MSDS   | : | Colchicinic acid, trimethyl-methyl ether, d-tartrate,
hydrate
| CAS   | : | 49720-72-1 | SYNONYMS   | : | * Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-,
(S)-, tartrate (1:1)
* Colchicine, deacetyl-, L-tartrate
* Colchicine, N-deacetyl-, L-tartrate (1:1), hydrate
* Colchicinic acid, O,O',O'',O'''-tetramethyl-, tartrate
* Desacetylcolchicine d-tartrate
* NCI 1136
* NSC-36354
* SKF 250
* TMCA methyl ester d-tartrate, hydrate
* Trimethylcolchicinic acid, methyl ether, L-tartrate
* Trimethylcolchicinic acid, methyl ether, d-tartrate, hydrate
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GH0980000
CHEMICAL NAME : Colchicinic acid, trimethyl-methyl ether, d-tartrate,
hydrate
CAS REGISTRY NUMBER : 49720-72-1
LAST UPDATED : 199610
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C20-H23-N-O5.C4-H6-O6.H2-O
MOLECULAR WEIGHT : 525.56
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-,
(S)-, tartrate (1:1)
* Colchicine, deacetyl-, L-tartrate
* Colchicine, N-deacetyl-, L-tartrate (1:1), hydrate
* Colchicinic acid, O,O',O'',O'''-tetramethyl-, tartrate
* Desacetylcolchicine d-tartrate
* NCI 1136
* NSC-36354
* SKF 250
* TMCA methyl ester d-tartrate, hydrate
* Trimethylcolchicinic acid, methyl ether, L-tartrate
* Trimethylcolchicinic acid, methyl ether, d-tartrate, hydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 200 ug/kg/7D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Blood - leukopenia
Blood - thrombocytopenia
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59,
1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
56,263,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year:
9,1,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 70520 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year:
9,1,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 9500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year:
9,1,1973
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Colchicine,N-deacetyl-10-demethoxy-N-(2-deoxy-erythro-pentosyl)-10-(methylthio)-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-N-galactopyranosyl-10-(methylthio)-
| 63989-75-3 |
Clausena lansium (Lour.) Skeels, extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-N-glucopyranosyl-10-(methylthio)-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-N-lyxosyl-10-(methylthio)-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-10-(methylthio)-N-ribosyl-
| 63989-75-3 |
Colchicine,N-deacetyl-10-demethoxy-10-(methylthio)-N-xylosyl-
| 63989-75-3 |
Colchicine, N-deacetyl-N,N-dimethyl-
| 7336-44-9 |
Colchicine, N-deacetyl-N-formyl-
| 7411-12-3 |
Colchicine, N-deacetyl-N-formyl-N-methyl-
| 14686-61-4 |
Colchicine, N-deacetyl-N-formyl-10-thio-
| 2731-23-9 |
Colchicine, N-deacetyl-N-methyl-
| 477-30-5 |
Colchicine, N-deacetyl-N-(p-nitrobenzoyl)-
| 76129-13-0 |
Clausena pentaphylla (roxb.) DC., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 76129-13-0 |
Colchicine, N-deacetyl-, d-tartrate
| 27963-65-1 |
Colchicine, N-deacetyl-10-thio-
| 2731-16-0 |
Colchicine, 10-demethoxy-10-(diethylamino)-
| 6962-03-4 |
Colchicine, 10-demethoxy-10-methylamino-
| 2826-80-4 |
Colchicine, 10-demethoxy-10-methylthio-
| 2730-71-4 |
Colchicine, O(sup 2)-demethyl-
| 7336-36-9 |
Colchicine, 3-O-demethyl-
| 7336-33-6 |
Colchicine, O(sup 1)-demethyl-, acetate
| 3306-60-3 |
Colchicine, O(sup 2)-demethyl-10-thio-
| 87424-26-8 |
Colchicine, 5,6-didehydrodeacetamido-
| 14511-67-2 |
Citric acid, triethyl ester, acetate
| 77-89-4 |
Clavamycin D
| 103059-95-6 |
Colchicine, 17-fluoro-
| 26195-68-6 |
Colchicine, N-methyl-
| 7336-40-5 |
Colchicine, N-methyl-17,17,17-trifluoro-
| 71295-35-7 |
Colchicine, 17,17,17-trifluoro-
| 26195-65-3 |
Colchicinic acid, trimethyl-
| 3482-37-9 |
Colchicinic acid, trimethyl-methyl ether, d-tartrate,hydrate
| 49720-72-1 |
Colchicoside
| 477-29-2 |
Colchicum luteum Baker, corm extractSUBSTANCE DEFINITION :Plant belonging to the family LiliaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 477-29-2 |
Colchinol, N-acetyl-
| 38838-26-5 |
Colchinol, N-acetyl-, methyl ether
| 65967-01-3 |
Clay (kaolin)
| 1332-58-7 |
Colebrookea oppositifolia Sm., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family LamiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 1332-58-7 |
Colestipol, hydrochloride
| 37296-80-3 |
Coleus amboinicus Lour., extractSUBSTANCE DEFINITION :Plant belonging to the family LabiataeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 37296-80-3 |
Coleus caninus (roth) Vatke, extractSUBSTANCE DEFINITION :Plant belonging to the family LamiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 37296-80-3 |
Coleus forskohlii Brig., root extractSUBSTANCE DEFINITION :Plant belonging to the family LabiataeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 37296-80-3 |
Colisan
| 11051-89-1 |
Colistin
| 1066-17-7 |
Colistin A
| 7722-44-3 |
Colistinmethanesulfonic acid, sodium salt
| 8068-28-8 |
Collagen, pyrolyzate
| 8068-28-8 |
Clazamycin
| 90092-49-2 |
Colocasia affinis Schott, extractSUBSTANCE DEFINITION :Plant belonging to the family AraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 90092-49-2 |
Colocasia nymphaeifolia Kunth, leaf extractSUBSTANCE DEFINITION :Plant belonging to the family AraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 90092-49-2 |
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