=====================  Product Identification  =====================

MSDS NAME:MEFENAMIC ACID, M4267
NIIN:00N093128
Status Code:A
MSDS Number: CJXLC
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Name:ANTHRANILIC ACID, N-(2,3-XYLYL)-; (MEFENAMIC ACID).
    LD50:(ORAL,RAT) 740 MG/KG.
CAS:61-68-7
RTECS #:CB4550000
= Wt:100.

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE INGREDIENTS & TOXICOLOGICAL INFO.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED
    OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION. MAY CAUSE NERVOUS
    SYSTEM DISTURBANCES. EXPOSURE CAN CAUSE: GASTROINTESTINAL
    DISTURBANCES; BLOOD EFFECTS. CHRONIC: P OSSIBLE TERATOGEN. MAY
    CAUSE REPRODUCTIVE DISORDERS. TARGET ORGAN(S): KIDNEYS. TARGET
    ORGAN DATA: PERIPHERAL NERVE AND SENSATION (FLACCID PARALYSIS
    WITHOUT ANESTHESIA). SENSE ORGANS AND SPECIAL SENSES  (MYDRIASIS).
    BEHAVIORAL (ALTERED SLEEP TIME; SOMNOLENCE; TOXIC PSYCHOSIS;
    CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; ATAXIA; WITHDRAWAL).
    LUNGS, THORAX OR RESPIRATION (RESPIRATORY STIMULATION). GAST
    ROINTESTINAL (CHANGES (EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZ: IN STRUCTURE OR FUNCTION OF EXOCRINE
    PANCREAS; ULCERATION OR BLEEDING FROM LARGE INTESTINE;
    HYPERMOTILITY, DIARRHEA). LIVER (LIVER FUNCTION TESTS IMPAIRED).
    KIDNEY, URETER, BLADDER (CHANGES  IN TUBULES). BLOOD (OTHER
    HEMOLYSIS WITH OR WITHOUT ANEMIA). SKIN AND APPENDAGES (AFTER
    SYSTEMIC EXPOSURE: DERMATITIS, OTHER). MATERNAL EFFECTS (MENSTRUAL
    CYCLE CHANGES OR DISORDERS). SPECIFIC DEVELOP MENTAL ABNORMALITIES
    (CRANIOFACIAL; CARDIOVASCULAR SYSTEM). NUTRITIONAL AND GROSS
    METABOLIC (CHANGES IN: K; BODY TEMPERATURE INCREASE; OTHER
    CHANGES). TUMORIGENIC (ACTIVE AS ANTI-CANCER AGENT).

=======================  First Aid Measures  =======================

First Aid:INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
    CONSCIOUS. CALL MD. SKIN: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR
    AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES. CALL
    MD. INHALATI ON: REMOVE TO FRESH AIR. IF BREATHING BECOMES
    DIFFICULT, CALL MD. EYES: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR
    AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING THE
    EYELIDS WITH FINGERS. CA LL MD.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE
    FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
    EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
    SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP,
    PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS
    COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:HARMFUL. HARMFUL BY INHALATION, IN
    CONTACT WITH SKIN AND IF SWALLOWED. DO NOT BREATHE DUST.
Other Precautions:POSSIBLE RISK OF IRREVERSIBLE EFFECTS. POSSIBLE
    TERATOGEN. REPRODUCTIVE HAZARD. NEUROLOGICAL HAZARD.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYE WASH AND DELUGE
    SHOWER . WEAR SUITABLE OTHER PROTECTIVE CLOTHING.
Supplemental Safety and Health
MFR'S INFORMATION ON INGREDIENTS: MF: C15H15NO2. EC NO: 200-513-1. --
    PHYSICAL AND CHEMICAL PROPERTIES: SOLUBILITY: IN AMMONIUM -
    SOLUBLE.

==================  Physical/Chemical Properties  ==================

Solubility in Water:SUPP DATA
Appearance and Odor:SOLID.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
    CARBON DIOXIDE, NITROGEN OXIDES.
Conditions to Avoid Polymerization:WILL NOT OCCUR.

===================  Toxicological Information	===================

Toxicological Information:TOXICITY DATA: LDLO:(ORAL,WMN) 280 MG/KG/2W-I
    - DRSAEA 6,230,1991. LD50:(ORAL,RAT) 740 MG/KG - TOIZAG 28,99,1981.
    LD50:(IPR,RAT) 327 MG/KG - TXAPA9 18,185,1971. LD50:(IVN,RAT) 112
    MG/KG; LD50:(IVN,CAT ) 100 MG/KG - CMROCX 4,17,1976.
    LD50:(ORAL,MUS) 525 MG/KG. - JNPHAG 2,259,1971. LD50:(IPR,MUS) 120
    MG/KG - ARZNAD 19,36,1969. LD50:(IVN,MUS) 96 MG/KG - YKKZAJ
    89,1392,1969. LD50:(IMS,MUS) 400 MG/KG -  PCJOAU 17,353,1983. ONLY
    SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
    DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE
    INFORMATION.

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:EUROPEAN INFORMATION: HARMFUL; R
    20/21/22 - HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF
    SWALLOWED. R 40 - POSSIBLE RISK OF IRREVERSIBLE EFFECTS. S 22 - DO
    NOT BREATHE DUST. S 36 - WEAR SUITABLE  PROTECTIVE CLOTHING.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

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