Valid 11/1999 - 01/2000
Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765
MATERIAL SAFETY DATA SHEET
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: L3876
NAME: LITHIUM CARBONATE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 554-13-2
MF: CLI2O3
EC NO: 209-062-5
SYNONYMS
CAMCOLIT * CANDAMIDE * CARBOLITH * CARBONIC ACID, DILITHIUM SALT *
CARBONIC ACID LITHIUM SALT * CEGLUTION * CP-15467-61 * DILITHIUM
CARBONATE * ESKALITH * HYPNOREX * LIMAS * LISKONUM * LITHANE *
LITHICARB * LITHINATE * LITHIUM CARBONATE * LITHOBID * LITHONATE *
LITHOTABS * NSC-16895 * PLENUR * PRIADEL * QUILONUM RETARD *
TERALITHE (FRENCH) *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC
MAY CAUSE HARM TO THE UNBORN CHILD.
MAY CAUSE HARM TO BREASTFED BABIES.
POSSIBLE RISK OF IMPAIRED FERTILITY.
HARMFUL IF SWALLOWED.
IRRITATING TO EYES.
TARGET ORGAN(S):
CENTRAL NERVOUS SYSTEM
KIDNEYS
AVOID EXPOSURE - OBTAIN SPECIAL INSTRUCTIONS BEFORE USE.
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
COVER WITH DRY LIME OR SODA ASH, PICK UP, KEEP IN A CLOSED CONTAINER
AND HOLD FOR WASTE DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
DISCARD CONTAMINATED SHOES.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
SOLID.
PHYSICAL PROPERTIES
MELTING POINT: 618 C
SPECIFIC GRAVITY: 2.11
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
STRONG ACIDS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
CARBON MONOXIDE, CARBON DIOXIDE
LITHIUM OXIDES
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
EXPOSURE CAN CAUSE:
NAUSEA, VOMITING, DIARRHEA
ANOREXIA
LARGE DOSES OF LITHIUM ION HAVE CAUSED DIZZINESS AND PROSTRATION, AND
CAN CAUSE KIDNEY DAMAGE IF SODIUM INTAKE IS LIMITED. DEHYDRATION,
WEIGHT LOSS, DERMATOLOGICAL EFFECTS AND THYROID DISTURBANCES HAVE BEEN
REPORTED. CENTRAL NERVOUS SYSTEM EFFECTS THAT INCLUDE SLURRED SPEECH,
BLURRED VISION, SENSORY LOSS, ATAXIA AND CONVULSIONS MAY OCCUR.
DIARRHEA, VOMITING AND NEUROMUSCULAR EFFECTS SUCH AS TREMOR, CLONUS
AND HYPERACTIVE REFLEXES MAY OCCUR AS A RESULT OF REPEATED EXPOSURE TO
LITHIUM ION.
CYANOSIS AND T-WAVE INVERSION HAVE OCCURRED IN THE BREAST-FED INFANTS
OF WOMEN RECEIVING LITHIUM CARBONATE THERAPY.
MAY CAUSE SKIN IRRITATION.
CAUSES EYE IRRITATION.
MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
CHRONIC EFFECTS
MAY CAUSE CONGENITAL MALFORMATION IN THE FETUS.
MAY CAUSE REPRODUCTIVE DISORDERS.
TARGET ORGAN(S):
CENTRAL NERVOUS SYSTEM
KIDNEYS
CARDIOVASCULAR SYSTEM
THYROID
RTECS #: OJ5800000
LITHIUM CARBONATE (2:1)
TOXICITY DATA
ORL-RAT LD50:525 MG/KG KSRNAM 7,1273,1973
IPR-RAT LD50:156 MG/KG KSRNAM 7,1273,1973
SCU-RAT LD50:434 MG/KG KSRNAM 7,1273,1973
IVN-RAT LD50:241 MG/KG KSRNAM 7,1273,1973
ORL-MUS LD50:531 MG/KG RPTOAN 33,266,1970
IPR-MUS LD50:236 MG/KG KSRNAM 7,1273,1973
SCU-MUS LD50:413 MG/KG RPTOAN 33,266,1970
IVN-MUS LD50:497 MG/KG KSRNAM 7,1273,1973
ORL-DOG LD50:500 MG/KG 27ZQAG -,436,1972
TARGET ORGAN DATA
SENSE ORGANS AND SPECIAL SENSES (LACRIMATION)
BEHAVIORAL (SLEEP)
BEHAVIORAL (ALTERED SLEEP TIME)
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (HALLUCINATIONS, DISTORTED PERCEPTIONS)
BEHAVIORAL (TOXIC PSYCHOSIS)
BEHAVIORAL (EXCITEMENT)
BEHAVIORAL (ATAXIA)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
GASTROINTESTINAL (HYPERMOTILITY, DIARRHEA)
GASTROINTESTINAL (NAUSEA OR VOMITING)
SKIN AND APPENDAGES (AFTER SYSTEMIC EXPOSURE: DERMATITIS, ALLERGIC)
SKIN AND APPENDAGES (AFTER SYSTEMIC EXPOSURE: DERMATITIS, OTHER)
SKIN AND APPENDAGES (HAIR)
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (LITTER SIZE)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
EFFECTS ON EMBRYO OR FETUS (FETAL DEATH)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CRANIOFACIAL)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
EFFECTS ON NEWBORN (LIVE BIRTH INDEX)
EFFECTS ON NEWBORN (SEX RATIO)
EFFECTS ON NEWBORN (OTHER NEONATAL MEASURES OR EFFECTS)
EFFECTS ON NEWBORN (GROWTH STATISTICS)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
THIS MATERIAL.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
TOXIC
R 61
MAY CAUSE HARM TO THE UNBORN CHILD.
R 64
MAY CAUSE HARM TO BREASTFED BABIES.
R 62
POSSIBLE RISK OF IMPAIRED FERTILITY.
R 22
HARMFUL IF SWALLOWED.
R 36
IRRITATING TO EYES.
S 53
AVOID EXPOSURE - OBTAIN SPECIAL INSTRUCTIONS BEFORE USE.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 36/37/39
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
S 22
DO NOT BREATHE DUST.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
NOHS 1974: HZD 84414; NIS 8; TNF 1035; NOS 10; TNE 6333
NOES 1983: HZD X6906; NIS 1; TNF 3; NOS 1; TNE 198; TFE 151
NOES 1983: HZD 84414; NIS 17; TNF 2182; NOS 31; TNE 39147; TFE 17568
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
U.S. INFORMATION
THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS.
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE DEVELOPMENTAL TOXICITY.
CALIFORNIA PROPOSITION 65:
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1998 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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