RTECS NUMBER : AU6560000
CHEMICAL NAME : Adenine, N-methyl-N-nitroso-
CAS REGISTRY NUMBER : 21928-82-5
LAST UPDATED : 198910
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C6-H6-N6-O
MOLECULAR WEIGHT : 178.18
WISWESSER LINE NOTATION : T56 BN DM FN HNJ IN1&NO
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* 6-(Methylnitrosamino)purine
* N-Methyl-N-nitrosoadenine
* N-Methyl-N-nitroso-1H-purin-6-amine
* 6-Mna
* 1H-Purin-6-amine, N-methyl-N-nitroso-
* 1H-Purin-6-amine, N(sup 6)-methyl-N(sup 6)-nitroso-
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10263 mg/kg/72W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 24,319,1979
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 485 gm/kg/34W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 18,79,1977
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 15 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave.,
Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 31,787,1980
*** END OF RECORD ***
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