protamine sulfate glycerin (glycerol) p-hydroxybenzoic acid, methyl ester (methylparaben) phenol (sara iii) water zinc-insulin crystals human:recombinant dna origin (bhi) m-cresol
LILLY ELI AND PHARMACEUTICAL D -- INSULIN, HUMAN, HUMULIN 70/30
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Material Safety Data Sheet
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NIIN: 01-309-3042
MSDS Num: BWMKD
MSDS NAME: INSULIN, HUMAN, HUMULIN 70/30
Responsible Party
Name: LILLY ELI AND CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
Info Phone: 317-276-2000/317-276-2286
Emergency Phone Number: 317-276-2000/800-424-9300(CHEMTREC)
Review Ind: Y
Published: Y
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Contractor Summary
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Name: LILLY ELI AND CO PHARMACEUTICAL DIV
Address: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN 46285
Phone: 317-276-2000
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Item Description Information
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Item Manager: S9M
Item Name: INSULIN HUMAN AND INSULIN HUMAN ISOPHANE
Specification Number: UNKNOWN
Unit of Issue: VI
UI Container Qty: 10 ML
Type of Container: VIAL
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Ingredients
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Cas: 9009-65-8
RTECS #: UK9450000
Name: PROTAMINE SULFATE
% Wt: 0-1.5
Other REC Limits: NONE RECOMMENDED
OSHA PEL: NOT ESTABLISHED
ACGIH TLV: NOT ESTABLISHED
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Cas: 56-81-5
RTECS #: MA8050000
Name: GLYCERIN (GLYCEROL)
% Wt: 1.4-1.8
Other REC Limits: NONE RECOMMENDED
OSHA PEL: 15 MG/M3 (MIST)
ACGIH TLV: 10 MG/M3 (MIST) 9394
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Cas: 99-76-3
RTECS #: DH2450000
Name: P-HYDROXYBENZOIC ACID, METHYL ESTER (METHYLPARABEN)
% Wt: 0-0.1
Other REC Limits: NONE RECOMMENDED
OSHA PEL: NOT ESTABLISHED
ACGIH TLV: NOT ESTABLISHED
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Cas: 108-95-2
RTECS #: SJ3327000
Name: PHENOL (SARA III)
% Wt: 0-0.28
Other REC Limits: NONE RECOMMENDED
OSHA PEL: S, 5 PPM
ACGIH TLV: S, 5 PPM; 9394
EPA Rpt Qty: 1000 LBS
DOT Rpt Qty: 1000 LBS
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Cas: 7732-18-5
RTECS #: ZC0110000
Name: WATER
% Wt: 95
Other REC Limits: NONE RECOMMENDED
OSHA PEL: NOT ESTABLISHED
ACGIH TLV: NOT ESTABLISHED
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Name: ZINC-INSULIN CRYSTALS HUMAN:RECOMBINANT DNA ORIGIN (BHI)
% Wt: 0.1-0.4
Other REC Limits: NONE RECOMMENDED
OSHA PEL: NOT ESTABLISHED
ACGIH TLV: NOT ESTABLISHED
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Cas: 108-39-4
RTECS #: GO6125000
Name: M-CRESOL
% Wt: 0-0.22
Other REC Limits: NONE RECOMMENDED
OSHA PEL: NOT ESTABLISHED
ACGIH TLV: NOT ESTABLISHED
EPA Rpt Qty: 1000 LBS
DOT Rpt Qty: 1000 LBS
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Health Hazards Data
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LD50 LC50 Mixture: UNKNOWN
Route Of Entry Inds - Inhalation: NO
Skin: YES
Ingestion: NO
Carcinogenicity Inds - NTP: NO
IARC: NO
OSHA: NO
Effects of Exposure: NONE REPORTED. PLEASE REFER TO PRODUCT LITERATURE FOR
INFORMATION ON ADVERSE REACTIONS IN CLINICAL USE.
Explanation Of Carcinogenicity: PER MSDS:NO CARCINOGENICITY DATA FOUND. NOT
LISTED AS CARCINOGENIC BY IARC/NCI/NTP/ACGIH/OSHA.
Signs And Symptions Of Overexposure: NONE REPORTED.
Medical Cond Aggravated By Exposure: NONE KNOWN.
First Aid: EYES:FLUSH W/PLENTY OF WATER.GET MED ATTN.SKIN:REMOVE CONTAMIN
CLOTH.WASH EXPO SKIN AREAS W/PLENTY OF SOAP & WATER.IRRIT DEVELOPS GET
MED ATTN.INHAL:MOVE TO FRESH AIR.BREATH DIFFI GET MED ATTN.NOT BRE ATH GIVE
ART RESP ASSIST(MOUTH-TO-MOUTH).CALL PHYSICIAN IMMED.INGEST:DO NOT INDUCE
VOMIT.CALL PHYSICIAN/POI CNTRL CNTR.GIVE ACTIVATED CHARCOAL(6-8 HEAPING
TEASPOONS)W/2-3 GLASSES OF WATER.GET MED ATTN
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Handling and Disposal
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Spill Release Procedures: PREVENT FURTHER MIGRATION INTO ENVIRONMENT. USE
ABSORBEN/ADSORBENT MATERIAL TO SOLIDIFY LIQUIDS. WEAR PROTECTIVE EQPMT
INCLUDING EYE PROTECTION TO AVOID EXPOSURE (SEE SPECIFIC HANDLING
PRECAUTIONS.
Waste Disposal Methods: DISPOSE OF ANY CLEANUP MATERIALS & WASTE RESIDUE
ACCORDING TO APPLICABLE LOCAL, STATE AND FEDERAL REGULATIONS. MATERIAL IS NOT
RCRA HAZARDOUS WASTE FOR DISPOSAL.
Handling And Storage Precautions: UNDER NORMAL USE & HANDLING CONDITIONS NO
PROTECTIVE EQUIPMENT IS REQUIRED.
Other Precautions: NONE SPECIFIED BY MFG.
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Fire and Explosion Hazard Information
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Extinguishing Media: USE WATER, CO2, DRY CHEMICAL, FOAM, OR HALON (NOTE HALON
IS AN ODS).
Fire Fighting Procedures: NONE SPECIFIED BY MFG.
Unusual Fire/Explosion Hazard: NONE KNOWN.
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Control Measures
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Respiratory Protection: NIOSH APPROVED RESPIRATORY OR LABORATORY FUME HOOD.
Ventilation: LABORATORY FUME HOOD OR LOCAL EXHAUST VENTILATION.
Protective Gloves: IMPERVIOUS GLOVES
Eye Protection: SAFETY GLASSES
Other Protective Equipment: UNDER NORMAL USE/HANDLING CONDITONS NO PROT EQPMT
REQUIRED.STATED PROT IS RECOMMENDED FOR PRODUCTION SETTING.BODY COVER.
Work Hygienic Practices: CLEAN CONTAMIN CLOTHING BEFORE REUSE.
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Physical/Chemical Properties
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HCC: N1
M.P/F.P Text: DECOMPOSES
Decomp Text: ANY HEAT
Spec Gravity: 1.004-1.007
PH: 7-7.8
Solubility in Water: SLIGHTLY SOLUBLE
Appearance and Odor: CLEAR SOLUTIONS TO WHITE MILKY SUSPENSIONS, ODORLESS
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Reactivity Data
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Stability Indicator: YES
Stability Condition To Avoid: DECOMPOSES WHEN HEATED.
Materials To Avoid: MAY REACT W/STRONG OXIDIZING AGENTS (E.G. PEROXIDES,
PERMANGANATES, NITRIC ACID, ETC).
Hazardous Decomposition Products: MAY EMIT TOXIC FUMES WHEN HEATED TO
DECOMPOSITION.
Hazardous Polymerization Indicator: NO
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Toxicological Information
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Ecological Information
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MSDS Transport Information
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Regulatory Information
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Other Information
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Transportation Information
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Trans ID NO: 124165
MSDS NAME: INSULIN, HUMAN, HUMULIN 70/30
MSDS Prepared Date: 10/01/1992
Review Date: 02/22/1995
Net Unit Weight: UNKNOWN
Multiple KIT Number: 0
Review IND: Y
Unit Of Issue: VI
Container QTY: 10 ML
Type Of Container: VIAL
Additional Data: PER MSDS:DTO/ICAO/IMO:NOT REGULATED FOR SURFACE/AIR/WATER
TRANSPORT.
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Detail DOT Information
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DOT PSN Code: ZZZ
DOT Proper Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION
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Detail IMO Information
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IMO PSN Code: ZZZ
IMO Proper Shipping Name: NOT REGULATED FOR THIS MODE OF TRANSPORTATION
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Detail IATA Information
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IATA PSN Code: ZZZ
IATA Proper Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION
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Detail AFI Information
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AFI PSN Code: ZZZ
AFI Proper Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION
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HAZCOM Label
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MSDS NAME: INSULIN, HUMAN, HUMULIN 70/30
Company: LILLY ELI AND CO PHARMACEUTICAL DIV
Street: LILLY CORPORATE CENTER
City: INDIANAPOLIS IN
Zipcode: 46285
Health Emergency Phone: 317-276-2000/800-424-9300(CHEMTREC)
Label Required IND: Y
Date Of Label Review: 02/22/1995
Status Code: C
Label Date: 02/22/1995
Origination Code: F
Skin Protection IND: YES
Signal Word: CAUTION
Health Hazard: Slight
Contact Hazard: Slight
Fire Hazard: None
Reactivity Hazard: None
Hazard And Precautions: PLEASE REFER TO PRODUCT LITERATURE FOR INFORMATION ON
ADVERSE REACTIONS IN CLINICAL USE. UNDER NORMAL USE & HANDLING CONDITIONS
NO PROTECTIVE EQUIPMENT IS REQUIRED. FIRST AID: EYES:FLUSH W/PLENTY OF W
ATER.GET MED ATTN.SKIN:REMOVE CONTAMIN CLOTH.WASH EXPO SKIN AREAS W/PLENTY OF
SOAP & WATER.IRRIT DEVELOPS GET MED ATTN.INHAL:MOVE TO FRESH AIR.BREATH
DIFFI GET MED ATTN.NOT BREATH GIVE ART RESP ASSIST (MOUTH-TO-MOUTH).CALL
PHYSICIAN IMMED.INGEST:DO NOT INDUCE VOMIT.CALL PHYSICIAN/POI CNTRL CNTR.GIVE
ACTIVATED CHARCOAL(6-8 HEAPING TEASPOONS)W/2-3 GLASSES OF WATER.GET MED ATTN
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Disclaimer (provided with this information by the compiling agencies): This
information is formulated for use by elements of the Department of Defense.
The United States of America in no manner whatsoever expressly or implied
warrants, states, or intends said information to have any application, use or
viability by or to any person or persons outside the Department of Defense
nor any person or persons contracting with any instrumentality of the United
States of America and disclaims all liability for such use. Any person
utilizing this instruction who is not a military or civilian employee of the
United States of America should seek competent professional advice to verify
and assume responsibility for the suitability of this information to their
particular situation regardless of similarity to a corresponding Department
of Defense or other government situation.