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MSDS  : Adenine, 9-beta-D-arabinofuranosyl-2-fluoro-
CAS  : 21679-14-1
SYNONYMS  : * 9-beta-D-Arabinofuranosyl-2-fluoroadenine * F-Ara-A
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AU6207000
CHEMICAL NAME : Adenine, 9-beta-D-arabinofuranosyl-2-fluoro-
CAS REGISTRY NUMBER : 21679-14-1
LAST UPDATED : 198909
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C10-H12-F-N5-O4
MOLECULAR WEIGHT : 285.27
WISWESSER LINE NOTATION : T56 BN DN FN HNJ GF IZ D- BT5OTJ CQ DQ E1Q
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* 9-beta-D-Arabinofuranosyl-2-fluoroadenine
* F-Ara-A

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 375 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,2587,1982

** MUTATION DATA **

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1500 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
40,1405,1980

TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 41 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,2587,1982

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 210,291,1989

*** END OF RECORD ***
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