=====================  Product Identification  =====================

MSDS NAME:THROMBIN FROM BOVINE PLASMA, T4265
NIIN:00N093152
Status Code:A
MSDS Number: CJXKD
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Name:THROMBIN
CAS:9002-04-4
RTECS #:XO8950000
= Wt:100.

=====================  Hazards Identification  =====================

Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE FATAL IF ENTERS
    BLOODSTREAM. MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN
    ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION.
    MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRA NES AND UPPER
    RESPIRATORY TRACT. PROLONGED OR REPEATED EXPOSURE MAY CAUSE
    ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. INVOLVED IN
    CLOTTING. TARGET ORGAN(S): VASCULAR SYSTEM. TO THE BEST OF MF R
    KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPERTIES
    HAVE NOT BEEN THOROUGHLY INVESTIGATED.
Effects of Overexposure:SEE HEALTH HAZARDS.

=======================  First Aid Measures  =======================

First Aid:IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH
    COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING
    CONTAMINATED CLOTHING AND SHOES. ASSURE ADEQUATE FLUSHING OF THE
    EYES BY SEPARAT ING THE EYELIDS WITH FINGERS. IF INHALED, REMOVE TO
    FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF
    BREATHING IS DIFFICULT, GIVE OXYGEN. IF SWALLOWED, WASH OUT MOUTH
    WITH WATER PROVIDED PE RSON IS CONSCIOUS. CALL PHYSICIAN. WASH
    CONTAMINATED CLOTHING BEFORE REUSE.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE
    TO SURROUNDING FIRE CONDITONS.
Fire Fighting Procedures:WEAR NIOSH APRPOVED SCBA AND FULL PROTECTIVE
    EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR NIOSH APPRVD RESPIRATOR, CHEMICAL SAFETY
    GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED MATERIAL
    SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND REMOVED.
    VENTILATE AREA AND WASH  SPILL SITE AFTER MATERIAL PICKUP IS
    COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID INHALATION. DO NOT GET IN EYES,
    ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. DO NOT
    USE IF SKIN IS CUT OR SCRATCHED. KEEP TIGHTLY CLOSED. STORE IN A
    COOL DRY PLACE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH-APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
    OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Solubility in Water:SOLUBLE
Appearance and Odor:SOLID.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:NATURE OF DECOMPOSITION PRODUCTS NOT
    KNOWN.

===================  Toxicological Information	===================

Toxicological Information:RTECS #: XO8950000. THROMBIN. TOX DATA:
    IPR-RAT LD50:>40 ML/KG OYYAA2 28,329,1984. SCU-RAT LD50:>40 ML/KG
    OYYAA2 28,329,1984. SKN-MUS LD50:>3 GM/KG YACHDS 1,272,1973.
    IPR-MUS LD50:>50 M./KG OYYAA2 28, 329,1984. SCU-MUS LD50:>50 ML/KG
    066AA2 28,329,1984. INV-MUS LD50:7771 UG/KG YACHDS 16,669,1988.
    TARGET ORGAN DATA: BEHAVIORAL (ALTERED SLEEP TIME). LUNGS, THORAX
    OR RESPIRATION (OTHER CHANGES). KIDNE Y, URETER, BLADDER (OTHER
    CHANGES). ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL
    SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN
    RTECS FOR COMPLETE INFORMATION.

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:REVIEWS, STANDARDS, AND REGULATIONS.
    OEL=MAK. NOES 1983: HAZD X3641; NIS 3; TNF 339, NOS 7; TNE 7383;
    TFE 5915. EPA TSCA SECTION 8(B) CHEMICAL INVENTORY.

=======================  Other Information  =======================

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

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