MATERIAL SAFETY DATA SHEET Page: 1
Arachidonic Acid
Cayman Chemical Company
Printed: 11/11/2005
1180 E. Ellsworth Rd.
Revision: 11/11/2005
Ann Arbor, MI 48108
Supercedes Revision: 04/07/2000
Date Created: 06/27/1996
1. Product and Company Identification
Product Code: 90010
Product Name: Arachidonic Acid
Manufacturer Information
Company Name: Cayman Chemical Company
Emergency Contact: Cayman Chemical Company (800)364-9897
Information: Cayman Chemical Company (734)971-3335
Chemical Family: Fatty Acids
Synonyms: 5Z,8Z,11Z,14Z-eicosatetraenoic acid;
2. Composition/Information on Ingredients
Hazardous Components (Chemical Name) CAS # Percentage OSHA PEL ACGIH TLV Other Limits
1. Arachidonic acid 506-32-1 10.0 % No data. No data. No data.
2. Ethyl alcohol 64-17-5 90.0 % 8H TWA:1000 ppm 1000 ppm No data.
(1900 mg/m3)
Hazardous Components (Chemical Name) RTECS # OSHA STEL OSHA CEIL ACGIH STEL ACGIH CEIL
1. Arachidonic acid CE6675000 No data. No data. No data. No data.
2. Ethyl alcohol KQ6300000 No data. No data. No data. No data.
3. Hazards Identification
Emergency Overview: No data available.
Route(s) of Entry: Inhalation? Yes Skin? Yes Eyes? Yes Ingestion? Yes Other: Injection
Potential Health Effects (Acute and Chronic): Long term repeated oral exposure to ethanol may result in the development of progressive liver
injury with fibrosis.
Material is irritating to the mucous membranes and upper respiratory tract.
May be harmful by inhalation, ingestion, or skin absorption.
May cause eye, skin, or respiratory system irritation.
Repeated exposure may cause skin dryness or cracking.
Repeated ingestion of ethanol by pregnant mothers has been shown to adversely affect the CNS
system of the fetus, producing a collection of effects which together consitutue fetal alcohol
syndrome. These include mental and physical retardation, disturbances of learning, motor and
language deficiencies, behavioral disorders and small size head.
The toxicological properties of this compound have not been fully evaluated.
Signs and Symptoms Of Exposure: Exposure may cause: Dizziness, drowsiness, headache, nausea, and vomiting.
Medical Conditions Generally Aggravated By Repeated exposure to ethanol may aggravate liver injury produced from other causes.
Exposure:
4. First Aid Measures
Emergency and First Aid Procedures: If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained
personnel. Get immediate medical attention.
If swallowed, wash out mouth with water provided person is conscious. Never give anything by
mouth to an unconscious person. Get medical attention. Do NOT induce vomiting unless directed
to do so by medical personnel.
In case of contact with eyes, hold eyelids apart and flush eyes with plenty of water. After initial
flushings, remove any contact lenses and continue flushing for at least 20 minutes. Have eyes
examined and tested by medical personnel.
In case of skin contact, immediately wash skin with soap and plenty of water. Remove
contaminated clothing. Get medical attention if symptoms occur. Wash clothing before reuse.
ANSI Z400.1 Format
MATERIAL SAFETY DATA SHEET Page: 2
Printed: 11/11/2005
Arachidonic Acid Revision: 11/11/2005
Supercedes Revision: 04/07/2000
5. Fire Fighting Measures
Flash Pt: 14.00 C Method Used: TCC
Explosive Limits: LEL: 3.3% at 25.0 C UEL: 19% at 25.0 C
Autoignition Pt: No data.
Fire Fighting Instructions: As in any fire, wear self-contained breathing apparatus pressure-demand (MSHA/NIOSH
approved or equivalent), and full protective gear to prevent contact with skin and eyes.
Note: Flammable as diluted in ethanol.
Flammable Properties and Hazards: Can release vapors that form explosive mixtures at temperatures at or above the flashpoint.
Container explosion may occur under fire conditions.
Emits toxic fumes under fire conditions.
Forms explosive mixtures in air.
Flammable liquid.
May form explosive peroxides.
May violently self-ignite forming foul smelling, irritating vapor if open vials are stored too long.
Vapors can travel to a source of ignition and flash back.
Hazardous Combustion Products: carbon dioxide
carbon monoxide
Extinguishing Media: Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray when fighting fires
involving this material.
Unsuitable Extinguishing Media: No data available.
6. Accidental Release Measures
Steps To Be Taken In Case Material Is Absorb spill with inert material (e.g. dry sand or earth), then place in a chemical waste container.
Released Or Spilled: After removal, ventilate contaminated area and flush thoroughly with water.
7. Handling and Storage
Hazard Label Information: Avoid contact with skin and eyes. Do not reuse this container. Use with adequate ventilation.
Wash thoroughly after handling.
Precautions To Be Taken in Handling: Avoid breathing (dust, vapor, mist, gas).
Avoid contact with eyes, skin, and clothing.
Avoid prolonged or repeated exposure.
Do not reuse this container.
Keep away from sources of ignition.
Use with adequate ventilation.
Wash thoroughly after handling.
Precautions To Be Taken in Storing: Keep tightly closed.
Store at correct temperature.
Store under nitrogen.
8. Exposure Controls/Personal Protection
Protective Equipment Summary - Hazard Eye wash station in work area Lab coat Latex disposable gloves Safety glasses Safety
Label Information: shower in work area Vent Hood
Respiratory Equipment (Specify Type): No data available.
Eye Protection: Safety glasses
Protective Gloves: Latex disposable gloves
Other Protective Clothing: Lab coat
Engineering Controls (Ventilation etc.): Good general ventilation should be sufficient to control airborne levels.
Work/Hygienic/Maintenance Practices: Do not take internally.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a
safety shower.
Wash thoroughly after handling.
ANSI Z400.1 Format
MATERIAL SAFETY DATA SHEET Page: 3
Printed: 11/11/2005
Arachidonic Acid Revision: 11/11/2005
Supercedes Revision: 04/07/2000
9. Physical and Chemical Properties
Physical States: [ ] Gas [ X ] Liquid [ ] Solid
Melting Point: No data.
Boiling Point: No data.
Autoignition Pt: No data.
Flash Pt: 14.00 C Method: TCC
Explosive Limits: LEL: 3.3% at 25.0 C UEL: 19% at 25.0 C
Specific Gravity (Water = 1): No data.
Vapor Pressure (vs. Air or mm Hg): 44.6 MM_HG at 20.0 C
Vapor Density (vs. Air = 1): No data.
Evaporation Rate (vs Butyl Acetate=1): No data.
Solubility in Water: 1.7 mg/ml* at 25.0 C
Other Solubility Notes: *0.1 M Na2CO3, sol. in EtOH, DMSO & DMF
Percent Volatile: N.A.
Corrosion Rate: No data.
Formula: C20H32O2
Molecular Weight: 304.50
pH: No data.
Appearance and Odor: A clear, colorless solution
10. Stability and Reactivity
Stability: Unstable [ ] Stable [ X ]
Conditions To Avoid - Instability: protect from air
protect from light
protect from moisture
Incompatibility - Materials To Avoid: bases
oxidizing agents
reducing agents
strong inorganic acids
strong oxidizing agents
Hazardous Decomposition Or Byproducts: carbon dioxide
carbon monoxide
Hazardous Polymerization: Will occur [ ] Will not occur [ X ]
Conditions To Avoid - Hazardous No data available.
Polymerization:
11. Toxicological Information
Toxicological Information: The toxicological effects of this compound have not been thoroughly studied.
Arachidonic Acid - Toxicity Data:
Intravenous LD50 (mouse): 39200 ug/kg
Chronic Toxicological Effects: Arachidonic Acid investigated as a mutagen and carcinogen.
Target Organ Data:
Maternal effects (uterus, cervix, vagina)
Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here.
See actual entry in RTECS for complete information.
Arachidonic Acid RTECS Number: CE6675000
Carcinogenicity/Other Information: No data available.
Carcinogenicity: NTP? No IARC Monographs? No OSHA Regulated? No
ANSI Z400.1 Format
MATERIAL SAFETY DATA SHEET Page: 4
Printed: 11/11/2005
Arachidonic Acid Revision: 11/11/2005
Supercedes Revision: 04/07/2000
12. Ecological Information
Ecological Information: Runoff from fire control or dilution water may cause pollution.
13. Disposal Considerations
Waste Disposal Method: Dispose in accordance with local, state and federal regulations.
14. Transport Information
LAND TRANSPORT (US DOT)
DOT Proper Shipping Name: Ethyl alcohol
DOT Hazard Class: 3
DOT Hazard Label: FLAMMABLE LIQUID
UN/NA Number: 1170
DOT Packing Group: II
Additional Transport Information: Transport in accordance with local, state, and federal regulations.
15. Regulatory Information
US EPA SARA Title III
Hazardous Components (Chemical Name) CAS # Sec.302 (EHS) Sec.304 RQ Sec.313 (TRI) Sec.110
1. Arachidonic acid 506-32-1 No No No No
2. Ethyl alcohol 64-17-5 No No No No
US EPA CAA, CWA, TSCA
Hazardous Components (Chemical Name) CAS # EPA CAA EPA CWA NPDES EPA TSCA CA PROP 65
1. Arachidonic acid 506-32-1 No No No No
2. Ethyl alcohol 64-17-5 No No No No
16. Other Information
Company Policy or Disclaimer
For research use only, not for human or veterinary clinical use.
DISCLAIMER: This information is believed to be accurate and represents the best information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should
make their own investigations to determine the suitability of the information for their particular purposes.
ANSI Z400.1 Format
|