MSDS   | : | Colchicine, N-deacetyl-N-benzoyl-
| CAS   | : | 63989-75-3 | SYNONYMS   | : | * Benzamide,
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,
(S)-
* N-Benzoyl tmca methyl ether
* N-Benzoyl trimethyl colchicinic acid methyl ether
* N-Benzoyltrimethylcolchicinsaeuremethylaether
* Colchicine, N-benzoyl-N-deacetyl-
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GH0790000
CHEMICAL NAME : Colchicine, N-deacetyl-N-benzoyl-
CAS REGISTRY NUMBER : 63989-75-3
BEILSTEIN REFERENCE NO. : 3184511
REFERENCE : 4-14-00-00952 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C27-H27-N-O6
MOLECULAR WEIGHT : 461.55
WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMVR& NO1
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Benzamide,
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,
(S)-
* N-Benzoyl tmca methyl ether
* N-Benzoyl trimethyl colchicinic acid methyl ether
* N-Benzoyltrimethylcolchicinsaeuremethylaether
* Colchicine, N-benzoyl-N-deacetyl-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 27 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 27924 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 12500 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Gastrointestinal - other changes
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 72,228,1913
** MUTATION DATA **
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 8 mg/kg
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 3,130,1950
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 32 mg/kg
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 3,134,1950
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 32 mg/kg
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 3,134,1950
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Cochineal (dye)
| 1343-78-8 |
Cochlioquinone A, (8-alpha)-
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Coclaurine, O-demethyl-, (+-)-
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Cocoa fatty acids, potassium salts
| 61789-30-8 |
Coconut dimethyl amine oxide
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Coconut oil acid diethanolamine
| 68603-42-9 |
Coconut oil, sodium N-methyltauride salt
| 104639-43-2 |
Cocos nucifera Linn. (Dab), extractSUBSTANCE DEFINITION :Plant belonging to the family PalmaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 104639-43-2 |
Clausena anisata Hook. f., extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
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Codeine-B, diacetyldihydrohydroxy-
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Codeine B, dihydro-14-hydroxy-
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Codeine-C, diacetyldihydrohydroxy-
| 7183-69-9 |
Codeinone, dihydro-, hydrochloride, hydrate
| 5965-14-0 |
Codeinone, 14-hydroxy-
| 508-54-3 |
Codiaeum variegatum Blume, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family EuphorbiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 508-54-3 |
Codiaeum variegatum Muell. var. pictum ev. Mr.Peters, leaf extract
| 508-54-3 |
Codiocarpus andamanicus (Kurz) Howard, extractSUBSTANCE DEFINITION :Plant belonging to the family IcarinaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,691,1990
| 508-54-3 |
Codonopsis pilosula (franch.) nannf., extract
| 508-54-3 |
Codonopsis pilosula (Franch.) Nannf., polysaccharide
| 508-54-3 |
Clausena heptaphylla Wt. & Arn., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 508-54-3 |
Coed crude
| 508-54-3 |
Coelicolorin
| 1403-39-0 |
Coelogyne corymbros Lindl., extractSUBSTANCE DEFINITION :Indian plant belonging to the family OrchidaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 1403-39-0 |
Coelogyne cristata Lindl., extractSUBSTANCE DEFINITION :Plant belonging to the family OrchidaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 1403-39-0 |
Coelogyne ochracea Lindl., extractSUBSTANCE DEFINITION :Plant belonging to the family OrchidaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 1403-39-0 |
Coelogyne schultesii Jain & Das, extractSUBSTANCE DEFINITION :Plant belonging to the family OrchidaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 1403-39-0 |
Coelogyne strict (D.Don)Schult., extractSUBSTANCE DEFINITION :Indian plant belonging to the family OrchidaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 1403-39-0 |
Coerulomycin
| 100927-17-1 |
Coffea arabica Linn., extract excluding roots
| 84650-00-0 |
Coffea bengalensis Roxb., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RubiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 9,91,1971
| 84650-00-0 |
Clausena indica (Dalz.)-Oliver, extractSUBSTANCE DEFINITION :Plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 84650-00-0 |
Coffee
| 84650-00-0 |
Coffee extract
| 8001-67-0 |
Coke oven emissions
| 8001-67-0 |
Colanic acid
| 9012-87-7 |
Cola nitida Schott et Endl., extractSUBSTANCE DEFINITION :Plant belonging to the family SterculiaceaeREFERENCE :CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,1255 Howard St., San Francisco, CA 94103) V.6- 1958-Volume(issue)/page/year: 13,882,1965
| 9012-87-7 |
Cola nitida, nut extract
| 9012-87-7 |
Colchiceine
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Colchiceine, N-deacetyl-N-benzoyl-
| 14686-58-9 |
Colchiceine, N-deacetyl-N-methyl-
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Colchicine
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Colchicine, (+)-
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Colchicine, N-(p-aminobenzenesulfonyl)-N-deacetyl-
| 75520-89-7 |
Colchicine, 10-amino-10-demethoxy-
| 3123-89-5 |
Colchicine, 10-amino-10-demethoxy-, tartrate
| 3123-89-5 |
Colchicine,N-arabinosyl-N-deacetyl-10-demethoxy-10-(methylthio)-
| 3123-89-5 |
Colchicine, 17-chloro-
| 26279-89-0 |
Colchicine, N-deacetyl-
| 3476-50-4 |
Colchicine, N-deacetyl-N-benzoyl-
| 63989-75-3 |
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