=====================  Product Identification  =====================

MSDS NAME:AMINOPHYLLINE, A1755
NIIN:00N093136
Status Code:A
MSDS Number: CJXKM
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Name:AMINOPHYLLINE  LD50: (ORAL, RAT) 243 MG/KG
CAS:317-34-0
RTECS #:XH5600000
= Wt:100.

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE INGREDIENT 1
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: HARMFUL IF SWALLOWED,
    INHALED OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION. TARGET
    ORGANS: CENTRAL NERVOUS SYSTEM. HEART, LUNGS. KIDNEYS. ADDITIONAL
    INFORMATION: ADVERSE REACTIONS: NA USEA, VOMITING, DIARRHEA,
    ANOREXIA, DYSPEPSIA, EPIGASTRIC PAIN, HEMATEMESIS, DIZZINESS,
    VERTIGO, HEADACHE, LIGHTHEADEDNESS, NERVOUSNESS, INSOMNIA,
    HYPERREFLEXIA, FASCICULATIONS, CLONIC AND TONIC CONVU LSIONS,
    PALPITATION TACHYCARDIA, EXTRASYSTOLES, HYPOTENSION, CIRCULATORY
    FAILURE, INCREASED RESPIRATORY RATES, URTICARIA. ALSO, SEE
    TOXICOLOGICAL INFORMATION.
Effects of Overexposure:SEE HEALTH HAZARDS.

=======================  First Aid Measures  =======================

Eyes: IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS
    AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IN CASE OF CONTACT,
    IMMEDIATELY FLUSH SKIN WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST
    15 M INUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES.
    INHALATION: IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE
    ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    INGESTION: IF  SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON
    IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE
    REUSE.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
    APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
    EQUIPMENT  TO PREVENT CONTACT WITH SKIN AND EYES.
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPROVED
    SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
    GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID
    RAISING DUST. VENTILATE AREA AN D WASH SPILL SITE AFTER MATERIAL
    PICKUP IS COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:DO NOT BREATHE DUST. AVOID CONTACT
    WITH EYES, SKIN AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
    WASH THOROUGHLY AFTER HANDLING. TOXIC. KEEP TIGHTLY CLOSED. AIR
    SENSITIVE. STORE UNDER NITROGEN.  STORE IN A COOL, DRY PLACE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH AND DELUGE SHOWER .
    WEAR OTHER PROTECTIVE CLOTHING.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:>269.C, 516.2F
M.P/F.P Text:269-270C
Appearance and Odor:WHITE POWDER.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS. MAY DISCOLOR ON EXPOSURE TO AIR.
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
    CARBON DIOXIDE, NITROGEN OXIDES.

===================  Toxicological Information	===================

Toxicological Information:RTECS #: XH5600000. THEOPHYLLINE, CMPD WITH
    ETHYLENEDIAMINE (2:1). TOX DATA: IVN-MAN LDLO: 1420 UG/KG JAMAAP
    123,1115,1943. REC-CHD LDLO: 221 MG/KG/3D. JAMAAP 161,693,1956.
    ORL-RAT LD50: 243 MG/KG BCF AAI 110,653,1971. IPR-RAT LD50: 129
    MG/KG EJMCA5 29,295,1994. SCU-RAT LD50: 176 MG/KG AEPPAE
    230,194,1957. IVN-RAT LD50: 104 MG/KG EJMCA5 29,295,1994. IMS-RAT
    LD50: 167 MG/KG ARZNAD 29,1013,1979. ORL- MUC LD50: 150 MG/KG
    JLCMAK 31,1337,1946. IRP-MUS LD50: 37 MG/KG STRAAA 127,245,1965.
    SCU-MUS LD50: 186 MG/KG ARZNAD 4,649,1954. IVN-MUS LD50: 125 MG/KG
    EJMCA5 29,295,1994. IMS-MUS LD50: 215 MG/KG CTYA D8 11,555,1980.
    (OTHER INFO)

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE. OTHER INFO: IVN-GPG LD50: 143 MG/KG
    ARZNAD 29,1013,1979. TARGET ORGAN DATA - BEHAVIORAL (TREMOR).
    BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD). BEHAVIORAL
    (MUSCLE CO NTRACTION OR SPASTICITY). BEHAVIORAL (COMA). BEHAVIORAL
    (WITHDRAWAL). CARDIAC (ARRHYTHMIAS). CARDIAC (OTHER CHANGES).
    LUNGS, THORAX OR RESPIRATION (RESPIRATORY STIMULATION). LUNGS,
    THORAX OR RESPIRATI ON (OTHER CHANGES). GASTROINTESTINAL (CHANGES
    IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS). GASTROINTESTINAL
    (NAUSEA OR VOMITING). ENDOCRINE (HYPERGLYCEMIA). (TRANSPORT INFO)

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION. ECOLOGICAL INFO: NUTRITIONAL AND GROSS METABOLIC
    (DEHYDRATION). NUTRITIONAL AND GROSS METABOLIC (CHANGES IN: K).
    NUTRITIONAL AND GROSS ME TABOLIC (CHANGES IN: METABOLIC ACIDOSIS).
    NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE INCREASE). ONLY
    SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
    DATA IS PRESENTED HERE. SE E ACTUAL ENTRY IN RTECS FOR COMPLETE
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:EUROPEAN INFORMATION - TOXIC. R 23/24/25
    TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. S 45 IN
    CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHE RE POSSIBLE). S 36/37/39 WEAR
    SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION.
    REVIEWS, STANDARDS AND REGULATIONS: OEL=MAK. OEL-RUSSIA:STEL 0.5
    MG/M3 JAN 1993. NOHS 1974: HZD 84313; NIS 4 ; TNF 2405; NOS 18; TNE
    10320. NOES 1983: HZD 84313; NIS 5; TNF 724; NOS 16; TNE 37320; TFE
    28051. E PA TSCA SECTION 8(B) CHEMICAL INVENTORY.

=======================  Other Information  =======================

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

*** END OF RECORD ***