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MSDS Ref. No: QS-MSD-180
Version: US/Canada
Date Approved: 12/31/06
Revision No: 10
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Lithium Diisopropylamide in THF/Heptane
PRODUCT NAME:
Organometallic Amide
CHEMICAL FAMILY:
LiN[CH(CH3)2]2
MOLECULAR FORMULA:
LDA 9505 and LDA
SYNONYM(s):
Industrial Manufacturing
GENERAL USE:
MANUFACTURER Emergency Telephone Numbers:
FMC CORPORATION CHEMTREC (800) 424-9300
Lithium Division Emergency Phone (704) 629-5361 (Plant) Call
P.O. Box 795 Collect 24 Hr/Day
Bessemer City, NC 28016-0795 Emergency Phone (303) 595-9048 (Medical)
General Information: (704) 868-5300 Call Collect
2. COMPOSITION / INFORMATION ON INGREDIENTS
Chemical Name CAS # Wt.%
Lithium Diisopropylamide (LDA) 4111-54-0 20 - 30
Tetrahydrofuran 109-99-9 20 - 30
Diisopropylamine 108-18-9 <4
Ethylbenzene 100-41-4 10 - 15
Heptanes * 64742-49-0 25 - 30
Organo-magnesium (stabilizer) not available 0 - 0.9
N-Butane 106-97-8 <3
Styrene 100-42-5 <1
* Contains predominately C7 isomers with remaining constituents C8 isomers. Contains n-heptane CAS# 142-82-5,
and methylcyclohexane CAS# 108-87-2.
3. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable liquid. Water reactive. In case of fire do not use water or
IMMEDIATE CONCERNS:
carbon dioxide. Yellow to reddish liquid with pungent odor.
Corrosive to the eyes (may cause blindness), skin, mucous
POTENTIAL HEALTH EFFECTS:
membranes and upper respiratory tract. Inhalation of vapors may
cause dizziness, nausea, anesthesia, numbness, motor weakness
in fingers and toes, incoordination, and headache. If ingested,
may produce a lung aspiration hazard.
COMMENTS:
(See Section 11, Toxicological Information)
4. FIRST AID MEASURES
Immediately flush with water for at least 15 minutes, lifting the
EYES:
upper and lower eyelids intermittently. See a medical doctor or
ophthalmologist immediately.
Quickly wipe off as much as possible, then immediately flush with
SKIN:
plenty of water while removing contaminated clothing and/or shoes.
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MSDS Ref. No: QS-MSD-180
Version: US/Canada
Date Approved: 12/31/06
Revision No: 10
Thoroughly wash with soap and water. Obtain immediate medical
attention. Contact a medical doctor if necessary.
Quickly wipe material from the mouth and rinse mouth with water.
INGESTION:
Do not induce vomiting. Never give anything by mouth to an
unconscious person. See a medical doctor immediately.
Remove to fresh air. If breathing discomfort occurs and persists,
INHALATION:
see a medical doctor. If breathing has stopped, give artificial
respiration and see a medical doctor immediately.
NOTES TO MEDICAL DOCTOR:
This product is formulated with several compounds having specific toxicities. See ingredients - Section 2, and Acute
and Chronic Effects. Product is corrosive to the eyes, skin, nose and throat. Due to the potential for severe
esophageal injury and the low oral toxicity, emesis should be avoided. Consideration may be given to gastric lavage.
Observation for effects on the central and peripheral nervous systems, as well as lung function, is suggested after
larger exposures. Treatment is otherwise symptomatic and supportive.
5. FIRE FIGHTING MEASURES
Tetrahydrofuran: Upper: 11.8% Lower: 2%
FLAMMABLE LIMITS:
Heptane: Upper: 6.7% Lower: 1.05%
Ethylbenzene: Upper: 6.7% Lower: 0.8%
Flammable liquid. Reacts vigorously with water to give off flammable
GENERAL HAZARD:
fumes and corrosive dust.
DO NOT USE WATER OR CARBON DIOXIDE. Use dry chemical.
EXTINGUISHING MEDIA:
Lithium hydroxide, carbon dioxide, carbon monoxide.
HAZARDOUS COMBUSTION PRODUCTS:
Wear full protective clothing and self-contained breathing apparatus
FIRE FIGHTING PROCEDURES:
(SCBA) approved for fire fighting. This is necessary to protect against
the hazards of heat, products of combustion and oxygen deficiency.
Do not breathe smoke, gases or vapors generated.
Not available for product. 432 潞C (ethylbenzene); 321 潞C (THF)
AUTOIGNITION TEMPERATURE:
Water reactivity and volatility of solvents.
PROPERTIES CONTRIBUTING TO
FLAMMABILITY:
2潞C
FLASH POINT:
Yes
SENSITIVITY TO STATIC DISCHARGE:
None
SENSITIVITY TO IMPACT:
COMMENTS:
(See Section 10, Stability and Reactivity)
6. ACCIDENTAL RELEASE MEASURES
Remove all sources of ignition. Do not use water in the initial phases
RELEASE NOTES:
of clean up. Contain spill with absorbant. Transfer to approved
transport container and clean up spillage with an absorbant. Dispose
of waste according to local and Federal laws and regulations.
Before cleanup measures begin, review the entire MSDS with
particular attention to Section 3, Emergency Overview and Potential
Health Effects; and Section 8, Recommended Personal Protective
Equipment.
7. HANDLING AND STORAGE
Use in a closed system under argon or nitrogen. Do not get in eyes,
HANDLING:
on skin or clothing. Do not breathe vapors or mist.
Store in a cool place. Keep container closed. Keep away from
STORAGE:
sources of ignition, water, air, acids and oxidizing agents.
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MSDS Ref. No: QS-MSD-180
Version: US/Canada
Date Approved: 12/31/06
Revision No: 10
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE LIMITS
Chemical Name TWA STEL/Ceiling PEL STEL/Ceiling
(ACGIH) (ACGIH) (OSHA) (OSHA)
Tetrahydrofuran 200 ppm 250 ppm 200 ppm
Diisopropylamine 5 ppm 5 ppm
Ethylbenzene 100 ppm 125 ppm 100 ppm
n-Heptane 400 ppm 500 ppm 500 ppm
methylcyclohexane 400 ppm 500 ppm
Styrene 20 ppm 40 ppm 100 ppm 200 ppm
butane (aliphatic hydrocarbon 1000 ppm
gases: C1 鈥? C4)
IDLH: Ethylbenzene: 800 ppm
Tetrahydrofuran:
Styrene: 700 ppm
Diisopropylamine: 200 ppm
ENGINEERING CONTROLS:
Use in closed system under argon or nitrogen. If personal contact can occur, use local exhaust ventilation (explosion-
proof), to keep airborne concentrations below exposure limits.
PERSONAL PROTECTIVE EQUIPMENT
Chemical splash goggles with a face shield.
Eyes And Face:
When engineering controls are not adequate, wear a NIOSH/MSHA
Respiratory:
respirator approved for protection against organic vapors and mists.
Rubber gloves and rubber clothing
Protective Clothing:
Quick-drench eyewash and safety shower.
Work Hygienic Practices:
9. PHYSICAL AND CHEMICAL PROPERTIES
Pungent
ODOR:
Liquid, clear yellow to reddish color
APPEARANCE:
Reacts with water to form mixture with pH 13-14
pH:
70 to 80
PERCENT VOLATILE:
7 mm Hg @ 20 潞C (ethylbenzene); 162.1 mm Hg @ 20 C掳 (THF); 40
VAPOR PRESSURE:
mmHg @ 22.3潞C (heptane)
(air = 1) 3.66 (ethylbenzene); 2.49 (THF)
VAPOR DENSITY:
Appr. 60潞C to 136潞C; 136 潞C (ethylbenzene); 66 潞C (THF); 98 C掳
BOILING POINT:
(heptane)
0潞C (<32潞F)
MELTING POINT:
Exothermic reaction to form basic lithium and magnesium hydroxides,
SOLUBILITY IN WATER:
and diisopropylamine
0.84 (ethylbenzene); 8 (THF)
EVAPORATION RATE(Butyl Acetate = 1):
0.6 to 0.9 g/ml
SPECIFIC GRAVITY:
107.13
MOLECULAR WEIGHT:
Not applicable for product. Log P(oct) = 3.15 (ethylbenzene); 0.46
COEFF. OIL/WATER:
(THF)
Not available
ODOR THRESHOLD:
Tetrahydrofuran: Upper: 11.8% Lower: 2%
FLAMMABLE LIMITS:
Heptane: Upper: 6.7% Lower: 1.05%
Ethylbenzene: Upper: 6.7% Lower: 0.8%
2潞C
FLASH POINT:
Not available for product. 432 潞C (ethylbenzene); 321 潞C (THF)
AUTOIGNITION TEMPERATURE:
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MSDS Ref. No: QS-MSD-180
Version: US/Canada
Date Approved: 12/31/06
Revision No: 10
Not explosive
EXPLOSIVE PROPERTIES:
Not an oxidizer
OXIDIZING PROPERTIES:
10. STABILITY AND REACTIVITY
Heat, water and temperatures above 40潞C (104潞F).
CONDITIONS TO AVOID:
Stable at room temperature.
STABILITY:
Does not polymerize
POLYMERIZATION:
Lithium oxide, hydroxide and hydride, hydride and amines
HAZARDOUS DECOMPOSITION
PRODUCTS:
Heat, fire, air, water, acids and oxidizing chemicals
INCOMPATIBLE MATERIALS:
11. TOXICOLOGICAL INFORMATION
No data available for the product.
Eye Contact:
Corrosive
Corrosive, PG II, Corrositex In-Vitro Skin Corrosion [FMC study I99-
Skin Contact:
2304]
No data available for the product.
Skin Absorption:
Lithium Diisopropylamide: Corrosive
Diisoproylamine: Dermal LD50 >10 gm/kg (rabbit) [[RTECS 2006]
Ethylbenzene: Dermal LD50 17800 uL/kg (rabbit) [[RTECS 2006]
No data available for the product.
Ingestion:
Lithium Diisopropylamide: Corrosive
THF: Oral LD50 = 1650 mg/kg (rat) [RTECS 2006]
Diisoproylamine: Oral LD50 = 770 mg/kg (rat) [RTECS 2006]
Ethylbenzene: Oral LD50 = 3500 mg/kg (rat) [RTECS 2006]
Styrene: Oral LD50 = 2650 mg/kg (rat) [RTECS 2006]
No data available for the product.
Inhalation:
Lithium Diisopropylamide: Corrosive
THF: LC50 = 21,000 ppm , 3 hr., (rat) [RTECS 2006]
Diisoproylamine: Inhalation LC50 = 4800 mg/m3/2H [RTECS 2006]
(rat)
Ethylbenzene Inhalation LC50 = 4000 ppm/4hr (rat) Smyth, et al. AIH
Assn J. 1962
n-Heptane: Inhalation LC50 103 gm/m3/4H (rat) [RTECS 2006]
Styrene: Inhalation LC50 = 11800 mg/m3/4H (rat) [RTECS 2006]
Butane: LC50 658 gm/m3/4H (rat) [RTECS 2005]
Acute Effects From Overexposure:
This product reacts with water producing flammable gases and corrosive dusts. It is corrosive to the eyes (may cause
blindness), skin, respiratory and gastrointestinal tracts.
Inhalation of vapors may cause dizziness, nausea, anesthesia, numbness, burning sensation and motor weakness in
fingers and toes, incoordination, and headache. Low viscosity material--if swallowed may enter the lungs and cause
lung damage.
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MSDS Ref. No: QS-MSD-180
Version: US/Canada
Date Approved: 12/31/06
Revision No: 10
Chronic Effects From Overexposure:
No data available for the product.
Ethylbenzene: Inhalation of high concentrations of ethylbenzene caused kidney effects in rats and mice. Available
study results do not indicate that ethylbenzene is mutagenic Available study results do not indicate that ethylbenzene
causes developmental toxicity at doses that are not also toxic to the mothers. Studies indicate that ethylbenzene is
not sensitizing.
Tetrahydrofuran: Repeated or prolonged exposure may cause signs of central nervous system depression and
respiratory irritation.
Repeated or prolonged skin contact with the solvents may cause dermatitis and skin sensitization. Chronic exposure
to aromatic hydrocarbons may cause headaches, dizziness, loss of sensations or feelings (such as numbness), liver
and kidney damage.
No data available for the product.
Sensitization:
Ethylbenzene: Studies indicate that ethylbenzene is not sensitizing.
EH40: Not listed.
Carcinogenicity:
IARC: Ethylbenzene and styrene are listed as Group 2B, possibly
carcinogenic to humans.
NTP: Tetrahydrofuran is listed as a substance that is reasonably be
anticipated to be a carcinogen.
OSHA: Ethylbenzene and styrene are considered carcinogens under
OSHA (29 CFR 1910.1200AppA).
ACGIH: Ethylbenzene is listed as Category A3, confirmed animal
carcinogen with unknown relevance to humans. Styrene is listed as
Category A4, not classifiable as a human carcinogen.
Tetrahydrofuran is listed as Category A3, a confirmed animal
carcinogen with unknown relevance to humans.
No data available for the product.
Mutagenicity:
Ethylbenzene: Available study results do not indicate that
ethylbenzene is mutagenic
THF: THF gave negative results in bacterial mutagenicity tests with
and without metabolic activation.
Butane: Negative results were reported on short-term tests using
bacteria.
No data available for the product.
Reproductive Toxicity:
Ethylbenzene: Available study results do not indicate that
ethylbenzene causes developmental toxicity at doses that are not
also toxic to the mothers.
THF: One animal study suggests that THF does not cause effects at
doses which are not maternally toxic.
12. ECOLOGICAL INFORMATION
Ecotoxicological Information:
Environmental testing of the product has not been carried out.
Diisopropylamine:
LC50 = 40 to 60 mg/L (creek chub) [Handbook Env. Data on Org. Chem., 4th Ed]
THF:
48 hr. LC50 = 2820; 2930 mg/l (orfe) [Handbook Env. Data on Org. Chem., 4th Ed]
96 hr. LC50 = 2160 mg/l (Fathead minnow) [Handbook of Env. Data on Org. Chem., 4th Ed]
Ethylbenzene:
Various freshwater fish 96 hr. LC50 =32.-97 mg/L)
Daphnia 24 hr. IC50 = 2.2 mg/l [Handbook Env. Data on Org. Chem., 4th Ed]
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MSDS Ref. No: QS-MSD-180
Version: US/Canada
Date Approved: 12/31/06
Revision No: 10
n-heptane:
24h LC50 = 4 mg/L (goldfish)
24-96h LC50 = 4924 mg/L (mosquito fish)
48h EC50 = 1.5 mg/L (daphnia magna) [Env. Data on Org. Chem., 4th Ed]
Chemical Fate Information:
Lithium diisopropylamide reacts violently with water, releasing diisopropylamine and lithium hydroxide. All organic
ingredients of this product are expected to volatize from both soil and water. All have a tendency to biodegrade. All
are not expected to bioaccumulate. Diisopropylamine, ethylbenzene and heptane are expected to adsorb to soils.
Ethylbenzene: Ethylbenzene is expected to volatilize and biodegrade in both soil and water. It is not expected to
undergo hydrolysis or photolysis. It may adsorb moderately to soil, and may leach into groundwater. It is not expected
to bioconcentrate.
Tetrahydrofuran: THF is expected to volatilize from both water and soil and leach into groundwater. It will not
photodegrade or adsorb to sediment. Limited evidence suggests it may biodegrade. Based on a relatively low Kow
(0.47), it is not expected to bioconcentrate.
Heptane: n-Heptane will readily volatize from both soil and water. If released to water the product will float. The
product is insoluble in water. If released to soil it will evaporate at a rapid rate. The product is poorly absorbed onto
soils or sediments. The product is expected to be readily biodegradable. Photochemical degradation in air will
proceed at a moderate rate. BOD5 = 55% of ThOD. Heptane is not expected to bioaccumulate.
13. DISPOSAL CONSIDERATIONS
Dispose of waste according to local and Federal laws and regulations.
DISPOSAL METHOD:
14. TRANSPORT INFORMATION
Flammable liquid, corrosive, N.O.S. (Lithium diisopropylamide in
PROPER SHIPPING NAME:
tetrahydrofuran/heptane)
3, Flammable liquid, (8, Corrosive)
CLASSIFICATION:
Flammable, Corrosive
LABELS:
UN2924
UN NUMBER:
II
PACKING GROUP:
2942.00.0000
CUSTOM TARIFF NO:
No
MARINE POLLUTANT:
Not designated Poison Inhalation Hazard by US DOT.
PIH:
15. REGULATORY INFORMATION
UNITED STATES Immediate (acute) health hazard, delayed (chronic) health
SECTION 311 HAZARD CATEGORY (40 CFR 370): hazard, fire hazard, reactive
This product contains ethylbenzene and styrene which are
SECTION 313 REPORTABLE INGREDIENTS (40
subject to the reporting requirements of Section 313 of the
CFR 372):
Emergency Planning and Community Right-To-Know Act of
1986.
This information must be included in all MSDS's that are
copied and distributed for this material.
SECTION 302 EXTREMELY HAZARDOUS
SUBSTANCES (40 CFR 355): Not listed
CERCLA HAZARDOUS SUBSTANCE (40 CFR Tetrahydrofuran, ethylbenzene and styrene are listed. The
302.4): reportable quantities are 1000 pounds for each chemical.
Page 7 of 7
MSDS Ref. No: QS-MSD-180
Version: US/Canada
Date Approved: 12/31/06
Revision No: 10
This product is subject to TSCA 12(b) export notification
TSCA SEC 12B EXPORT NOTIFICATION:
requirements due to the presence of tetrahydrofuran and
heptane.
TSCA INVENTORY STATUS (40 CFR 710): Listed
Product Identification No.: 2924
CANADA
Hazard Classification: Class B, Division 6 (Reactive
WHMIS:
Flammable Materials)
Class E, (Corrosive)
Class D, Division 2B (Toxic Material with Chronic Effects)
Ingredient Disclosure List: Diisopropylamine,
tetrahydrofuran, heptane, ethylbenzene, styrene and butane
are listed.
16. OTHER INFORMATION
REVISION SUMMARY: Revision # 10: Regular review completed. Sections 2, 5, 8, 9, 11, 12, 14 and 15 revised.
NFPA RATING HEALTH: 3
FLAMMABILITY: 3
REACTIVITY: 2
SPECIAL: W
This MSDS has been prepared to meet U. S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and
Canada's Workplace Hazardous Materials Information System (WHMIS) requirements.
type 2c
Copyright 2006. FMC Corporation, Lithium Division. All Rights Reserved. FMC Lithium and the FMC Lithium logo
are trademarks of FMC Corporation.
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