MSDS   | : | Colchiceine
| CAS   | : | 477-27-0 | SYNONYMS   | : | * 7-Acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo(a)heptalen-9(5H
)-one
* N-Acetyl trimethylcolchicinic acid
* Benzo(a)heptalen-9(5H)-one,
7-acetamido-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-
* Benzo(a)heptalen-10(5H)-one,
7-acetamido-6,7-dihydro-9-hydroxy-1,2,3-trimethoxy-
* O(sup 10)-Demethylcolchicine
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GH0520000
CHEMICAL NAME : Colchiceine
CAS REGISTRY NUMBER : 477-27-0
BEILSTEIN REFERENCE NO. : 2824078
REFERENCE : 4-14-00-00943 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C21-H23-N-O6
MOLECULAR WEIGHT : 385.45
WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMV1 NQ
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Human
Natural Product
SYNONYMS/TRADE NAMES :
* 7-Acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo(a)heptalen-9(5H
)-one
* N-Acetyl trimethylcolchicinic acid
* Benzo(a)heptalen-9(5H)-one,
7-acetamido-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-
* Benzo(a)heptalen-10(5H)-one,
7-acetamido-6,7-dihydro-9-hydroxy-1,2,3-trimethoxy-
* O(sup 10)-Demethylcolchicine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 43 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,250,1966
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach,
CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year:
33,1606,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2500 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 3,124,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 84 mg/kg
TOXIC EFFECTS :
Blood - hemorrhage
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 3,124,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
Volume(issue)/page/year: 241,1889,1955
** MUTATION DATA **
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 42 mg/kg
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 3,130,1950
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 84 mg/kg
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 3,134,1950
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 84 mg/kg
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 3,134,1950
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 250 nmol/L
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
Volume(issue)/page/year: 137,779,1990
*** END OF RECORD ***
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