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MSDS  : 18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one, 21-chloro-13-ethyl-17-hydroxy-, mixed with 3-methoxy-17-alpha-19-norpregna-1,3,5(10)trien-20-yn- 17-ol
CAS  : 90028-00-5
SYNONYMS  : * Chloroethynyl norgestrel mixed with mestranol (20:1) * Mestranol mixed with chloroethynyl norgestrel (1:20) * Wy-4355 mixed with Mestranol (20:1)
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : JF7980000
CHEMICAL NAME : 18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,
21-chloro-13-ethyl-17-hydroxy-, mixed with
3-methoxy-17-alpha-19-norpregna-1,3,5(10)trien-20-yn-
17-ol
LAST UPDATED : 198910
DATA ITEMS CITED : 3
COMPOUND DESCRIPTOR : Tumorigen
Drug
SYNONYMS/TRADE NAMES :
* Chloroethynyl norgestrel mixed with mestranol (20:1)
* Mestranol mixed with chloroethynyl norgestrel (1:20)
* Wy-4355 mixed with Mestranol (20:1)

*** HEALTH HAZARD DATA ***

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 463 mg/kg/90W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumor types after systemic administration not seen
spontaneously
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 65,137,1980

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 423 mg/kg/4Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 3,179,1977

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 383 mg/kg/4Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
59,933,1977

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Digitalis lanata, extract 65323-80-0
18,19-Dinorpregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-, oxime, (17-alpha)- 82332-21-6
18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy- 16320-04-0
18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-, and testosterone 16320-04-0
A,19-Dinor-17-alpha-pregn-20-ene-2-beta,17-diol,2-ethynyl-20,21,21-trifluoro- 16320-04-0
18,19-Dinorpregn-4-ene-3,20-dione 2299-98-1
18,19-Dinor-17-alpha-pregn-4-en-3-one,13-ethyl-17-hydroxy- 797-58-0
18,19-Dinor-17-alpha-pregn-4-en-3-one,13-ethyl-17-hydroxy-, (+-)- 1235-15-0
18,19-Dinorpregn-4-en-20-yn-17-ol,13-ethyl-11-methylene-, (17-alpha)- 54024-22-5
18,19-Dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)- 35189-28-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,21-chloro-13-ethyl-17-hydroxy-, (+-)- 2415-28-3
Digitalis lanata standard 90028-00-5
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,21-chloro-13-ethyl-17-hydroxy-, mixed with3-methoxy-17-alpha-19-norpregna-1,3,5(10)trien-20-yn-17-ol 90028-00-5
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+)- 797-63-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+-)- 6533-00-2
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(8-alpha,9-beta,10-alpha,13-alpha, 14-beta)- 797-64-8
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy- mixed with 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol 797-64-8
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-11-methylene-, (17-alpha)- 54048-10-1
18,19-Dinorpregn-4-en-20-yn-3-one,12-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (5:3) 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (15:8) 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol (25:6) 39366-37-5
Digitalis lutea, leaf extract 39366-37-5
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17-alpha)-(+-)-, mixt. with(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol 8056-51-7
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (+-)-, and19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol 8056-51-7
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, oxime,(8-alpha,9-beta,10-alpha,13- alpha,14-beta)- 53016-31-2
18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one,17-hydroxy-13-propyl- 1044-96-8
A,19-Dinor-17-alpha-pregn-20-yne-2-beta,17-diol,2-ethynyl- 1044-96-8
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,(2-alpha,5-alpha,17-alpha)- 64675-09-8
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,diacetate, (2-beta,5-alpha,17-alpha)- 70226-89-0
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,dipropanoate, (2-alpha,5-alpha,17-alpha)- 64675-10-1
A,19-Dinorpregn-20-yne-2,17-diol, 2-ethynyl-,dipropanoate, (2-beta,5-alpha,17-alpha)- 64675-08-7
18,24-Dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic acid, 6-(acetyloxy)-7,15:21,23-diepoxy-4,8-dimethyl-1-oxo-, dimethylester, sodium salt,(4-alpha,5-alpha,6-alpha,7-alpha,15-beta,17-alpha)- 64675-08-7
Digitalis orientalis, leaf extract 64675-08-7
Diocytlamine, N-nitroso- 6335-97-3
Diodia sarmentosa Swartz, extractSUBSTANCE DEFINITION :Plant belonging to the family RubiaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year:42,179,1994 6335-97-3
Dioscine 469-88-5
Dioscorea alata Linn., rhizome extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea belophylla Voight, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984 469-88-5
Dioscoria bulbifera Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoriaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea bulbifera Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 469-88-5
Dioscorea dumetorum, alkaloidsSUBSTANCE DEFINITION :Extracted and purified from a species of the yam family, common in the wildstate, in NigeriaREFERENCE :NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)V.1- 1869- Volume(issue)/page/year: 177,935,1956 469-88-5
Dioscorea dumetorum (knuth) Pax., tuber extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979- 469-88-5
Dioscorea glabra Roxb., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984 469-88-5
Digitalis purpurea, extract 469-88-5
Dioscorea nipponica Mak., extract 469-88-5
Dioscorea oppositifolia Linn., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977 469-88-5
Dioscorea pentaphylla Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980 469-88-5
Dioscorea puber Bl., fruit and plant extractexcluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974 469-88-5
Dioscorea sativa L., extractSUBSTANCE DEFINITION :Plant belonging to the family DioscoreaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990 469-88-5

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