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MSDS  : p-Phenylenediamine, N,N-dimethyl-
CAS  : 99-98-9
SYNONYMS  : * p-Aminodimethylaniline * 1,4-Benzenediamine, N,N-dimethyl- * C.I. 76075 * p-(Dimethylamino)aniline * 4-(Dimethylamino)aniline * 4-(Dimethylamino)benzenamine * p-Dimethylaminophenylamine * 4-(Dimethylamino)phenylamine * Dimethyl-p-phenylenediamine * N,N-Dimethyl-p-fenylendiamin * N,N-Dimethyl-p-phenylenediamine * DMPD
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : ST0874000
CHEMICAL NAME : p-Phenylenediamine, N,N-dimethyl-
CAS REGISTRY NUMBER : 99-98-9
LAST UPDATED : 199710
DATA ITEMS CITED : 27
MOLECULAR FORMULA : C8-H12-N2
MOLECULAR WEIGHT : 136.22
WISWESSER LINE NOTATION : ZR DN1&1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Human
SYNONYMS/TRADE NAMES :
* p-Aminodimethylaniline
* 1,4-Benzenediamine, N,N-dimethyl-
* C.I. 76075
* p-(Dimethylamino)aniline
* 4-(Dimethylamino)aniline
* 4-(Dimethylamino)benzenamine
* p-Dimethylaminophenylamine
* 4-(Dimethylamino)phenylamine
* Dimethyl-p-phenylenediamine
* N,N-Dimethyl-p-fenylendiamin
* N,N-Dimethyl-p-phenylenediamine
* DMPD

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human
DOSE/DURATION : 14 ug/kg
TOXIC EFFECTS :
Blood - hemorrhage
Skin and Appendages - primary irritation (after topical exposure)
Skin and Appendages - dermatitis, allergic (after topical exposure)
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555326

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 95,262,1949

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555326

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 95,262,1949

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 84 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 95,262,1949

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 51 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 ppb
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 95,262,1949

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 240 ppb
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 500 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555326

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 45 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 95,262,1949

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 649 mg/kg/11D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555326

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 ug/plate
REFERENCE :
AEMIDF Applied and Environmental Microbiology. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976-
Volume(issue)/page/year: 42,641,1981

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,255,1984

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Liver
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,255,1984

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7141
No. of Facilities: 10 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 50 (estimated)
No. of Female Employees: 50 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
p-Phenylenediamine, N,N-diethyl-, hydrochloride 2198-58-5
p-Phenylenediamine, N,N-diethyl-3-methyl-,hydrochloride 2051-79-8
p-Phenylenediamine, N,N-diethyl-, sulfate (11) 6283-63-2
p-Phenylenediamine, 2,6-difluoro- 3743-86-0
p-Phenylenediamine, N,N'-difurfurylidene- 19247-68-8
Phenol, 4-(pentachlorophenoxy)- 78576-72-4
m-Phenylenediamine, dihydrochloride 541-69-5
o-Phenylenediamine, dihydrochloride 615-28-1
p-Phenylenediamine, dihydrochloride 624-18-0
o-Phenylenediamine, N,N-dimethyl- 2836-03-5
p-Phenylenediamine, N,N-dimethyl- 99-98-9
p-Phenylenediamine, N-(1,3-dimethylbutyl)-N'-phenyl- 793-24-8
p-Phenylenediamine, N,N-dimethyl-, dihydrochloride 536-46-9
p-Phenylenediamine, N,N-dimethyl-, hemisulfate 60160-75-0
p-Phenylenediamine, N,N-dimethyl-, monohydrochloride 2052-46-2
m-Phenylenediamine,N,N-dimethyl-N'-(2-oxazolin-2-yl)- 101976-55-0
Phenol, pentachloro-, potassium salt 7778-73-6
p-Phenylenediamine,N,N-dimethyl-N'-(2-oxazolin-2-yl)- 101976-56-1
p-Phenylenediamine, N,N'-(di-2-naphthyl)- 93-46-9
m-Phenylenediamine, 2,4-dinitro-N(sup 3),N(sup3)-dipropyl-6-(trifluoromethyl)- 29091-21-2
p-Phenylenediamine, N,N'-diphenyl- 74-31-7
p-Phenylenediamine, N,N'-di-(o-tolyl)- 15017-02-4
m-Phenylenediamine, 4-ethoxy- 5862-77-1
m-Phenylenediamine, 4-ethoxy-, dihydrochloride 67801-06-3
m-Phenylenediamine, 4-(p-ethoxyphenylazo)- 94-10-0
m-Phenylenediamine, 4-((p-ethoxyphenyl)azo)-,monohydrochloride 2313-87-3
m-Phenylenediamine 4-ethyl- 1195-06-8
Phenol, pentachloro-, sodium salt 131-52-2
m-Phenylenediamine, 4-isopropoxy-, dihydrochloride 76486-07-2
p-Phenylenediamine, N-isopropyl-N'-phenyl- 101-72-4
o-Phenylenediamine, 4-methoxy- 102-51-2
p-Phenylenediamine, 2-methoxy- 5307-02-8
m-Phenylenediamine, 4-methoxy-, dihydrochloride 614-94-8
m-Phenylenediamine, 4-methoxy-, sulfate 39156-41-7
p-Phenylenediamine, 2-methoxy-, sulfate 66671-82-7
o-Phenylenediamine, N-methyl- 4760-34-3
p-Phenylenediamine, monohydrochloride 540-24-9
m-Phenylenediamine, 4-(1-naphthylazo)- 6416-57-5
Phenol, 3-(1-methyl-3-propyl-3-pyrrolidinyl)-,citrate 64047-77-4
Phenol, pentachloro-, sodium deriv mixed withtetrachlorophenol sodium deriv (4:1) 64047-77-4
m-Phenylenediamine, 4-nitro- 5131-58-8
o-Phenylenediamine, 3-nitro- 3694-52-8
o-Phenylenediamine, 4-nitro- 99-56-9
p-Phenylenediamine, 2-nitro- 5307-14-2
m-Phenylenediamine, 4,4'-pentamethylenedioxybis- 5307-14-2
o-Phenylenediamine, 4,4'-pentamethylenedioxybis- 109653-55-6
p-Phenylenediamine, N-phenyl- 101-54-2
m-Phenylenediamine, 4-(phenylazo)- 495-54-5
m-Phenylenediamine, 4-(phenylazo)-, hydrochloride 532-82-1
p-Phenylenediamine, N-phenyl-N'-cyclohexyl- 101-87-1

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