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MSDS  : Colchicine, 10-amino-10-demethoxy-
CAS  : 3123-89-5
SYNONYMS  : * Acetamide, N-(10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7- yl)-, (S)- * 14-Aminocolchicide * Colchicamid * Colchicamide * Colchiceeinamide * Colchiceinamid * Colchiceinamide * Colchicine amide
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GH0710000
CHEMICAL NAME : Colchicine, 10-amino-10-demethoxy-
CAS REGISTRY NUMBER : 3123-89-5
BEILSTEIN REFERENCE NO. : 2824077
REFERENCE : 4-14-00-00921 (Beilstein Handbook Reference)
LAST UPDATED : 199703
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C21-H24-N2-O5
MOLECULAR WEIGHT : 384.47
WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMV1 NZ
SYNONYMS/TRADE NAMES :
* Acetamide,
N-(10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-
yl)-, (S)-
* 14-Aminocolchicide
* Colchicamid
* Colchicamide
* Colchiceeinamide
* Colchiceinamid
* Colchiceinamide
* Colchicine amide

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 29600 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 33500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 98,236,1954

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 43 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 8900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 85,235,1920

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 160 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 85,235,1920

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 12 mg/kg/24D-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion
Gastrointestinal - nausea or vomiting
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
CMJODS Chinese Medical Journal (Beijing, English Edition). (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year:
93,188,1980

*** END OF RECORD ***
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