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MSDS  : 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha)-(+-)-, mixt. with (17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-d iol
CAS  : 8056-51-7
SYNONYMS  : * Biphasil * Duoluton * Ediwal * Ethinyl estradiol mixed with norgestrel * Ethinylestradiol mixed with dl-norgestrel * Ethinyloestradiol mixed with norgestrel * Eugynon * Eugynon 30 * Femenal * Follimin * Follinett * Follinyl * Gravistat * Lo-Femenal * LO/Ovral * Microgynon * Microvlar 30 * Minidril * Neogynon * Neovletta * Nordiol * Nordiol-28 * Norgestrel-ethynylestradiol mixt. * Norgestrel mixed with ethinyl estradiol * dl-Norgestrel mixed with ethinylestradiol * Norgestrel mixed with ethinyloestradiol * Orasecron * Ovidon * Ovral * Ovral 21 * Ovral 28 * Ovral L * Ovran * Ovranett * Primovlar * Pro-Duosterone * Rigevidon * Sequilar * Sequilarum * Sequostat * SH 71121 * SHB 261AB * SHB 264AB * Stediril * Stediril D * Triquilar * WL 20 * WL 33 * WY-E 104
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : JF8300000
CHEMICAL NAME : 18,19-Dinorpregn-4-en-20-yn-3-one,
13-ethyl-17-hydroxy-, (17-alpha)-(+-)-, mixt. with
(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-d
iol
CAS REGISTRY NUMBER : 8056-51-7
OTHER CAS REGISTRY NOS. : 70208-30-9
8064-50-4
8063-84-1
LAST UPDATED : 199712
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C21-H28-O2.C20-H24-O2
MOLECULAR WEIGHT : 608.93
COMPOUND DESCRIPTOR : Tumorigen
Drug
Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* Biphasil
* Duoluton
* Ediwal
* Ethinyl estradiol mixed with norgestrel
* Ethinylestradiol mixed with dl-norgestrel
* Ethinyloestradiol mixed with norgestrel
* Eugynon
* Eugynon 30
* Femenal
* Follimin
* Follinett
* Follinyl
* Gravistat
* Lo-Femenal
* LO/Ovral
* Microgynon
* Microvlar 30
* Minidril
* Neogynon
* Neovletta
* Nordiol
* Nordiol-28
* Norgestrel-ethynylestradiol mixt.
* Norgestrel mixed with ethinyl estradiol
* dl-Norgestrel mixed with ethinylestradiol
* Norgestrel mixed with ethinyloestradiol
* Orasecron
* Ovidon
* Ovral
* Ovral 21
* Ovral 28
* Ovral L
* Ovran
* Ovranett
* Primovlar
* Pro-Duosterone
* Rigevidon
* Sequilar
* Sequilarum
* Sequostat
* SH 71121
* SHB 261AB
* SHB 264AB
* Stediril
* Stediril D
* Triquilar
* WL 20
* WL 33
* WY-E 104

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,567,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,567,1982

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 18144 ug/kg/12Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,273,1980

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 5 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 2,926,1973

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 756 ug/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
Volume(issue)/page/year: 2,223,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 50 mg/kg/5Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
235,730,1976

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 308 ug/kg
SEX/DURATION : lactating female 28 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 62,964,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 220 ug/kg
SEX/DURATION : female 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 26,23,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 3 mg/kg
SEX/DURATION : female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 108,183,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 1966 ug/kg
SEX/DURATION : female 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 10,127,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 44 ug/kg
SEX/DURATION : female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 37,508,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 44 ug/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 32,297,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1050 ug/kg
SEX/DURATION : female 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New
Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year:
11,389,1966

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 8750 ug/kg
SEX/DURATION : female 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New
Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year:
11,389,1966

*** REVIEWS ***

TOXICOLOGY REVIEW
CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a
High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year:
4,309,1976

TOXICOLOGY REVIEW
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 21,225,1980


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Digitalis lanata, extract 65323-80-0
18,19-Dinorpregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-, oxime, (17-alpha)- 82332-21-6
18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy- 16320-04-0
18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-, and testosterone 16320-04-0
A,19-Dinor-17-alpha-pregn-20-ene-2-beta,17-diol,2-ethynyl-20,21,21-trifluoro- 16320-04-0
18,19-Dinorpregn-4-ene-3,20-dione 2299-98-1
18,19-Dinor-17-alpha-pregn-4-en-3-one,13-ethyl-17-hydroxy- 797-58-0
18,19-Dinor-17-alpha-pregn-4-en-3-one,13-ethyl-17-hydroxy-, (+-)- 1235-15-0
18,19-Dinorpregn-4-en-20-yn-17-ol,13-ethyl-11-methylene-, (17-alpha)- 54024-22-5
18,19-Dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)- 35189-28-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,21-chloro-13-ethyl-17-hydroxy-, (+-)- 2415-28-3
Digitalis lanata standard 90028-00-5
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,21-chloro-13-ethyl-17-hydroxy-, mixed with3-methoxy-17-alpha-19-norpregna-1,3,5(10)trien-20-yn-17-ol 90028-00-5
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+)- 797-63-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+-)- 6533-00-2
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(8-alpha,9-beta,10-alpha,13-alpha, 14-beta)- 797-64-8
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy- mixed with 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol 797-64-8
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- 54048-10-1
18,19-Dinorpregn-4-en-20-yn-3-one,12-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (5:3) 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (15:8) 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (25:6) 39366-37-5
Digitalis lutea, leaf extract 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-(+-)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol 8056-51-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+-)-, and19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol 8056-51-7
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, oxime,(8-alpha,9-beta,10-alpha,13- alpha,14-beta)- 53016-31-2
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,17-hydroxy-13-propyl- 1044-96-8
A,19-Dinor-17-alpha-pregn-20-yne-2-beta,17-diol,2-ethynyl- 1044-96-8
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,(2-alpha,5-alpha,17-alpha)- 64675-09-8
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,diacetate, (2-beta,5-alpha,17-alpha)- 70226-89-0
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,dipropanoate, (2-alpha,5-alpha,17-alpha)- 64675-10-1
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,dipropanoate, (2-beta,5-alpha,17-alpha)- 64675-08-7
18,24-Dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic acid, 6-(acetyloxy)-7,15:21,23-diepoxy-4,8-dimethyl-1-oxo-, dimethylester, sodium salt,(4-alpha,5-alpha,6-alpha,7-alpha,15-beta,17-alpha)- 64675-08-7
Digitalis orientalis, leaf extract 64675-08-7
Diocytlamine, N-nitroso- 6335-97-3
Diodia sarmentosa Swartz, extractSUBSTANCE DEFINITION :Plant belonging to the family RubiaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year:42,179,1994 6335-97-3
Dioscine 469-88-5
Dioscorea alata Linn., rhizome extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea belophylla Voight, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984 469-88-5
Dioscoria bulbifera Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoriaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea bulbifera Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea dumetorum, alkaloidsSUBSTANCE DEFINITION :Extracted and purified from a species of the yam family, common in the wildstate, in NigeriaREFERENCE :NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)V.1- 1869- Volume(issue)/page/year: 177,935,1956 469-88-5
Dioscorea dumetorum (knuth) Pax., tuber extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979- 469-88-5
Dioscorea glabra Roxb., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984 469-88-5
Digitalis purpurea, extract 469-88-5
Dioscorea nipponica Mak., extract 469-88-5
Dioscorea oppositifolia Linn., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977 469-88-5
Dioscorea pentaphylla Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980 469-88-5
Dioscorea puber Bl., fruit and plant extractexcluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974 469-88-5
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