MSDS: Trichostatin A 2/27/02 5:07 PM
MATERIAL SAFETY DATA SHEET
This form complies with OSHA's Hazard Communication Standard, 29 CFR 1910.1200.
IDENTITY (As Used on Label and List): Trichostatin A
SECTION I - Product Identification
Trichostatin A
Manufacturer Name and Address: Telephone Numbers:
Cayman Chemical Company Cayman Chemical (800)364-9897
1180 E. Ellsworth Rd.
Ann Arbor, MI. 48108 Cayman Chemical (734)971-3335
Date Entered: 08/18/99 Last Revision: 08/18/99 MSDS Printed: 10/01/99
Synonyms:
7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E- heptadienamide
Chemical Family: Inhibitor
Hazard Label:
Molecular Formula: C17H22N2O3 Molecular Weight: 302.40
NFPA Ratings: (0-4) NFPA Specific Hazards
Health: 2
Flammability: 2
Reactivity: 0
SECTION II - Hazardous Ingredients/Identity Information
Trichostatin A
Hazardous Components (Specific Chemical Identity/Common Name) CAS #
Trichostatin A 58880-19-6
CAS # OSHA PEL ACGIH TLV Other Limits Percentage
58880-19-6 100.0
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SECTION III - Physical/Chemical Characteristics
Trichostatin A
Boiling Point: . . . NE or NA
Melting Point: . . . NE or NA
Specific Gravity: . . . NE or NA (Water = 1)
Vapor Pressure: . . . NE or NA (mm Hg)
Vapor Density: . . . NE or NA (Air = 1)
Physical States: . . . [ ] Gas , [ X ] Liquid , [ ] Solid
Evaporation Rate: . . . NE or NA (Butyl Acetate = 1)
Solubility In Water: . . . <15 ug/ml* at 25.0C Other: *PBS pH 7.2, sol. in EtOH, DMSO, & DMF
Percent Volatile: . . . NE or NA
Appearance and Odor:
A clear, colorless solution.
SECTION IV - Fire and Explosion Hazard Data
Trichostatin A
Flash Pt: NE or NA Method Used: See note below
Explosive Limits: LEL: UEL: Autoignition Pt: NE or NA
Extinguishing Media:
Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material.
Special Fire Fighting Procedures:
Note: Flammable as diluted in ethanol.
Unusual Fire and Explosion Hazards:
SECTION V - Reactivity Data
Trichostatin A
Stability: Unstable [ ] Stable [ X ]
Conditions To Avoid - Instability:
This material is stable under normal and aticipated ambient storage and handling conditions, however sunlight and
heat should be avoided.
Incompatibility - Materials To Avoid:
oxidizing materials
Hazardous Decomposition Or Byproducts:
carbon monoxide, nitrogen oxides
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Hazardous Polymerization: May occur [ ] Will not occur [ X ]
Conditions To Avoid - Hazardous Polymerization:
SECTION VI - Health Hazard Data
Trichostatin A
Route(s) of Entry: Inhalation? Yes , Skin? Yes , Eyes? Yes , Ingestion? Yes
Other:
Health Hazards (Acute and Chronic):
If dusting occurs, it may cause eye irritation. Skin contact may cause hypersensitive individuals to experience allergic
reactions and dermatologic reactions such as rash and hives. Prolonged exposure may result in the material being
absorbed through the skin in harmful amounts. Dust is irritating to the eyes, nose, throat, and lungs. It may also cause
headaches and dizziness. Ingestion may cause anorexia, headaches, bellyache, diarrhea, nausea, vomiting, and fever.
Carcinogenicity: NTP? No , IARC Monographs? No , OSHA Regulated? No
Carcinogenicity/Other Information:
Recommended Exposure Limits:
LD 50/LC 50:
Signs and Symptoms Of Exposure:
Irritating to the skin, eyes, nose, throat, and respiratory tract.
Medical Conditions Generally Aggravated By Exposure:
Emergency and First Aid Procedures:
If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel. Get
immediate medical attention. If swallowed, wash out mouth with water provided person is conscious. Never give
anything by mouth to an unconscious person. Give plenty of water or milk to dilute the substance and induce
vomiting. Get immediate medical attention. In case of contact with eyes, hold eyelids apart and flush eyes with plenty
of water. After initial flushings, remove any contact lenses and continue flushing for at least 15 minutes. Have eyes
examined and tested by medical personnel. In case of skin contact, immediately wash skin with soap and plenty of
water. Remove contaminated clothing. Get medical attention if symptoms occur or irritation persists. Wash clothing
before reuse.
SECTION VII - Precautions for Safe Handling and Use
Trichostatin A
Steps To Be Taken In Case Material Is Released Or Spilled:
Absorb the liquid and scrub the area with detergent and water.
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Waste Disposal Method:
Dispose in accordance with local, state and federal regulations.
Hazard Label Information: Avoid contact with skin and eyes. Do not reuse this container. Use with adequate
ventilation. Wash thoroughly after handling.
Precautions To Be Taken in Handling and Storing:
Avoid contact with eyes, skin, and clothing. Do not reuse this container. Store at correct temperature. Use with
adequate ventilation. Wash thoroughly after handling.
Other Precautions:
SECTION VIII- Control Measures
Trichostatin A
Protective Equipment Summary - Hazard Label Information Eye wash station in work area Lab coat Latex
disposable gloves Safety glasses Safety shower in work area Vent Hood
Respiratory Equipment (Specify Type):
Ventilation:
Good general ventilation should be sufficient to control airborne levels.
Eye Protection:
Safety glasses
Protective Gloves:
Latex disposable gloves
Other Protective Clothing:
Lab coat
Work/Hygienic/Maintenance Practices:
Do not take internally. Facilities storing or utilizing this material should be equipped with an eyewash facility and a
safety shower. Wash thoroughly after handling.
SECTION IX - Additional Comments
Trichostatin A
For research use only, not for human or veterinary clinical use.
For research use only, not for human or veterinary clinical use. DISCLAIMER:
This information is believed to be accurate and represents the best information currently available to us. However, we
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make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and
we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of
the information for their particular purposes.
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