MSDS   | : | Colchicine, N-deacetyl-N,N-dimethyl-
| CAS   | : | 7336-44-9 | SYNONYMS   | : | * Benzo(a)heptalen-9(5H)-one,
7-dimethylamino-6,7-dihydro-1,2,3,10-tetramethoxy-, (S)-
* N-Deacetyl-N,N-dimethylcolchicine
* N-Methylcolchamine
* N-Methyldemecolcine
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GH0792000
CHEMICAL NAME : Colchicine, N-deacetyl-N,N-dimethyl-
CAS REGISTRY NUMBER : 7336-44-9
LAST UPDATED : 198706
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C22-H27-N-O5
MOLECULAR WEIGHT : 385.50
WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JN1&1 NO1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Benzo(a)heptalen-9(5H)-one,
7-dimethylamino-6,7-dihydro-1,2,3,10-tetramethoxy-, (S)-
* N-Deacetyl-N,N-dimethylcolchicine
* N-Methylcolchamine
* N-Methyldemecolcine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 24 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 45 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Colchicine,N-deacetyl-10-demethoxy-N-(2-deoxy-erythro-pentosyl)-10-(methylthio)-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-N-galactopyranosyl-10-(methylthio)-
| 63989-75-3 |
Clausena lansium (Lour.) Skeels, extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-N-glucopyranosyl-10-(methylthio)-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-N-lyxosyl-10-(methylthio)-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-10-(methylthio)-N-ribosyl-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-10-(methylthio)-N-xylosyl-
| 63989-75-3 |
Colchicine, N-deacetyl-N,N-dimethyl-
| 7336-44-9 |
Colchicine, N-deacetyl-N-formyl-
| 7411-12-3 |
Colchicine, N-deacetyl-N-formyl-N-methyl-
| 14686-61-4 |
Colchicine, N-deacetyl-N-formyl-10-thio-
| 2731-23-9 |
Colchicine, N-deacetyl-N-methyl-
| 477-30-5 |
Colchicine, N-deacetyl-N-(p-nitrobenzoyl)-
| 76129-13-0 |
Clausena pentaphylla (roxb.) DC., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 76129-13-0 |
Colchicine, N-deacetyl-, d-tartrate
| 27963-65-1 |
Colchicine, N-deacetyl-10-thio-
| 2731-16-0 |
Colchicine, 10-demethoxy-10-(diethylamino)-
| 6962-03-4 |
Colchicine, 10-demethoxy-10-methylamino-
| 2826-80-4 |
Colchicine, 10-demethoxy-10-methylthio-
| 2730-71-4 |
Colchicine, O(sup 2)-demethyl-
| 7336-36-9 |
Colchicine, 3-O-demethyl-
| 7336-33-6 |
Colchicine, O(sup 1)-demethyl-, acetate
| 3306-60-3 |
Colchicine, O(sup 2)-demethyl-10-thio-
| 87424-26-8 |
Colchicine, 5,6-didehydrodeacetamido-
| 14511-67-2 |
Citric acid, triethyl ester, acetate
| 77-89-4 |
Clavamycin D
| 103059-95-6 |
Colchicine, 17-fluoro-
| 26195-68-6 |
Colchicine, N-methyl-
| 7336-40-5 |
Colchicine, N-methyl-17,17,17-trifluoro-
| 71295-35-7 |
Colchicine, 17,17,17-trifluoro-
| 26195-65-3 |
Colchicinic acid, trimethyl-
| 3482-37-9 |
Colchicinic acid, trimethyl-methyl ether, d-tartrate,hydrate
| 49720-72-1 |
Colchicoside
| 477-29-2 |
Colchicum luteum Baker, corm extractSUBSTANCE DEFINITION :Plant belonging to the family LiliaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 477-29-2 |
Colchinol, N-acetyl-
| 38838-26-5 |
Colchinol, N-acetyl-, methyl ether
| 65967-01-3 |
Clay (kaolin)
| 1332-58-7 |
Colebrookea oppositifolia Sm., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family LamiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 1332-58-7 |
Colestipol, hydrochloride
| 37296-80-3 |
Coleus amboinicus Lour., extractSUBSTANCE DEFINITION :Plant belonging to the family LabiataeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 37296-80-3 |
Coleus caninus (roth) Vatke, extractSUBSTANCE DEFINITION :Plant belonging to the family LamiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 37296-80-3 |
Coleus forskohlii Brig., root extractSUBSTANCE DEFINITION :Plant belonging to the family LabiataeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 37296-80-3 |
Colisan
| 11051-89-1 |
Colistin
| 1066-17-7 |
Colistin A
| 7722-44-3 |
Colistinmethanesulfonic acid, sodium salt
| 8068-28-8 |
Collagen, pyrolyzate
| 8068-28-8 |
Clazamycin
| 90092-49-2 |
Colocasia affinis Schott, extractSUBSTANCE DEFINITION :Plant belonging to the family AraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 90092-49-2 |
Colocasia nymphaeifolia Kunth, leaf extractSUBSTANCE DEFINITION :Plant belonging to the family AraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 90092-49-2 |
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