=====================  Product Identification  =====================

MSDS NAME:MITOMYCIN C FROM STREPTOMYCES CAESPITOSUS, M0503
NIIN:00N093130
Status Code:A
MSDS Number: CJXKW
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Name:MITOMYCIN C. EN #: 200-008-6.
CAS:50-07-7
RTECS #:CN0700000
= Wt:100.
Other REC Limits:N/K 
OSHA PEL:N/K 
OSHA STEL:N/K 
ACGIH TLV:N/K 
ACGIH STEL:N/K 
EPA Rpt Qty:10 LBS
DOT Rpt Qty:10 LBS

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:YES	 OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE FATAL IF INHALED,
    SWALLOWED, OR ABSORBED THROUGH SKIN. CAUSES EYE AND SKIN
    IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT. CHRONIC: CARCINOGEN. MAY AL TER GENETIC
    MATERIAL. OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDERS BASED ON
    TESTS WITH LABORATORY ANIMALS. TARGET ORGANS: BONE MARROW, LIVER.
Explanation of Carcinogenicity:MITOMYCIN: IARC MONOGRAPHS, SUPPLEMENT,
    VOLUME 7, PAGE 56, 1987: GROUP 2B.
Effects of Overexposure:SEE HEALTH HAZARDS. -- OTHER INFORMATION:
    NUTRITIONAL AND GROSS METABOLIC (WEIGHT LOSS OR DECREASED WEIGHT
    GAIN); TUMORIGENIC (CARCINOGENIC BY RTECS CRITERIA, NEOPLASTIC BY
    RTECS CRITERIA, TUMORS AT S ITE OF APPLICATION). ONLY SELECTED
    REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS
    PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION.

=======================  First Aid Measures  =======================

First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
    SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
    ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
    APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
    APPARATUS AND FULL PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:EVACUATE AREA. SHUT OFF ALL SOURCES OF
    IGNITION. WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS,
    RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND
    HOLD FOR WASTE DISPOSAL. AVO ID RAISING DUST. VENTILATE AREA AND
    WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
    EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
    CARCINOGEN. HIGHLY TOXIC. MUTAGEN. POSSIBLE TERATOGEN. IRRITANT.
    KEEP TIGHLY CLOSED.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
    SHOWER . PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
EC #: 200-008-6. TOX INFO: NIIRDN -, 1129, 1990. IVN-RBT LD50: 3400
    UG/KG; NIIRDN -, 1129, 1990. ORL-QAL LD50: >100 MG/KG; EESADV 6,
    149, 1982. ORL-BWD LD50: 7500 UG/KG; AECTCV 12, 355, 1983. TARGET O
    RGAN DATA: BEHAVIORAL (SOMNOLENCE, ATAXIA); LUNGS, THORAX/RESP
    (FIBROSING ALVEOLITIS, DYSPNAE); (OTHER INFO)

==================  Physical/Chemical Properties  ==================

Appearance and Odor:SOLID.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS, STRONG ACIDS, STRONG BASES.
Hazardous Decomposition Products:TOXIC FUMES OF CARBON MONOXIDE, CARBON
    DIOXIDE, NITROGEN OXIDES.

===================  Toxicological Information	===================

Toxicological Information:RTECS # CN0700000 - AZIRINO (2', 3': 3, 4)
    PYRROLO (1, 2-A) INDOLE-4, 7-DIONE, 6-AMINO-1, 1A, 2, 8, 8A,
    8B-HEXAHYDRO-8-(HYDROXY METHYL)-8A-METHOXY-5-METHYL-, CARBAMATE
    (ESTER). TOX DATA: ORL-RAT LD50:  30 MG/KG; CNREA8 20, 1354, 1960.
    IPR-RAT LD50: 2 MG/KG; ADTEAS 3, 181, 1968. SCU-RAT LD50: 3250
    UG/KG; NIIRDN 6, 798, 1982. IVN-RAT LD50: 3 MG/KG; ARZNAD 20, 1467,
    1970. ORL-MUS LD50: 23 MG/KG; CNREA 8 20, 1354, 1960. IPR-MUS LD50:
    4 MG/KG; JAJAAA 13, 27, 1960. SCU-MUS LD50: 7300 UG/KG; JJCREP 80,
    670, 1989. IVN-MUS LD50: 4 MG/KG; JAJAAA 13, 27, 1960. UNR-MUS
    LD50: 12 MG/KG; CNREA8 46, 2703, 1986.  IVN-DOG LD50: 720 UG/KG;
    (SUP DAT)

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE. -- FED REGS: IARC CANCER REVIEW:
    HUMAN NO ADEQ DATA; IMEMDT 10, 171, 1976. IARC CANCER REVIEW: GROUP
    2B; IMSUDL 7, 56, 1987. NOES 1983: HZD X4281; NIS 1; TNF 39; NOS 3;
    TNE 108 7; TFE 588. EPA GENETOX PROGRAM 1988, POS:
    CARCIN-MOUSE/RAT; IN VITRO CYTOGENETICS-NONHUMAN. EPA GENETOX
    PROGRAM 1988, POS: IN VIVO CYTOGENETICS-NONHUMAN BONE MARROW. EPA
    GENETOX PROGRAM 1988, POS: NI  VIVO CYTOGENETICS-MAMMALIAN OOCYTE.
    EPA GENETOX PROGRAM 1988, POS: CYTOGENETICS-MALE GERM CELL; RODENT
    DOMINANT LETHAL. EPA GENETOX PROGRAM 1988, POS: HOST-MEDIATED
    ASSAY; RODENT HERITABLE TRANSLOCAT ION. (TRANSPORT INFO)

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS. RC RA WASTE NUMBER U010.

===================  MSDS Transport Information  ===================

Transport Information:CONT SIGMA CHEM COMPANY FOR TRANSPORTATION INFO.
    -- ECOLOGICAL INFO: EPA GENETOX PROGRAM 1988, POS: L5178Y CELLS IN
    VITRO-TK TEST; MAMMALIAN MICRONUCLEUS. EPA GENETOX PROGRAM 1988,
    POS: NI VITRO HUMAN  LYNPHOCYTE MICRONUCLEUS; MOUSE SPOT TEST. EPA
    GENETOX PROGRAM 1988, POS: N CRASSA-FORWARD MUTATION; B SUBTILIS
    REC ASSAY. EPA GENETOX PROGRAM 1988, POS: E COLI POLA W/OUT S9;
    MOUSE SPECIFIC LOCUS. EP A GENETOX PROGRAM 1988, POS: SPERM
    MORPHOLOGY-MOUSE; D MELANOGASTER SEX-LINKED LETHAL. EPA GENETOX
    PROGRAM 1988, POS: IN VITRO UDS-HUMAN FIBROBLAST; TRP REVERSION.
    EPA GENETOX PROGRAM 1988, POS: S CER EVISIAE GENE CONVERSION; (SARA
    REGS)

=====================  Regulatory Information  =====================

SARA Title III Information:N/P -- TRANSPORT INFO: S
    CEREVISIAE-HOMOZYGOSIS. EPA GENETOX PROGRAM 1988, POS: S
    CEREVISIAE-ANEUPLOIDY; S CEREVISIAE-REVERSION. EPA GENETOX PROGRAM
    1988, POS/DOSE RESPONSE: NI VITRO SCE-HUMAN LYMPHOC YTES. EPA
    GENETOX PROGRAM 1988, POS/DOSE RESPONSE: IN VITRO SCE-WI-38 CELLS;
    IN VITRO SCE-HUMAN. EPA GENETOX PROGRAM 1988, POS/DOSE RESPONSE: IN
    VITRO SCE-NONHUMAN; IN VIVO SCE-NONHUMAN. EPA GENETOX P ROGRAM
    1988, NEG: N CRASSA-ANEUPLOIDY; UDS IN MOUSE GERM CELLS. EPA
    GENETOX PROGRAM 1988, NEG: TRP REVERSION. EPA GENETOX PROGRAM 1988,
    INCONCLUSIVE: HISTIDINE REVERSION-AMES TEST. (STATE REGS)
Federal Regulatory Information:EUROPEAN INFO: VERY TOX. R 45: MAY CAUSE
    CANCER. R 46: MAY CAUSE HERITABLE GENETIC DMG. R 26/27/28: VERY TOX
    BY INHAL, IN CONT W/SKIN & IF SWALLOWED. R 36/37/38: IRRITATING TO
    EYES, RESP SYS & SKIN. R  63: POSS RISK OF HARM TO UNBORN CHILD. S
    45: IN CASE OF ACCIDENT/IF YOU FEEL UNWELL, SEEK MED ADVICE IMMED
    (SHOW LABEL WHERE POSS). S 26: IN CASE OF CONT W/EYES, RINSE IMMED
    W/PLENTY OF WATER & SEEK  MED ADVICE. S 36/37/39: WEAR SUITABLE
    PROT CLTHG, GLOVES & EYE/FACE PROT. S 22: DO NOT BREATHE DUST. 
    REVIEWS, STDS, & REGS: OEL=MAK. IARC CANCER REVIEW: ANIMAL
    SUFFICIENT EVIDENCE; IMEMDT 10, 171, 1976. (ECOLOGICAL INFO)
State Regulatory Information:CALIFORNIA PROPOSITION 65: THIS PROD
    IS/CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE
    CANCER. -- SARA REGS: EPA GENETOX PROGRAM 1988, INCONCLUSIVE: SPERM
    MORPHOLOGY-MOUSE F1.EPA GENET OX PROGRAM 1988, POS: CHO GENE
    MUTATION. EPA TSCA SECTION 8 (B) CHEM INVENTORY. EPA TSCA SECTION 8
    (D) UNPUBLISHED HLTH/SFTY STUDIES. EPA TSCA TEST SUBMISSION
    (TSCATS) DATA BASE, JUNE 1998. NCI CARCIN OGENESIS STUDIES (IPR);
    CLEAR EVIDENCE: RAT; RRCRBU 52, 1, 75. NCI CARCINOGENESIS STUDIES
    (IPR); NO  EVIDENCE: MOUSE; RRCRBU 52, 1, 75.

=======================  Other Information  =======================

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
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*** END OF RECORD ***