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Material Safety Data Sheet
1,4-Phenylene diisothiocyanate
1: Chemical Product and Company Identification
Product Name: 1,4-Phenylene diisothiocyanate
Contact information:
Catalog Code: 507047
bioWORLD
CAS#: 4044-65-9
4150 Tuller Rd
Suite 228, Dublin, OH 43017, USA
RTECS: NX9150000
For information, call: 614-792-8680
TSCA: TSCA 8(b) inventory : 1, 4-Phenylene diisothiocyanate
Fax Number: 614-792-8685
Order Online:www.bio-world.com
CI#: Not available.
E-mail : save@bio-world.com
Synonym: Biscomate; Bitoscanate; 1,4-
Diisothiocyanatobenzene; Isothiocyanic acid p-phenylene ester;
In case of a chemical emergency, contact local
Phenylene-1,4-diisothiocyanate; Phenylene thiocyanate; p-
hospital.
Phenylene diisothiocyanate
For non-emergency assistance,call: 1-800-860-9729
Chemical Name: 1, 4-Phenylene diisothiocyanate
Chemical Formula: C8H4N2S2
2: Composition and Information on Ingredients
Composition:
Name CAS# % by Weight
1, 4-Phenylene diisothiocyanate 4044-65-9 -
Toxicological Data on Ingredients:
LD50 (Intraperitoneal, Rat): 21 mg/kg
LD50 (Oral, Mouse): 230 mg/kg
LD50 (Intraperitoneal, Mouse): 21 mg/kg
3: Hazards Identification
Potential Acute Health Effects: Toxic (USA) Harmful (EU). Harmful if swallowed. Irritating to eyes, respiratory system
and skin. May cause sensitization by inhalation. Lachrymator.
Potential Chronic Health Effects:
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CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
4: First Aid Measures
Eye Contact: In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate
flushing by separating the eyelids with fingers. Call a physician.
Skin Contact: In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated
clothing and shoes. Call a physician.
Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek
medical attention.
Inhalation: If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
Serious Inhalation: Not available.
Ingestion: If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Serious Ingestion: Not available.
5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Product of Combustion: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides, Hydrogen cyanide
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Dry chemical powder.
LARGE FIRE: Carbon dioxide, dry chemical powder, or appropriate foam.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
6: Accidental Release Measures
Small Spill: Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site
after material pickup is complete.
Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
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water on the contaminated surface and allow to evacuate through the sanitary system.
7: Handling and Storage
Precautions: Do not breathe dust. Do not get in eyes, on skin, on clothing.
Storage: Keep tightly closed. Store in a cool dry place. Store under nitrogen.
8: Exposure Controls/Personal Protection
Engineering Controls: Safety shower and eye bath. Use only in a chemical fume hood.
Personal Protection: Respiratory : Government approved respirator.
Hand: Chemical resistant gloves.
Eye: Safety glasses.
Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Boots. Dust respirator. Gloves.
Exposure Limits: Not available.
9: Physical and Chemical Properties
Physical State and Appearance: Solid.
Odor: Not available.
Taste: Not available.
Molecular Weight: 192.26 g/mole
Color: Faintly beige
pH(1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: 129 潞 C
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapour Pressure: Not available.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility: Not available.
10: Stability and Reactivity Data
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Stability: Stable.
Instability Temperature: Not available.
Conditions of Instability: May decompose on exposure to moist air or water.
Incompatibility with various substances: Strong oxidizing agents, Strong acids, Strong bases.
Corrosivity: Not available.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
11:Toxicological Information
Routes of Entry: Skin contact. Eye contact. Ingestion. Inhalation.
Toxicity to Animals:
LD50 (Intraperitoneal, Rat): 21 mg/kg
LD50 (Oral, Mouse): 230 mg/kg
LD50 (Intraperitoneal, Mouse): 21 mg/kg
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans: Eye contact: Lachrymator. Causes eye irritation.
Skin contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Ingestion : Harmful if swallowed.
Inhalation : May be harmful if inhaled. Material is irritating to mucous membranes and upper respiratory tract.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.;
12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Product of Biodegradation: Not available.
Toxicity of the Products of Biodegradation: Not available.
Special Remarks on the Products of Biodegradation: Not available.
13: Disposal Considerations
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Waste Disposal: Contact a licensed professional waste disposal service to dispose of this material. Observe all federal,
state, and local environmental regulations.
14: Transport Information
DOT Classification: Class: 6.1
Identification: UN #: 2206
Packing Group: III
Special Provisions for Transport: Not available.
15: Other Regulatory Information
Federal and State Regulations: TSCA 8(b) inventory : 1, 4-Phenylene diisothiocyanate
Other Regulations: EU Classification:
Symbol of Danger: Xn; Indication of Danger: Harmful
Risk Phrases:
R: 22-36/37/38-42; Harmful if swallowed. Irritating to eyes, respiratory system and skin. May cause sensitization by
inhalation. Safety Phrase:
S: 22-26-36/37; Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical
advice. Wear suitable protective clothing and gloves.
Other Classifications:
WHMIS(Canada): Not available.
DSCL(EEC): Not available.
HMIS(U.S.A):
Health Hazard: 3
Fire Hazard: 0
Reactivity: 1
Personal Protection:
National Fire Protection Association (U.S.A):
Health: 3
Flammability: 0
Reactivity: 1
Specific hazard:
Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Safety goggles.
16: Other Information
References: 1.) Laursen, R.A., et al. (1972) FEBS Lett. 21, 67.
Other Special Considerations: Not available.
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Created: 05/01/2007 4:31:35 PM
Last Updated: 06/01/2007 2:28:47 PM
Disclaimer
This product is offered by bioWORLD for research, laboratory or further manufacturing use. Not for human use or
consumption.
The information above is believed to be accurate and represents the best information currently available to us. However,we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we
assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the
information for their particular purposes.In no event shall Bio-World.com be liable for any claims, losses, or damages of any
third party or for lost profits or any special, indirect,incidental,consequential or exemplary damages, howsoever arising,
even if Bio-World.com has been advised of the possibility of such damages.
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