===================== Product Identification =====================
MSDS NAME:NIFLUMIC ACID N0630
NIIN:00N093261
Status Code:A
MSDS Number: CJWST
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076
============= Composition/Information on Ingredients =============
Name:NIFLUMIC ACID
CAS:4394-00-7
RTECS #:QT2999100
Code:F
===================== Hazards Identification =====================
LD50 LC50 Mixture:LD50: (ORAL,RAT) 250 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: HARMFUL IF SWALLOWED,
INHALED, OR ABSORBED THROUGH SKIN. CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY
TRACT. TO THE BEST OF OUR KNOWL EDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
Effects of Overexposure:SEE HEALTH HAZARDS.
======================= First Aid Measures =======================
First Aid:IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. IN CASE OF CONTACT,
IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS AMOUNTS OF WATER. IF
INHALED, REMOVE T O FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. IF SWALLOWED,
WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A
PHYSICIAN. WASH CONTAMIN ATED CLOTHING BEFOR REUSE.
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
================== Accidental Release Measures ==================
Spill Release Procedures:WEAR NIOSH APPRVD SELF-CONTAINED BREATHING
APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN
A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE
AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
====================== Handling and Storage ======================
Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. TOXIC. IRRITANT. KEEP TIGHTLY CLOSED.
LIGHT SENSITIVE. HYGROSCOPIC. STORE IN A COOL DRY PLACE.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NIOSH-APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:RUBBER GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH & DELUGE SHOWER MEETING ANSI DESIGN
CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:>203.C, 397.4F
M.P/F.P Text:203 C TO 204 C
Appearance and Odor:PALE-YELLOW POWDER.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:MAY DISCOLOR ON EXPOSURE TO LIGHT.
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
CARBON DIOXIDE, NITROGEN OXIDES, HYDROGEN FLUORIDE.
=================== Toxicological Information ===================
Toxicological Information:SEE HEALTH HAZARDS. RTECS #: ZT2999100.
NICOTINIC ACID, 2-(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINO)-.
TOXICITY DATA: ORL-RAT LD50:250 MG/KG JMCMAR 16,780,1973. IPR-RAT
LD50:155 MG/KG JMCMAR 19,135,197 6. ORL-MUS LD50:350 MG/KG USXXAM
#4122202. IPR-MUS LD50:196 MG/KG NYKZAU 68,683,1972. IVN-MUS
LD50:152 MG/KG THERAP 22,157,1967. TARGET ORGAN DATA: BEHAVIORAL
(ANALGESIA). EFTS ON FERTILITY (OTHER MEA SURES OF FERTILITY).
BIOCHEMICAL EFTS (EFT ON INFLAMM/ MEDIATION OF INFLAMM). ONLY
SELECTED REGISTRY OF TOXIC EFTS OF CHEM SUBSTANCES (RTECS) DATA IS
PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMP LETE INFO.
===================== Ecological Information =====================
Ecological:DATA NOT YET AVAILABLE.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.
=================== MSDS Transport Information ===================
Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.
===================== Regulatory Information =====================
Federal Regulatory Information:EUROPEAN INFORMATION. HARMFUL R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. R
36/37/38 IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN. S 26 IN
CASE OF CONTACT WITH EYES, RI NSE IMMEDIATELY WITH PLENTY OF WATER
AND SEEK MEDICAL ADVICE. S 36 WEAR SUITABLE PROTECTIVE CLOTHING.
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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