MATERIAL SAFETY DATA SHEET
MSDS No. EW417610
Revised Date: 2003/01/15
CODE: 415-76101, 996-76101
IDENTITY LBA AFP-L3
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME : LBA AFP-L3
MANUFACTURER : Wako Pure Chemical Industries, Ltd.
SUPPLIER : SUPPLIER(In JAPAN) : Wako Pure Chemical Industries, Ltd.
ADDRESS : 1-2, Doshomachi 3-chome, Chuo-ku, Osaka, 540-8605, Japan
TELEPHONE NUMBER & EMERGENCY TELEPHONE NUMBER: (06)6203-3741
SUPPLIER(In U.S.A.) : Wako Chemicals USA, Inc.
ADDRESS : 1600 Bellwood Road, Richmond, VA 23237, U.S.A.
TELEPHONE NUMBER : (804)271-7677
EMERGENCY TELEPHONE NUMBER : (800)424-9300 (CHEMTREC)
SUPPLIER(In EUROPE) : Wako Chemicals GmbH, Germany
ADDRESS : Nissanstrasse 2,D-41468 Neuss, GERMANY
TELEPHONE NUMBER & EMERGENCY TELEPHONE NUMBER : (02131)311-0
2. COMPOSITION/INFORMATION ON INGREDIENTS
CHEMICAL NAME CONTENT
[1] Reagent 1 :
LCA ;(1) 0.15w/v%
Anion 1 conjugated anti-AFP monoclonal antibody(mouse) ;(2) -
[2] Reagent 2 :
Peroxidase(horseradixh) labeled anti-HABP monoclonal antibody(mouse) ;(3) -
Anion 2 conjugated anti-AFP monoclonal antibody(mouse) ;(4) -
[3] Substrate 1 :
4-Acetoamidophenol ;(5) 4.8w/v%
2-Propanol ;(6) Approx. 95w/v%
[4] Substrate 2 :
Hydrogen peroxide ;(7) 0.14w/v%
SYNONYMS : (5); p-Acetamidophenol; p-Hydroxyacetanilide; Acetaminofen
(6); Isopropyl alcohol, Isopropanol, Secondary propyl alcohol, Dimethyl carbinol,
Petrohol, IPA
(7); Hydrogen dioxide
FORMULA : (5); C8H9NO2
(6); C3H8O
(7); H2O2
(1)-(4);
Not available
MOLECULAR WEIGHT : (5); 151.16
(6); 60.10
(7); 34.01
(1)-(4);
Not available
CAS NUMBER : (5); 103-90-2
(6); 67-63-0
(7); 7722-84-1
(1)-(4);
Not listed
TSCA INVETORY : (1)-(4);
Not listed (See Section 15)
(5)-(7);
Listed
EINECS No. : (5); 203-157-5
(6); 200-661-7
(7); 231-765-0
(1)-(4);
Not listed
IDENTIFICATION OF DANGER ;
[3]; SYMBOL : F, Xi
R-phrases : 11-36-67
[1],[2],[4]; SYMBOL : -----
R-phrases : -----
3. HAZARDS IDENTIFICATION
Highly flammable.
Irritating to eyes.
Vapours may cause drowsiness and dizziness.
May be harmful if inhaled and ingested.
Causes skin irritation.
Defatting action on the skin.
(6); NFPA : HR= health-1, flam.-3, react.-0, HMIS : HR= health-1, flam.-3, react.-0
4. FIRST AID MEASURES
GENERAL ADVICE : Wash off immediately with soap and plenty of water. In the case of respirable dust and/or fumes, use
self-contained breathing apparatus and dust impervious protective suit. Use personal protective
equipment.
INHALATION : [1]-[4]; Move victim to fresh air. If breathing is difficult, give oxygen. If irritation persists, consult a physician.
SKIN CONTACT : [1]-[4]; Remove contaminated clothes and shoes, rinse skin with plenty of water or shower. Use soap to
help assure removal. If irritation persists, consult a physician.
EYE CONTACT : [1]-[4]; Remove any contact lenses at once. Flush eyes well with flooding amounts of running water for at
least 15 minutes. Assure adequate flushing by separating the eyelids with sterile fingers. If irritation
persists, consult a physician.
INGESTION : [1]-[4]; Rinse mouth, give plenty of water to dilute the substance. Never give anything by mouth to an
unconscious person. Consult a physician.
5. FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA : Carbon dioxide, dry chemical powder, alcohol resistant foam,
water
FIRE & EXPLOSION HAZARDS : [1],[2],[4]; Toxic, irritating fumes or smoke may be emitted.
[3]; Flammable liquid. Hazardous toxic and irritating
fumes or smoke may be emitted. Vapors may travel
considerable distance to ignition source and flash
back.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS : Firemen should wear normal protective equipment(full bunker
gear)and positive-pressure self-contained breathing apparatus.
6. ACCIDENTAL RELEASE MEASURES
PERSONAL PRECAUTIONS : Remove ignition sources and ventilate area. In case of insufficient ventilation, wear
suitable respiratory equipment. Avoid contact with skin and eyes.
ENVIRONMENTAL PRECAUTIONS : Prevent spills from entering sewers, watercourses or low areas.
METHODS FOR CLEAN UP : [1]-[4]; Do not touch spilled material without suitable protection(See section 8). Take up
spilled material with ashes or other absorbents. After material is completely
picked up, wash the spill site with soap and water and ventilate the area. Put all
wastes in a plastic bag for disposal and seal it tightly. Remove, clean, or dispose
of contaminated clothing.
7. HANDLING AND STORAGE
HANDLING : Avoid contact with eyes, skin and clothing. Avoid prolonged or repeated exposure. Handle
material with suitable protection.
STORAGE : Store away from sunlight in a cool( 2-10 掳C= 35.6-50 掳F ) well-ventilated dry place. Do not
freeze. Keep container tightly closed.
See the package insert for further handling information.
INCOMPATIBLE PRODUCTS : Oxidizers, acids anhydrides, halgens, aluminum, water-reactive materials(alkali metals etc.)
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
ENGINEERING MEASURES : Use exhaust ventilation to keep airborne concentrations below exposure limits. Use only with
adequate ventilation.
VENTILATION : Local Exhaust ; Necessary, Mechanical(General) ; Recommended
CONTROL PARAMETER :
(6); OSHA Final Limits : TWA= 400ppm, 980mg/m3
ACGIH TLV(s) : TWA= 400ppm, 983mg/m3; STEL= 500ppm,1230mg/m3
(1)-(5),(7); OSHA Final Limits : None established
ACGIH TLV(s) : None established
PERSONAL PROTECTION ;
Respiratory protection : NIOSH/MSHA approved respirator
Hand protection : Chemical resistant gloves
Eye protection : Safety glasses(goggles)
Skin protection : Protective clothing
9. PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE : [1]-[4]; Colorless clear liquid
ODOR : [3]; Characteristic odor
[1],[2],[4]; Not available
pH : [1]-[4]; Not available
BOILING POINT : [3]; 83 掳C= 181 掳F (as (4))
[1],[2],[4]; Not available
MELTING POINT : [3]; -90 掳C= -130 掳F (as (4))
[1],[2],[4]; Not available
FLASH POINT : [3]; 11.7 掳C= 53.1 掳F (as (4))
[1],[2],[4]; Not available
AUTOIGNITION TEMPERATURE : [3]; 456 掳C= 853 掳F (as (4))
FLAMMABILITY (solid, gas) : [1]-[4]; -----
DECOMPOSITION TEMPERATURE : [1]-[4]; Not available
EXPLOSIVE LIMITS : [3]; Lower; 2%, Upper; 12% (as (4))
[1],[2],[4]; Not available
VAPOR PRESSURE : [3]; 4.4kPa (20 掳C= 68 掳F) (as (4))
[1],[2],[4]; Not available
SPECIFIC GRAVITY : [1]-[4]; Not available
SOLUBILITY IN ;
WATER : [1]-[4]; Miscible
log Po/w : [1]-[4]; Not available
10. STABILITY AND REACTIVITY
CONDITION TO AVOID : Sunlight, heat, open flames, high temperature, sparks, static electrical
charge, other ignition sources
INCOMPATIBILITY(MATERIAL TO AVOID) : Oxidizers, acids anhydrides, halgens, aluminum, water-reactive
materials(alkali metals etc.)
HAZARDOUS DECOMPOSITION PRODUCTS : Carbon monoxide and nitrogen oxides may be formed.
HAZARDOUS POLYMERIZATION : Will not occur.
11. TOXICOLOGICAL INFORMATION
ACUTE TOXICITY DATA : Not available as the mixture
(5); TDLo(orl,woman): 325mg/kg(PGMJAO 68,116,1992)
LD50(orl,rat): 1944mg/kg(USXXXAM #4636513)
LD50(orl,mouse): 338mg/kg(TXAPA9 19,20,1971)
(6); TDLo(orl,man): 14432mg/kg(NEJMAG 277,699,1967)
LDLo(orl,human): 3570mg/kg(34ZIAG -,339,1969)
TDLo(orl,infant): 13gm/kg(AJEMEN 10,542,1992)
LD50(orl,rat): 5045mg/kg(GISAAA 43(1),8,1978)
LC50(ihl,rat): 16000ppm/8H(NPIRI* 1,100,1974)
LD50(skin,rabbit): 12800mg/kg(NPIRI* 1,100,1974)
(7); as 30% Hydrogen peroxide
TDLo(orl,woman): 1200mg/kg(AEMWS3 21,1391,1992)
LD50(skin,rabbit): 3gm/kg(STGNBT -,39,1999)
IRRITATION DATA : Not available as the mixture
(6); Eye; rabbit; 100mg; Severe(AJOPAA 29,1363,1946)
Eye; rabbit; 100mg/24H; Moderate(85JCAE -,191,1986)
Skin; rabbit; 500mg; Mild(NTIS** AD-A106-944)
MUTATION DATA : Not available as the mixture
(5); Mutation in microorganisms; S.typhimurium; 100碌g/disc(JNUDAT 34,183,1992)
Cytogenetic analysis; mouse; liver; 1mmol/L(TXAPA9 111,242,1991)
(6); Cytogenetic analysis; rat-inhalation; 1030碌g/m3/16W-I(GTPZAB 25(7),33,1981)
(7); as 30% Hydrogen peroxide
Cytogenetic analysis; hamster; ovary; 60?mol/L(EMMUEG 26,248,1995)
REPRODUCTIVE EFFECTS DATA : Not available as the mixture
(5); TDLo(orl,woman): 1300mg/kg(31-32 W preg)(BJOGAS 96,491,1989)
TDLo(orl,rat): 500mg/kg(3 D preg)(ZYDXDM 27,49,1998)
(6); TDLo(orl,rat): 8gm/kg(6-15 D preg)(RTOPDW 23,183,1996)
TCLo(ihl,rat): 3500ppm/7H(1-19 D preg)(FCTOD7 26,247,1988)
TUMORIGENIC DATA : Not available as the mixture
(5); TDLo(orl,rat): 164gm/kg/78W-C(ACPADQ 93,367,1985)
(7); as 30% Hydrogen peroxide
TDLo(orl,mouse): 662gm/kg/2Y-C(HIUN**)
ADDITIONAL INFORMATION ;
NTP : Not listed
IARC : (5),(7); Not Classifiable as to Carcinogenicity to Humans (Group 3)
(6); Not Classifiable as to Carcinogenicity to Humans (Group 3)
OSHA : Not listed
ACGIH : (7); Animal Carcinogen (A3)
(5); EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
(6); EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; N crossa-aneuploidy
(7); as Hydrogen peroxide 30%
EPA GENETOX PROGRAM 1988, Positive: N crossa-reversion; E coli pol A without S9
12. ECOLOGICAL INFORMATION
BIODEGRADABILITY : (6); This material is biodegradable.
BIOACCUMULATION POTENTIAL : Not available
AQUATIC TOXICITY : (6); LC50(guppies): 7060ppm/7days
LC50(fathead minnow): 11830mg/L/1hr
OTHER INFORMATION : (6),(7); WGK; 1
13. DISPOSAL CONSIDERATION
[1],[2],[4]; Take up the material with combustible absorbents and burn in small portion in a chemical incinerator equipped with
an afterburner and scrubber in accordance with all applicable regulations. Any disposal practice must be in
compliance with country, local, state, and federal laws and regulations ( contact country, local or state
environmental agency for specific rules ).
[3]; Burn in a chemical incinerator equipped with an afterburner and scrubber in accordance with all applicable
regulations. Any disposal practice must be in compliance with country, local, state, and federal laws and regulations
( contact country, local or state environmental agency for specific rules ).
14. TRANSPORT INFORMATION
[1],[2],[4]; IATA : Not Restricted.
DOT(Department of Transportation) : Not a Hazardous Material for DOT shipping.
[3]; IATA :
PROPER SHIPPING NAME : Isopropanol
CLASS or DIVISION : Flammable liquid.(Class 3)
UN or ID No. : UN1219
DOT(Department of Transportation) :
PROPER SHIPPING NAME : Isopropanol
HAZARD CLASS : Flammable liquid (Class 3)
IDENTIFICATION NUMBER : UN1219
15. REGULATORY INFORMATION
US REGULATIONS ;
(1)-(4); EPA : CERCLA RQ= Not listed
EPCRA TPQ= Not listed
OSHA : TQ= Not listed
(5); NTP Test. Prog.
EPA : CERCLA RQ= Not listed
EPCRA TPQ= Not listed
OSHA : TQ= Not listed
(6); TSCA/4(a) Final Test Rules/Cons. Agree., TSCA/12(b) Expor. Notif., TSCA CHIPs,, CAA/111 Volat. Org. Comp.,
NIOSH Recommend. Subst., DOT Haz. Mat., Mass. Subst. List , New Jers. RTK Haz. Subst. List , Penn. Haz.
Subst. List , Canad. WHMIS IDL 1% conc.
EPA : CERCLA RQ= Not listed
EPCRA TPQ= Not listed
EPCRA SECTION 313 de minimis concentration is 1.0%.
FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
OSHA : TQ= Not listed
(7); NIOSH Recommend. Subst., DOT Haz. Mat., Mass. Subst. List , New Jers. RTK Haz. Subst. List , Penn. Haz.
Subst. List , Canad. WHMIS IDL 1% conc.
EPA : CERCLA RQ= Not listed
EPCRA TPQ= Not listed
OSHA : TQ= Not listed
TSCA : Use of this product must be restricted to research or analysis for the development of a product in accordance with
the Act.
EU REGULATIONS ;
[3]; SYMBOL : F, Xi
R-phrases : 11-36-67
Highly flammable.
Irritating to eyes.
Vapours may cause drowsiness and dizziness.
S-phrases : 7-16-24/25-26
Keep container tightly closed.
Keep away from sources of ignition- No smoking.
Avoid contact with skin and eyes.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
[1],[2],[4]; SYMBOL : -----
R-phrases : -----
S-phrases : -----
EC index No. : (6); 603-117-00-0
(7); 008-003-00-9
(1)-(5); Not listed
16. OTHER INFORMATION
No specific notes
The above information is believed to be correct to be the best of our knowledge and
information but does not purport to be all inclusive and shall be used only as a guide.
This product is intended to be used by expert persons having chemical knowledge and skill,
at their own discretion and risk and Wako shall not be held liable for any damage
resulting from handling or from contact with the above material.
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