Search   
MSDS  : 18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-
CAS  : 16320-04-0
SYNONYMS  : * 18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha)- * 13-Ethyl-17-alpha-ethinyl-17-hydroxygon-4,9,11-trien-3-one * 13-beta-Ethyl-17-alpha-ethinyl-17-hydroxy-gona-4,9,11-triene-3-one * 13-Ethyl-17-hydroxy-18,19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one * Ethylnorgestrienone * Gestrigone * Gestrinone * R-2323 * RU 2323
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : JF7964000
CHEMICAL NAME : 18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,
13-ethyl-17-hydroxy-
CAS REGISTRY NUMBER : 16320-04-0
OTHER CAS REGISTRY NOS. : 40542-65-2
BEILSTEIN REFERENCE NO. : 5610726
LAST UPDATED : 199612
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C21-H24-O2
MOLECULAR WEIGHT : 308.45
COMPOUND DESCRIPTOR : Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* 18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-,
(17-alpha)-
* 13-Ethyl-17-alpha-ethinyl-17-hydroxygon-4,9,11-trien-3-one
* 13-beta-Ethyl-17-alpha-ethinyl-17-hydroxy-gona-4,9,11-triene-3-one
* 13-Ethyl-17-hydroxy-18,19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one
* Ethylnorgestrienone
* Gestrigone
* Gestrinone
* R-2323
* RU 2323

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,701,1988

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
Behavioral - altered sleep time (including change in righting reflex)
Nutritional and Gross Metabolic - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,701,1988

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,701,1988

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 400 ug/kg
SEX/DURATION : female 8 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 14,275,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 1200 ug/kg
SEX/DURATION : female 12 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 31,278,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Human - woman
DOSE : 1800 ug/kg
SEX/DURATION : female 48 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 11,625,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravaginal
SPECIES OBSERVED : Human - woman
DOSE : 185 ug/kg
SEX/DURATION : female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 14,671,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravaginal
SPECIES OBSERVED : Human - woman
DOSE : 2600 ug/kg
SEX/DURATION : female 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 49,418,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 50 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,713,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 500 ug/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,713,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 20 mg/kg
SEX/DURATION : female 15-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,737,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1200 mg/kg
SEX/DURATION : female 15-18 day(s) after conception
lactating female 20 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,737,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Primate - monkey
DOSE : 2486 ug/kg
SEX/DURATION : female 1 year(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 15,335,1977

*** END OF RECORD ***
Search More   
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Digitalis lanata, extract 65323-80-0
18,19-Dinorpregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-, oxime, (17-alpha)- 82332-21-6
18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy- 16320-04-0
18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-, and testosterone 16320-04-0
A,19-Dinor-17-alpha-pregn-20-ene-2-beta,17-diol,2-ethynyl-20,21,21-trifluoro- 16320-04-0
18,19-Dinorpregn-4-ene-3,20-dione 2299-98-1
18,19-Dinor-17-alpha-pregn-4-en-3-one,13-ethyl-17-hydroxy- 797-58-0
18,19-Dinor-17-alpha-pregn-4-en-3-one,13-ethyl-17-hydroxy-, (+-)- 1235-15-0
18,19-Dinorpregn-4-en-20-yn-17-ol,13-ethyl-11-methylene-, (17-alpha)- 54024-22-5
18,19-Dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)- 35189-28-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,21-chloro-13-ethyl-17-hydroxy-, (+-)- 2415-28-3
Digitalis lanata standard 90028-00-5
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,21-chloro-13-ethyl-17-hydroxy-, mixed with3-methoxy-17-alpha-19-norpregna-1,3,5(10)trien-20-yn-17-ol 90028-00-5
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+)- 797-63-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+-)- 6533-00-2
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(8-alpha,9-beta,10-alpha,13-alpha, 14-beta)- 797-64-8
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy- mixed with 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol 797-64-8
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- 54048-10-1
18,19-Dinorpregn-4-en-20-yn-3-one,12-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (5:3) 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (15:8) 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (25:6) 39366-37-5
Digitalis lutea, leaf extract 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-(+-)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol 8056-51-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+-)-, and19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol 8056-51-7
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, oxime,(8-alpha,9-beta,10-alpha,13- alpha,14-beta)- 53016-31-2
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,17-hydroxy-13-propyl- 1044-96-8
A,19-Dinor-17-alpha-pregn-20-yne-2-beta,17-diol,2-ethynyl- 1044-96-8
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,(2-alpha,5-alpha,17-alpha)- 64675-09-8
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,diacetate, (2-beta,5-alpha,17-alpha)- 70226-89-0
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,dipropanoate, (2-alpha,5-alpha,17-alpha)- 64675-10-1
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,dipropanoate, (2-beta,5-alpha,17-alpha)- 64675-08-7
18,24-Dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic acid, 6-(acetyloxy)-7,15:21,23-diepoxy-4,8-dimethyl-1-oxo-, dimethylester, sodium salt,(4-alpha,5-alpha,6-alpha,7-alpha,15-beta,17-alpha)- 64675-08-7
Digitalis orientalis, leaf extract 64675-08-7
Diocytlamine, N-nitroso- 6335-97-3
Diodia sarmentosa Swartz, extractSUBSTANCE DEFINITION :Plant belonging to the family RubiaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year:42,179,1994 6335-97-3
Dioscine 469-88-5
Dioscorea alata Linn., rhizome extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea belophylla Voight, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984 469-88-5
Dioscoria bulbifera Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoriaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea bulbifera Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea dumetorum, alkaloidsSUBSTANCE DEFINITION :Extracted and purified from a species of the yam family, common in the wildstate, in NigeriaREFERENCE :NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)V.1- 1869- Volume(issue)/page/year: 177,935,1956 469-88-5
Dioscorea dumetorum (knuth) Pax., tuber extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979- 469-88-5
Dioscorea glabra Roxb., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984 469-88-5
Digitalis purpurea, extract 469-88-5
Dioscorea nipponica Mak., extract 469-88-5
Dioscorea oppositifolia Linn., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977 469-88-5
Dioscorea pentaphylla Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980 469-88-5
Dioscorea puber Bl., fruit and plant extractexcluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974 469-88-5
Dioscorea sativa L., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990 469-88-5

Free MSDS Search ( Providing 250,000+ Material Properties )
Chemcas.com| Ads link:todaystock.net