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MSDS  : p-Phenylenediamine, N,N'-diphenyl-
CAS  : 74-31-7
SYNONYMS  : * AgeRite DPPD * Altofane DIP * Antage DP * Antigene P * Antioxidant H * 1,4-Bis(phenylamino)benzene * N,N'-Difenyl-p-fenylendiamin * Diphenyl-p-phenylenediamine * N,N'-Diphenyl-p-phenylenediamine * DPPD * Ekaland DPPD * Flexamine G * JZF * Naugard J * Nocrac DP * Nonflex H * Nonox DPPD * Permanax 18 * Permanax DPPD * p-Phenylaminodiphenylamine * 4-Phenylaminodiphenylamine * USAF GY-2
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : ST2275000
CHEMICAL NAME : p-Phenylenediamine, N,N'-diphenyl-
CAS REGISTRY NUMBER : 74-31-7
BEILSTEIN REFERENCE NO. : 2215944
REFERENCE : 4-13-00-00116 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C18-H16-N2
MOLECULAR WEIGHT : 260.36
WISWESSER LINE NOTATION : RMR DMR
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* AgeRite DPPD
* Altofane DIP
* Antage DP
* Antigene P
* Antioxidant H
* 1,4-Bis(phenylamino)benzene
* N,N'-Difenyl-p-fenylendiamin
* Diphenyl-p-phenylenediamine
* N,N'-Diphenyl-p-phenylenediamine
* DPPD
* Ekaland DPPD
* Flexamine G
* JZF
* Naugard J
* Nocrac DP
* Nonflex H
* Nonox DPPD
* Permanax 18
* Permanax DPPD
* p-Phenylaminodiphenylamine
* 4-Phenylaminodiphenylamine
* USAF GY-2

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,485,1986

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,485,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 18 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 10(3),49,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 182 gm/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 7,278,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20443 mg/kg/3W-C
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
46,935,1982

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1000 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 450 mg/kg
SEX/DURATION : female 14 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 4,796,1956

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2500 mg/kg
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St.,
New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 110,29,1962

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 4176 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-160

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1975- Volume(issue)/page/year:
141,407,1984

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1800 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 30 mg/L
REFERENCE :
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu
1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year:
9(Suppl 2),27,1983

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80282
No. of Facilities: 315 (estimated)
No. of Industries: 5
No. of Occupations: 22
No. of Employees: 7496 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80282
No. of Facilities: 139 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 7680 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8803

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
p-Phenylenediamine, N,N-diethyl-, hydrochloride 2198-58-5
p-Phenylenediamine, N,N-diethyl-3-methyl-,hydrochloride 2051-79-8
p-Phenylenediamine, N,N-diethyl-, sulfate (11) 6283-63-2
p-Phenylenediamine, 2,6-difluoro- 3743-86-0
p-Phenylenediamine, N,N'-difurfurylidene- 19247-68-8
Phenol, 4-(pentachlorophenoxy)- 78576-72-4
m-Phenylenediamine, dihydrochloride 541-69-5
o-Phenylenediamine, dihydrochloride 615-28-1
p-Phenylenediamine, dihydrochloride 624-18-0
o-Phenylenediamine, N,N-dimethyl- 2836-03-5
p-Phenylenediamine, N,N-dimethyl- 99-98-9
p-Phenylenediamine, N-(1,3-dimethylbutyl)-N'-phenyl- 793-24-8
p-Phenylenediamine, N,N-dimethyl-, dihydrochloride 536-46-9
p-Phenylenediamine, N,N-dimethyl-, hemisulfate 60160-75-0
p-Phenylenediamine, N,N-dimethyl-, monohydrochloride 2052-46-2
m-Phenylenediamine,N,N-dimethyl-N'-(2-oxazolin-2-yl)- 101976-55-0
Phenol, pentachloro-, potassium salt 7778-73-6
p-Phenylenediamine,N,N-dimethyl-N'-(2-oxazolin-2-yl)- 101976-56-1
p-Phenylenediamine, N,N'-(di-2-naphthyl)- 93-46-9
m-Phenylenediamine, 2,4-dinitro-N(sup 3),N(sup3)-dipropyl-6-(trifluoromethyl)- 29091-21-2
p-Phenylenediamine, N,N'-diphenyl- 74-31-7
p-Phenylenediamine, N,N'-di-(o-tolyl)- 15017-02-4
m-Phenylenediamine, 4-ethoxy- 5862-77-1
m-Phenylenediamine, 4-ethoxy-, dihydrochloride 67801-06-3
m-Phenylenediamine, 4-(p-ethoxyphenylazo)- 94-10-0
m-Phenylenediamine, 4-((p-ethoxyphenyl)azo)-,monohydrochloride 2313-87-3
m-Phenylenediamine 4-ethyl- 1195-06-8
Phenol, pentachloro-, sodium salt 131-52-2
m-Phenylenediamine, 4-isopropoxy-, dihydrochloride 76486-07-2
p-Phenylenediamine, N-isopropyl-N'-phenyl- 101-72-4
o-Phenylenediamine, 4-methoxy- 102-51-2
p-Phenylenediamine, 2-methoxy- 5307-02-8
m-Phenylenediamine, 4-methoxy-, dihydrochloride 614-94-8
m-Phenylenediamine, 4-methoxy-, sulfate 39156-41-7
p-Phenylenediamine, 2-methoxy-, sulfate 66671-82-7
o-Phenylenediamine, N-methyl- 4760-34-3
p-Phenylenediamine, monohydrochloride 540-24-9
m-Phenylenediamine, 4-(1-naphthylazo)- 6416-57-5
Phenol, 3-(1-methyl-3-propyl-3-pyrrolidinyl)-,citrate 64047-77-4
Phenol, pentachloro-, sodium deriv mixed withtetrachlorophenol sodium deriv (4:1) 64047-77-4
m-Phenylenediamine, 4-nitro- 5131-58-8
o-Phenylenediamine, 3-nitro- 3694-52-8
o-Phenylenediamine, 4-nitro- 99-56-9
p-Phenylenediamine, 2-nitro- 5307-14-2
m-Phenylenediamine, 4,4'-pentamethylenedioxybis- 5307-14-2
o-Phenylenediamine, 4,4'-pentamethylenedioxybis- 109653-55-6
p-Phenylenediamine, N-phenyl- 101-54-2
m-Phenylenediamine, 4-(phenylazo)- 495-54-5
m-Phenylenediamine, 4-(phenylazo)-, hydrochloride 532-82-1
p-Phenylenediamine, N-phenyl-N'-cyclohexyl- 101-87-1

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