*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NR0200000
CHEMICAL NAME : Isocyanic acid, (m-trifluoromethylphenyl) ester
CAS REGISTRY NUMBER : 329-01-1
BEILSTEIN REFERENCE NO. : 0744880
REFERENCE : 4-12-00-01848 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C8-H4-F3-N-O
MOLECULAR WEIGHT : 187.13
SYNONYMS/TRADE NAMES :
* Isocyanobenzotrifluoride
* (alpha,alpha,alpha-Trifluoro-m-tolyl) isocyanate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 975 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(3),53,1976
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 328 mg/m3/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - deviated nasal septum
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535360
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 975 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(3),53,1976
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3300 mg/m3
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(3),53,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 871 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,2204,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 478 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(3),53,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11300 ug/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Cardiac - other changes
Liver - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(3),53,1976
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 11300 ug/m3/2H/11W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Cardiac - other changes
Liver - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(3),53,1976
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Isocyanic acid, cyclohexyl ester
| 3173-53-3 |
Isocyanic acid, 2,3-dibromoallyl ester
| 101652-14-6 |
Isocyanic acid, 3,4-dichlorophenyl ester
| 102-36-3 |
Isocyanic acid, 3,3'-dimethoxy-4,4'-biphenylene ester
| 91-93-0 |
Isocyanic acid, ester with di-o-toluenemethane
| 139-25-3 |
Indolizine, 3-(3-(diethylamino)propyl)-2-methyl-
| 65548-79-0 |
Isocyanic acid, ethyl ester
| 109-90-0 |
Isocyanic acid, 4-fluorobutyl ester
| 353-16-2 |
Isocyanic acid, 2-fluoroethyl ester
| 505-12-4 |
Isocyanic acid, 3-fluoropropyl ester
| 407-99-8 |
Isocyanic acid, m-(fluorosulfonyl)phenyl ester
| 402-36-8 |
Isocyanic acid, 2,2,3,3,4,4,4-heptafluorobutyl ester
| 377-00-4 |
Isocyanic acid, hexahydro-4,7-methanoinden-2,8-yleneester
| 377-00-4 |
Isocyanic acid, hexamethylene ester, polymers
| 28182-81-2 |
Isocyanic acid, 4-(p-isocyanatobenzyl)-m-phenyleneester
| 51944-41-3 |
Isocyanic acid,p-isopropenyl-alpha,alpha-dimethylbenzyl ester
| 2889-58-9 |
Indolizine, 1-(2-(dimethylamino)ethyl)-2-phenyl-
| 13452-60-3 |
Isocyanic acid, methylenedi-4,1-cyclohexylene ester
| 5124-30-1 |
Isocyanic acid, methylenedi-p-phenylene ester
| 101-68-8 |
Isocyanic acid,methylene(3,5,5-trimethyl-3,1-cyclohexylene) ester
| 4098-71-9 |
Isocyanic acid, methyl ester
| 624-83-9 |
Isocyanic acid, methyl-m-phenylene ester
| 26471-62-5 |
Isocyanic acid, 1,5-naphthylene ester
| 3173-72-6 |
Isocyanic acid, (p-(p-nitroanilino)phenyl)-
| 62967-27-5 |
Isocyanic acid, nitroiminodiethylenedi-
| 7046-61-9 |
Isocyanic acid, octadecyl ester
| 112-96-9 |
Isocyanic acid, m-phenylenedimethylene ester
| 3634-83-1 |
Indolizine, 1-((dimethylamino)methyl)-2-phenyl-
| 13452-58-9 |
Isocyanic acid, m-phenylene ester
| 123-61-5 |
Isocyanic acid, propyl ester
| 110-78-1 |
Isocyanic acid, triester with1,3,5-tris(6-hydroxyhexyl)biuret
| 4035-89-6 |
Isocyanic acid, (m-trifluoromethylphenyl) ester
| 329-01-1 |
Isocyanic acid, (alpha,alpha,alpha-trifluoro-o-tolyl)ester
| 2285-12-3 |
Isocyanic acid, p-xylylene ester
| 1014-98-8 |
Isodecyl alcohol
| 25339-17-7 |
Isoflavone, 8-(diethylaminomethyl)-7-hydroxy-,hydrochloride
| 67292-70-0 |
Isoflavone,8-(diethylaminomethyl)-7-hydroxy-2-methyl-,hydrochloride
| 67292-71-1 |
Isoflavone,7-(2-(dimethylamino)ethoxy)-4'-methoxy-2-methyl-
| 13004-41-6 |
Indolizine, 3-(3-(dimethylamino)propyl)-2-methyl-
| 65548-67-6 |
Isoflavone, 8-(dimethylaminomethyl)-7-hydroxy-,hydrochloride
| 67292-72-2 |
Isoflavone,8-(dimethylaminomethyl)-7-hydroxy-2-methyl-,hydrochloride
| 67292-77-7 |
Isoflavone, 7-hydroxy-2-methyl-8-(morpholinomethyl)-,hydrochloride
| 67292-73-3 |
Isoflavone, 7-hydroxy-2-methyl-8-(piperidinomethyl)-,hydrochloride
| 67292-74-4 |
Isoflavone, 7-hydroxy-8-(morpholinomethyl)-,hydrochloride
| 67292-75-5 |
Isoflavone, 7-hydroxy-8-(piperidinomethyl)-,hydrochloride
| 67292-76-6 |
Isoflavone, 4',5,7-trihydroxy-
| 446-72-0 |
Isoflavone, 4',5,7-trihydroxy-6-methoxy-
| 548-77-6 |
Isoflavonoid 1461
| 103842-84-8 |
Isoharringtonine
| 26833-86-3 |
Indolizine, 1-(3-(dimethylamino)propyl)-2-phenyl-
| 13452-59-0 |
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