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MSDS  : p-Phenylenediamine, N,N-diethyl-, sulfate (11)
CAS  : 6283-63-2
SYNONYMS  : * 1,4-Benzenediamine, N,N-diethyl-, sulfate (1:1) * N,N-Diethyl-p-phenylenediamine sulfate * N,N-Diethyl-1,4-phenylenediamine sulfate * Siran N,N-diethyl-p-fenylendiaminu
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : SS9625000
CHEMICAL NAME : p-Phenylenediamine, N,N-diethyl-, sulfate (1:1)
CAS REGISTRY NUMBER : 6283-63-2
LAST UPDATED : 199410
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C10-H16-N2.H2-O4-S
MOLECULAR WEIGHT : 262.36
WISWESSER LINE NOTATION : ZR DN2&2 &S-O4
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,4-Benzenediamine, N,N-diethyl-, sulfate (1:1)
* N,N-Diethyl-p-phenylenediamine sulfate
* N,N-Diethyl-1,4-phenylenediamine sulfate
* Siran N,N-diethyl-p-fenylendiaminu

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,479,1986

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - rigidity (including catalepsy)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 22(5),41,1957

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - rigidity (including catalepsy)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 22(5),41,1957

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - rigidity (including catalepsy)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 22(5),41,1957

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(9),71,1986

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - rigidity (including catalepsy)
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 22(5),41,1957

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - rigidity (including catalepsy)
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 22(5),41,1957

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 318 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(9),71,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 560 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(9),71,1986

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10920 ug/kg/26W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(9),71,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2745 mg/kg/61D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(9),71,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 244 mg/kg/61D-I
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 22(5),41,1957

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE : 36 mg/kg
SEX/DURATION : male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(9),71,1986

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 8 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 238,1,1990

*** END OF RECORD ***
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NAMECAS
p-Phenylenediamine, N,N-diethyl-, hydrochloride 2198-58-5
p-Phenylenediamine, N,N-diethyl-3-methyl-,hydrochloride 2051-79-8
p-Phenylenediamine, N,N-diethyl-, sulfate (11) 6283-63-2
p-Phenylenediamine, 2,6-difluoro- 3743-86-0
p-Phenylenediamine, N,N'-difurfurylidene- 19247-68-8
Phenol, 4-(pentachlorophenoxy)- 78576-72-4
m-Phenylenediamine, dihydrochloride 541-69-5
o-Phenylenediamine, dihydrochloride 615-28-1
p-Phenylenediamine, dihydrochloride 624-18-0
o-Phenylenediamine, N,N-dimethyl- 2836-03-5
p-Phenylenediamine, N,N-dimethyl- 99-98-9
p-Phenylenediamine, N-(1,3-dimethylbutyl)-N'-phenyl- 793-24-8
p-Phenylenediamine, N,N-dimethyl-, dihydrochloride 536-46-9
p-Phenylenediamine, N,N-dimethyl-, hemisulfate 60160-75-0
p-Phenylenediamine, N,N-dimethyl-, monohydrochloride 2052-46-2
m-Phenylenediamine,N,N-dimethyl-N'-(2-oxazolin-2-yl)- 101976-55-0
Phenol, pentachloro-, potassium salt 7778-73-6
p-Phenylenediamine,N,N-dimethyl-N'-(2-oxazolin-2-yl)- 101976-56-1
p-Phenylenediamine, N,N'-(di-2-naphthyl)- 93-46-9
m-Phenylenediamine, 2,4-dinitro-N(sup 3),N(sup3)-dipropyl-6-(trifluoromethyl)- 29091-21-2
p-Phenylenediamine, N,N'-diphenyl- 74-31-7
p-Phenylenediamine, N,N'-di-(o-tolyl)- 15017-02-4
m-Phenylenediamine, 4-ethoxy- 5862-77-1
m-Phenylenediamine, 4-ethoxy-, dihydrochloride 67801-06-3
m-Phenylenediamine, 4-(p-ethoxyphenylazo)- 94-10-0
m-Phenylenediamine, 4-((p-ethoxyphenyl)azo)-,monohydrochloride 2313-87-3
m-Phenylenediamine 4-ethyl- 1195-06-8
Phenol, pentachloro-, sodium salt 131-52-2
m-Phenylenediamine, 4-isopropoxy-, dihydrochloride 76486-07-2
p-Phenylenediamine, N-isopropyl-N'-phenyl- 101-72-4
o-Phenylenediamine, 4-methoxy- 102-51-2
p-Phenylenediamine, 2-methoxy- 5307-02-8
m-Phenylenediamine, 4-methoxy-, dihydrochloride 614-94-8
m-Phenylenediamine, 4-methoxy-, sulfate 39156-41-7
p-Phenylenediamine, 2-methoxy-, sulfate 66671-82-7
o-Phenylenediamine, N-methyl- 4760-34-3
p-Phenylenediamine, monohydrochloride 540-24-9
m-Phenylenediamine, 4-(1-naphthylazo)- 6416-57-5
Phenol, 3-(1-methyl-3-propyl-3-pyrrolidinyl)-,citrate 64047-77-4
Phenol, pentachloro-, sodium deriv mixed withtetrachlorophenol sodium deriv (4:1) 64047-77-4
m-Phenylenediamine, 4-nitro- 5131-58-8
o-Phenylenediamine, 3-nitro- 3694-52-8
o-Phenylenediamine, 4-nitro- 99-56-9
p-Phenylenediamine, 2-nitro- 5307-14-2
m-Phenylenediamine, 4,4'-pentamethylenedioxybis- 5307-14-2
o-Phenylenediamine, 4,4'-pentamethylenedioxybis- 109653-55-6
p-Phenylenediamine, N-phenyl- 101-54-2
m-Phenylenediamine, 4-(phenylazo)- 495-54-5
m-Phenylenediamine, 4-(phenylazo)-, hydrochloride 532-82-1
p-Phenylenediamine, N-phenyl-N'-cyclohexyl- 101-87-1

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