=====================  Product Identification  =====================

MSDS NAME:70870 VALPROIC ACID 500 MG
NIIN:00F052797
MSDS Number: CDCDF
=== Responsible Party ===
Company:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Info Phone Num:301-881-0666
Emergency Phone Num:301-881-0666
Preparer's Name:JEROME A HALPERIN
CAGE:14128
=== Contractor Identification ===
Company:UNITED STATES PHARMACOPEIAL CONVENTION INC
Address:12601 TWINBROOK PKWY
Box:City:ROCKVILLE
State:MD
ZIP:20852-1717
Country:US
Phone:301-881-0666
CAGE:14128

=============  Composition/Information on Ingredients  =============

Name:VALPROATE
CAS:99-66-1
RTECS #:YV7875000

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(RAT): 670 MG/KG
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:MAY CAUSE IRRITATION TO EYES, SKIN,
    RESPIRATORY TRACT, MUCOUS MEMBRANES. POSSIBLE HYPERSENSITIZATION &
    LIVER TOXICITY. INGESTION: MAY CAUSE IRRITATION. MATERIAL IS
    RAPIDLY & ALMOST COMPLETELY ABSORBED  FROM AN EMPTY STOMACH. USE OF
    VALPROICACID DURING PREGNANCY HAS BEEN REPORTED TO CAUSE AN
    INCREASED INCIDENCE (SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, LOSS OF APPETITE, INDIGESTION, MILD
    ABDOMINAL CRAMPS, NAUSEA, VOMITING, DIARRHEA, HAIR LOSS, TREMBLING
    HANDS & ARMS, MOOD/MENTAL CHANGES, TIREDNESS & WEAKNESS, SWELLING
    OF FACE, YELLOW EYE S/SKIN, VISUAL DISTURBANCES/UNCONTROLLABLE EYE
    MOVEMENTS, UNUSUAL BLEEDING/BRUISING, CLUMSINESS/UNSTEADINESS,
    (SUPP)
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO MATERIAL,
    ACTIVE ALCOHOLISM, IMPAIRED LIVER/KIDNEY FUNCTION, BLOOD
    DYSCRASIAS, ORGANIC BRAIN DISEASE, HYPOALBUMINEMIA.

=======================  First Aid Measures  =======================

First Aid:INHALATION: REMOVE TO FRESH AIR. EYES: FLUSH W/COPIOUS
    QUANTITIES OF TEPID WATER FOR 15 MINS. SKIN: FLUSH W/COPIOUS
    QUANTITIES OF SOAP & WATER. INGESTION: FLUSH MOUTH OUT W/WATER.
    PERSONS DEVELOPING S ERIOUS HYPERSENSITIVITY REACTIONS MUST RECEIVE
    IMMEDIATE MEDICAL ATTENTION. GIVE CPR/OXYGEN IF NEEDED. OBTAIN
    MEDICAL ATTENTION IN ALL CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
    FOR SURROUNDING FIRE & MATERIALS.
Fire Fighting Procedures:EVACUATE PERSONNEL TO SAFE AREA. WEAR SCBA &
    PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:THIS MATERIAL IS ASSUMED TO BE
    COMBUSTIBLE. EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR APPROVED RESPIRATOR & CHEMICALLY
    COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
    APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH
    SITE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE IN TIGHT CONTAINER AS DEFINED IN
    U.S. PHARMACOPIA. USE W/ADEQUATE DUST CONTROL. HANDLE/STORE
    IAW/INSTRUCTIONS TO ENSURE PRODUCT INTEGRITY.
Other Precautions:AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
    DUST/MIST. DON'T PERMIT EATING, DRINKING/SMOKING NEAR MATERIAL.
    GROUND MECHANICAL EQUIPMENT IN CONTACT W/DRY MATERIAL TO DISSIPATE
    POTENTIAL BUILDU P OF STATIC ELECTRICITY.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR A NIOSH APPROVED RESPIRATOR.
Ventilation:LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves:RUBBER
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
    REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
BOILING POINT: 429.8-431.6F. HEALTH HAZARDS: OF BIRTH DEFECTS IN THE
    HUMAN FETUS. SYMPTOMS: CONSTIPATION, DIZZINESS, HEADACHE, SKIN
    RASH, UNUSUAL EXCITEMENT, RESTLESSNESS, IRRITABILITY, DEEP COMA,
    ALL ERGIC REACTION, MENSTRUAL/WEIGHT CHANGES. ALL CHEMICALS SHOULD
    BE CONSIDERED POTENTIALLY HAZARDOUS.

==================  Physical/Chemical Properties  ==================

Boiling Pt:B.P. Text:(SEE SUPP)
Vapor Pres:0.01
Spec Gravity:0.922
Solubility in Water:SLIGHT
Appearance and Odor:CLEAR COLORLESS/PALE YELLOW, SLIGHTLY VISCOUS
    LIQUID W/CHARACTERISTIC ODOR.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:FIRE.
Hazardous Decomposition Products:WHEN HEATED TO DECOMPOSITION: ACRID
    SMOKE & IRRITATING FUMES.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
    REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

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