paris,
France) V.1-52, 1908-65. For publisher information, see BUCABS.
Volume(issue)/page/year: 42,308,1955

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 98,479,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 98,479,1958

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2000 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 15,533,1960

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer. (Paris,
France) V.1-52, 1908-65. For publisher information, see BUCABS.
Volume(issue)/page/year: 42,308,1955

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 66 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 107,150,1956

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE : 6 mg/kg
SEX/DURATION : female 13-14 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica,
Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948-
Volume(issue)/page/year: 166,435,1972

*** END OF RECORD ***
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NAMECAS
Colchicine,N-deacetyl-10-demethoxy-N-(2-deoxy-erythro-pentosyl)-10-(methylthio)- 63989-75-3
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Colchicine,N-deacetyl-10-demethoxy-N-glucopyranosyl-10-(methylthio)- 63989-75-3
Colchicine,N-deacetyl-10-demethoxy-N-lyxosyl-10-(methylthio)- 63989-75-3
Colchicine,N-deacetyl-10-demethoxy-10-(methylthio)-N-ribosyl- 63989-75-3
Colchicine,N-deacetyl-10-demethoxy-10-(methylthio)-N-xylosyl- 63989-75-3
Colchicine, N-deacetyl-N,N-dimethyl- 7336-44-9
Colchicine, N-deacetyl-N-formyl- 7411-12-3
Colchicine, N-deacetyl-N-formyl-N-methyl- 14686-61-4
Colchicine, N-deacetyl-N-formyl-10-thio- 2731-23-9
Colchicine, N-deacetyl-N-methyl- 477-30-5
Colchicine, N-deacetyl-N-(p-nitrobenzoyl)- 76129-13-0
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Colchicine, N-deacetyl-, d-tartrate 27963-65-1
Colchicine, N-deacetyl-10-thio- 2731-16-0
Colchicine, 10-demethoxy-10-(diethylamino)- 6962-03-4
Colchicine, 10-demethoxy-10-methylamino- 2826-80-4
Colchicine, 10-demethoxy-10-methylthio- 2730-71-4
Colchicine, O(sup 2)-demethyl- 7336-36-9
Colchicine, 3-O-demethyl- 7336-33-6
Colchicine, O(sup 1)-demethyl-, acetate 3306-60-3
Colchicine, O(sup 2)-demethyl-10-thio- 87424-26-8
Colchicine, 5,6-didehydrodeacetamido- 14511-67-2
Citric acid, triethyl ester, acetate 77-89-4
Clavamycin D 103059-95-6
Colchicine, 17-fluoro- 26195-68-6
Colchicine, N-methyl- 7336-40-5
Colchicine, N-methyl-17,17,17-trifluoro- 71295-35-7
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Colchicoside 477-29-2
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Colchinol, N-acetyl- 38838-26-5
Colchinol, N-acetyl-, methyl ether 65967-01-3
Clay (kaolin) 1332-58-7
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Colestipol, hydrochloride 37296-80-3
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Colisan 11051-89-1
Colistin 1066-17-7
Colistin A 7722-44-3
Colistinmethanesulfonic acid, sodium salt 8068-28-8
Collagen, pyrolyzate 8068-28-8
Clazamycin 90092-49-2
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