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MSDS  : 18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (+)-
CAS  : 797-63-7
SYNONYMS  : * 17-alpha-Ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one * 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one * 13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one * 17-Ethynyl-18-methyl-19-nortestosterone * 17-beta-Hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one * 18-Methyl-17-alpha-ethynyl-19-nortestosterone * d-Norgestrel * d(-)-Norgestrel * D-Norgestrel * Postinor
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : JF8225000
CHEMICAL NAME : 18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,
13-ethyl-17-hydroxy-, (+)-
CAS REGISTRY NUMBER : 797-63-7
BEILSTEIN REFERENCE NO. : 2391114
LAST UPDATED : 199612
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C21-H28-O2
MOLECULAR WEIGHT : 312.49
WISWESSER LINE NOTATION : L E5 B666 OV MUTJ E2 FQ F1UU1 -D
COMPOUND DESCRIPTOR : Tumorigen
Drug
Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* 17-alpha-Ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one
* 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one
* 13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one
* 17-Ethynyl-18-methyl-19-nortestosterone
* 17-beta-Hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one
* 18-Methyl-17-alpha-ethynyl-19-nortestosterone
* d-Norgestrel
* d(-)-Norgestrel
* D-Norgestrel
* Postinor

*** HEALTH HAZARD DATA ***

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1820 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year:
34,319,1979

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 29 mg/kg/69W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 168,1190,1974

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 274 ug/kg
SEX/DURATION : female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 24,191,1973

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 20 ug/kg
SEX/DURATION : female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New
Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year:
20,156,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 109 ug/kg
SEX/DURATION : female 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New
Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year:
17,17,1972

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 5 ug/kg
SEX/DURATION : female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 7,367,1973

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 8 ug/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 11,31,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Human - woman
DOSE : 38160 ng/kg
SEX/DURATION : female 22 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 18,411,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Human - woman
DOSE : 1600 ug/kg
SEX/DURATION : female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 12,615,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 10 ug/kg
SEX/DURATION : female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 11,321,1973

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 960 mg/kg
SEX/DURATION : female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 16,541,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 10 ug/kg
SEX/DURATION : female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 17,684,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 120 ug/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 35,459,1985

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE : 1600 ug/kg
SEX/DURATION : female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 12,529,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE : 1800 ug/kg
SEX/DURATION : female 43 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 16,499,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 4500 ug/kg
SEX/DURATION : female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 21,61,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 1875 ug/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 30,153,1984

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 300 ug/kg
SEX/DURATION : female 2 day(s) pre-mating
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 117,167,1973

*** REVIEWS ***

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 21,479,1979

IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 21,479,1979

TOXICOLOGY REVIEW
CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a
High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year:
4,309,1976


*** END OF RECORD ***
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NAMECAS
Digitalis lanata, extract 65323-80-0
18,19-Dinorpregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-, oxime, (17-alpha)- 82332-21-6
18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy- 16320-04-0
18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-, and testosterone 16320-04-0
A,19-Dinor-17-alpha-pregn-20-ene-2-beta,17-diol,2-ethynyl-20,21,21-trifluoro- 16320-04-0
18,19-Dinorpregn-4-ene-3,20-dione 2299-98-1
18,19-Dinor-17-alpha-pregn-4-en-3-one,13-ethyl-17-hydroxy- 797-58-0
18,19-Dinor-17-alpha-pregn-4-en-3-one,13-ethyl-17-hydroxy-, (+-)- 1235-15-0
18,19-Dinorpregn-4-en-20-yn-17-ol,13-ethyl-11-methylene-, (17-alpha)- 54024-22-5
18,19-Dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)- 35189-28-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,21-chloro-13-ethyl-17-hydroxy-, (+-)- 2415-28-3
Digitalis lanata standard 90028-00-5
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,21-chloro-13-ethyl-17-hydroxy-, mixed with3-methoxy-17-alpha-19-norpregna-1,3,5(10)trien-20-yn-17-ol 90028-00-5
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+)- 797-63-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+-)- 6533-00-2
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(8-alpha,9-beta,10-alpha,13-alpha, 14-beta)- 797-64-8
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy- mixed with 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol 797-64-8
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18,19-Dinorpregn-4-en-20-yn-3-one,12-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol 39366-37-5
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18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (25:6) 39366-37-5
Digitalis lutea, leaf extract 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-(+-)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol 8056-51-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+-)-, and19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol 8056-51-7
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, oxime,(8-alpha,9-beta,10-alpha,13- alpha,14-beta)- 53016-31-2
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,17-hydroxy-13-propyl- 1044-96-8
A,19-Dinor-17-alpha-pregn-20-yne-2-beta,17-diol,2-ethynyl- 1044-96-8
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,(2-alpha,5-alpha,17-alpha)- 64675-09-8
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,diacetate, (2-beta,5-alpha,17-alpha)- 70226-89-0
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,dipropanoate, (2-alpha,5-alpha,17-alpha)- 64675-10-1
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,dipropanoate, (2-beta,5-alpha,17-alpha)- 64675-08-7
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Dioscine 469-88-5
Dioscorea alata Linn., rhizome extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea belophylla Voight, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984 469-88-5
Dioscoria bulbifera Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoriaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea bulbifera Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea dumetorum, alkaloidsSUBSTANCE DEFINITION :Extracted and purified from a species of the yam family, common in the wildstate, in NigeriaREFERENCE :NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)V.1- 1869- Volume(issue)/page/year: 177,935,1956 469-88-5
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Digitalis purpurea, extract 469-88-5
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Dioscorea pentaphylla Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980 469-88-5
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