MATERIAL SAFETY DATA SHEET
Product Name: Epinephrine Injection, USP
1. CHEMICAL PRODUCT AND COMPANY INFORMATION
Manufacturer Name Hospira, Inc.
275 North Field Drive
And Address
Lake Forest, Illinois 60045
USA
was
Note: Hospira,
formerly Hospital
the Products
Divisionof AbbottLaboratories,
created anindependent
company May 2004.
in
as
EmergencyTelephone CIIEMTREC: 800 424-9300
Hospira, Inc. 224 212-2055
Product Name Epinephrine
Injection,USP
Synonyms None
2. COMPOSITION/INFORMATION ON INGREDIENTS
Ingredient Name Epinephrine
ChemicalFormula ceHr3NO3
Approximate Percent
Component CAS Number RTECS Number
bv Weisht
0.01 5t-43-3 DO2625000
Eninenhrine
7732-r8-s zc0l 10000
Water 99
3. HAZARD INFORMATION
Emergency Overview In clinical use,this materialstimulatesthe sympatheticnervoussystemand the
heart.Targetorgansincludethe nervoussystem,eyes,cardiovascular system
and respiratorysystem.
OccupationalExposure Information on the absorptionof this compoundvia ingestion,
Potential inhalationor skin contactis not available. Avoid liquid aerosolgenerationand
skin contactwith solution.
Signsand Symptoms No signsor symptomsfrom occupationalexposureareknown. Clinical data
suggests following: nervousness, anxiety,palpitations,
the sweating,fearfulness,
restlessness,
tenseness, headache, tremor,dizziness, lightheadness, tachycardia,
nausea, vomiting, respiratorydifficulfy, fever, chills, dilated pupils, blurred
vision, cyanosis,electrocardiogram change,disturbedcardiacrhythm,
hypeftension, metabolicacidosis,and cardiac injury.
Medical Conditions Hypersensitivityto the materialand/or similar materials.Pre-existing
Aggravated by Exposure centralnervoussystem,cardiovascular system,respiratorysystemailments.
,'
Product
Name:Epinephrine
Injectiono
USP
4. FIRST AID MEASURES
Eye Contact: Removefrom sourceof exposure.Flush with copiousamountsof water. If
irritation persistsor signsof toxicity occur, seekmedical attention. Provide
symptomatic/supportive as necessary.
care
Skin Contact: Removefrom sourceof exposure.Flush with copiousamountsof water. If
irritation persistsor signsof toxicity occur, seekmedical attention. Provide
symptomatic/supportive careas necessary.
Inhalation: Removefrom sourceof exposure.If signsof toxicity occur, seekmedical
attention. Provide symptomatic/ supportivecare as necessary.
Ingestion: Removefrom sourceof exposure. If signsof toxicity occur, seekmedical
attention. Provide symptomatic/ supportivecareas necessary.
5. FIRE FIGHTING MEASURES
Flammability: Non-flammable.
Fire & Explosion None
Hazard:
ExtinguishingMedia: Use extinguishingmediaappropriatefor primary causeof fire.
SpecialFire Fighting No specialprovisionsrequiredbeyondnormal fire fighting equipmentsuch
Procedures as flame and chemicalresistantclothing and selfcontained breathingapparatus.
I 6. ACCIDENTALRELEASEMBASURES
water' Disposeof materialsaccordingto the applicablefederal,state,or local
regulations.
| 7. HANpLTNGANp STORAGE
Handling
Storage No specialstoragerequiredfor hazardcontrol. For product protectionstore at
controlledroom temperature l5-30oC(59-86'F).
of
SpecialPrecautions Protectfrom freezing,light and extremeheat.
Guidelin es
Exposurelimits
Component OSHA-PEL ACGIH.TLV Hospira EEL
8 hr TWA:Not 8 hr TWA: : Not 8 hr TWA: I mcg/m3
Epinephrine
Established Established STEL:20mce/m3
Notes: OSHAPEL: US Occupational -
Safety Health
and AdministrationPermissjble
Exposure
Limrr
ACGIHTLV: AmericanConference Govemmental -
of Industrial
Hygienists Threshold
Limit Value.
EEL: Employee
Exposure
Limil
TWA: 8 hour Time Weighted Average.
STEL: 15-minuteShort Term ExposureLimit
Product Name: Epinephrine Injection' USP
Respiratoryprotectionis not neededduring normal product use'
Respiratory Protection
skin is likely, useof imperviousglovesis a
If solution contactwith unprotected
Skin Protection
prudentpractice.
Eye protectionis not requiredduring expectedproduct use conditionsbut may
Eye Protection
be warrantedshoulda splashpotential exist.
Engineeringcontrolsare not neededduring normal product use conditions.
Engineering Controls
PROPERTIES
9. PHYSICAL/CHEMICAL
Clearliquid
Appearance/Physical
State
Not Determined
0dor
that of water(100 oC,212 "F).
Boiling Point Approximately
that of water(0 oC,32 'F).
Freezing Point Approximately
that of water(17.5mm Hg at 20 'C).
Vapor Pressure Approximately
Vapor Density(Air=l) Not Applicable
Evaporation Rate Not Applicable
Bulk Density Not Determined
that of water(1.0)
Specilic Gravity Approximately
Solubility Aqueoussolution
2 . 5- 5 . 4
PII
10. STABILITY AND REACTIVITY
ChemicalStability Stableunder standard and storageconditions.
use
Incompatibilities None
Hazardous Toxic fumesof nitrogenoxides
Decomposition
Products
Hazardous None
Polymerization
11. TOXICOLOGICAL INFORMATION:
- Oral:
Insredient(s) Percent Test Type Units
Value Species
100
Epinephrine LD5O 24-50 mg&g Rats,Mice
LD50 is the dosageproducing 50%o
mortality.
Productcontainsapproximately0.01% Epinephrine.
Acute I oxicity- Dermal:
Ingredient(s) Percent Test Tvpe Units
Value Species
100 LD50(sc)
Epineohrine 62 ms&s Rats
LD50(sc)is thevaluefor skincontact.
Mutagenicity Epinephrinehasproducedmutageniceffects in somebioassays.
Target Organ Effects ln clinical usetargetorganeffects include the nervoussystem,eyes,
cardiovascular systemand respiratorysystem,
Product Name: Epinephrine Injection, USP
12. ECOLOGICAL INFORMATION:
Aquatic Toxicity Not Determined.
13. DISPOSAL CONSIDERATIONS:
Disposal shouldbe performedin accordance
WasteDisposal with the federal,stateor local
regulatoryrequirements.
Container Handling Disposeofcontainer and unusedcontentsin accordance
with federal,state,
and Disposal and local reeulations.
14. TRANSPORTATION INFORMATION
DOT Not Regulated
DOT- USDepartmentTransportation
of Regulations
15.REGULATORY INFORMATION
TSCAStatus Not Regulated
CORCLAStatus Not Regulated
SARA Status Not Regulated
RCRA Status Epinephrine listedin 40CFRPart 261.33(e),
is WasteCodeP042.
PROP65 (Calif.) Not Regulated
Notes: TSCA Toxic SubstanceControlAcl
CERCLA, US EPA law,Comprehensive Environmental
Response,
Compensation, Liability
Act
and
SARA SuperfundAmendmentsand Reauthorization
Act
RCRA US EPA, Resource Conservation RecovervAct
and
Prop65, California
Proposition
65
16. OTHER INFORMATION:
MSDS Coordinator T. Straits MPH, CIH
Date Prepared September 2005
15,
Disclaimer:
The information and recommendations containedhereinare basedupon testsbelievedto be reliable.However,Hospira
doesnot guarantee their accuracyor oompletenessNOR SHALL ANY OF THIS INFORMATION CONSTITUTE A
WARRANry, WI{ETTMR EXPRESSEDOR IMPLIED, AS TO TT{E SAFETY OF T}M GOODS, THE
MERCHANTABILITY OF TF{E GOODS, OR THE FITNESS OF TTM GOODS FOR A PARTICULAR PURPOSE.
Adjustmentto conform to actualconditionsof usagemay be required. Hospira assumes responsibilityfor results
no
obtainedor for incidentalor consequential including lost profits, arising from the use ofthese data. No
damages,
warrantyagainstinfringementof any patent,copyright or trademarkis madeor implied.
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