=====================  Product Identification  =====================

MSDS NAME:THIOGUANINE
NIIN:01-146-8047
MSDS Number: BHHQJ
=== Responsible Party ===
Company:BURROUGHS WELLCOME CO.
Address:3030 CORNWALLIS ROAD
City:RESEARCH TRIANGLE PARK
State:NC
ZIP:27709-4416
Country:US
Info Phone Num:919-248-3000
Emergency Phone Num:919-248-3000
CAGE:5P291
=== Contractor Identification ===
Company:BURROUGHS WELLCOME CO NATIONAL ACCOUNTS DIV
Address:3030 CORNWALLIS RD
Box:City:RESEARCH TRIANGLE PARK
State:NC
ZIP:27709-4416
Country:US
CAGE:5P291

=============  Composition/Information on Ingredients  =============

Name:THIOGUANINE (6-THIOGUANINE OR
    2-AMINO-1,7-DIHYDRO-6H-PURINE-6-THIONE)
CAS:154-42-7
RTECS #:UP0740000

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50 ORAL RAT = 740 MG/KG
Routes of Entry: Inhalation:NO	Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:THIOGUANINE HAS BEEN SHOWN TO BE
    TERATOGENIC IN RATS. DRUGS SUCH AS THIOGUANINE ARE POTENTIAL
    CARCINOGENS, MUTAGENS AND TERATOGENS. THIOGUANINE MAY CAUSE FETAL
    HARM WHEN ADMINITERED TO A PREGNANT WOMA N.
Explanation of Carcinogenicity:MANUFACTURER STATES THIOGUANINE IS A
    POTENTIAL CARCINOGEN, BUT IT IS NOT LISTED UNDER IARC,NTP OR OSHA.
Effects of Overexposure:NAUSEA, VOMITING, ANOREXIA, MALAISE,
    HYPERTENSION, DIAPHORESIS, AND STOMATITIS MAY OCCUR. THE
    SUPPRESSIVE EFFECT ON BONE MARROW AND AZOTEMIA IS LIKELY TO BE
    DELAYED FOR SEVERAL DAYS.
Medical Cond Aggravated by Exposure:MANUFACTURER DID NOT SPECIFY.

=======================  First Aid Measures  =======================

First Aid:IF INGESTED, WASH MOUTH. IF INGESTION WAS RECENT, INDUCE
    VOMIT, GASTRIC LAVAGE AND ADMINISTRATION OF CHARCOAL MAY REDUCE
    ABSORPTION. CONTACT PHYSICIAN.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:USE CARBON DIOXIDE, FOAM, DRY CHEMICAL, OR WATER
    FOG.
Fire Fighting Procedures:FIRE FIGHTERS SHOULD USE NIOSH APPROVED SCBA &
    FULL PROTECTIVE EQUIPMENT WHEN FIGHTING CHEMICAL FIRE. USE WATER
    SPRAY TO COOL NEARBY CONTAINERS EXPOSED TO FIRE.
Unusual Fire/Explosion Hazard:FIRE OR EXCESSIVE HEAT MAY CAUSE
    PRODUCTION OF HAZARDOUS DECOMPOSITION PRODUCTS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:SWEEP UP AND PLACE IN APPROPIATE DISPOSAL
    CONTAINER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:KEEP IN ORIGINAL CONTAINER TIGHTLY
    CLOSED. PROTECT FROM LIGHT.
Other Precautions:NONE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NONE REQUIRED.
Ventilation:NORMAL ROOM VENTILATION.
Protective Gloves:NONE REQUIRED.
Eye Protection:NONE REQUIRED.
Other Protective Equipment:NONE.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
MSDS SUPPLIED BY MANUFACTURER WAS FOR BULK AMOUNT. HMIS MODIFIED MSDS
    FOR TABLET FORM. THIOGUANINE IS AN ANTINEOPLASTIC DRUG.

==================  Physical/Chemical Properties  ==================

HCC:N1
Solubility in Water:APPRECIABLE.
Appearance and Odor:SLIGHTLY YELLOW POWDER WITH NO ODOR.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES

====================  Disposal Considerations  ====================

Waste Disposal Methods:CONTACT YOUR LOCAL ENVIRONMENTAL OFFICER.
    ARRANGE FOR CHEMICAL INCINERATION OR SUPERVISED BURIAL AT AN
    APPROVED TOXIC WASTE FACILITY. DISPOSE OF IN ACCORDANCE WITH ALL
    APPLICABLE FEDERAL, STATE AND LO CAL REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

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