MATERIAL SAFETY DATA SHEET
INDERMIL鈩? Tissue Adhesive
1. PRODUCT AND COMPANY IDENTIFICATION
INDERMIL鈩? Tissue Adhesive
Product Name
Tissue Adhesive
Use/Size
8886-028275, 8886-028830, 8886-029241, 8886-029242
Product Numbers
Tyco Healthcare/ Kendall
Manufacturer/Supplier
15 Hampshire Street
Address
Mansfield, MA 02048
(508) 261-8000 (Monday 鈥? Friday 8:00 am to 5:00 pm)
Phone Number
(800) 424-9300
Chemtrec Number
January 30, 2004
Revision Date:
September 22, 1998
MSDS Date:
This MSDS has been compiled in accordance with - EC Directive 91/155/EC - OSHA's Hazcom Standard (29 CFR 1910.1200)
2. COMPOSITION/INFORMATION ON THE COMPONENTS
Component Name CAS#/Codes Concentration R Phrases Classification
Enbucrilate 6606-65-1 >99.00% R-None None
(n-butyl-2-cyanoacrylate) 229-52-2
3. HAZARD IDENTIFICATION
EU Main Hazards
Not classified as hazardous.
Routes of Entry
- Eye contact - Skin contact - Inhalation
Carcinogenic Status
Not considered carcinogenic by NTP, IARC, and OSHA.
Target Organs
- Eye - Skin - Respiratory System
Health Effects - Eyes
May cause severe irritation. Highly reactive to water. Bonds in seconds. During period of eye
contamination double vision may occur. Cyanoacrylates attach to eye proteins and will disassociate
from them over intermittent periods. Weeping will occur until clearance is achieved.
Health Effects - Skin
Bonds in seconds. Material may cause irritation. May cause allergic skin reaction.
Health Effects - Ingestion
Unlikely exposure route due to rapid polymerization. Bonds in seconds to oral tissues. Saliva will lift
adhesive in one half to two days.
Health Effects - Inhalation
May cause contact sensitization and upper respiratory tract irritation.
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Revision Date: January 30, 2004
MATERIAL SAFETY DATA SHEET
INDERMIL鈩? Tissue Adhesive
4. FIRST AID MEASURES
Eyes
If the eye is bonded closed, release eyelashes with warm water by covering with a wet pad.
Cyanoacrylates will bond to eye protein causing a lacryamatory effect which will help to debond the
adhesive. Keep eye covered with a wet pad until the debonding is complete, usually within 1 to 3
days. Do not force eye open. Medical advice should be sought in cases where solid particles of
cyanoacrylate become trapped behind the eyelid, as this may cause abrasive damage.
Skin
Do not pull bonded skin apart. It may be gently peeled apart using a blunt instrument such as a
spoon, preferably with the aid of warm soapy water. Presoaking in a 5% solution of sodium
bicarbonate will further assist separation.
Ingestion
Do not induce vomiting. Have victim drink 1-3 glasses of water to dilute stomach contents. Never
administer anything by mouth if a victim is losing consciousness, is unconscious or is convulsing.
Obtain medical attention immediately.
Inhalation
Remove to fresh air. Seek medical attention if symptoms persist.
Advice to Physicians
Treat symptomatically.
5. FIRE FIGHTING MEASURES
Extinguishing Media
Use foam, dry chemical or carbon dioxide.
Unusual Fire and Explosion Hazards
This product may give rise to hazardous fumes in a fire.
Protective Equipment for Fire-Fighting
Wear full protective clothing and self-contained breathing apparatus.
6. ACCIDENTAL RELEASE MEASURES
Liquid dries within 15-45 seconds without the aid of catalysts, heat or solvent evaporation. Use water
spray to polymerize and scrape off of the floor. Transfer into suitable containers for recovery or
disposal. Ventilate the area. Wear appropriate protective clothing. Prevent the material from
entering drains or watercourses.
7. HANDLING AND STORAGE
Use in well ventilated area. When used in large volumes or odor becomes apparent use local exhaust
ventilation. When used in small quantities good general room ventilation is expected to be adequate
to control exposures. Keep container tightly closed when not in use. Avoid contact with eyes, skin and
clothing. Store product in refrigerator. Storage temperature should be controlled to between 2 and 5
掳C. Do not put residual material back into the container as contamination may reduce the shelf-life of
the bulk product.
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MATERIAL SAFETY DATA SHEET
INDERMIL鈩? Tissue Adhesive
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Occupational Exposure Standards
Exposure limits are listed below, if they exist.
Enbucrilate (n-butyl-2-cyanoacrylate)
None assigned.
Engineering Control Measures
Engineering methods to prevent or control exposure are preferred. Methods include process or
personnel enclosure, mechanical ventilation (dilution and local exhaust), and control of process
conditions to keep airborne levels at acceptable levels, as appropriate.
Respiratory Protection
Respiratory protection not normally required.
Hand Protection
Chemical resistant gloves. Polyethylene is recommended (not cotton).
Eye Protection
Chemical goggles or safety glasses with side shields
Body Protection
Wear: - lab coat - surgical gowns - trousers
9. PHYSICAL AND CHEMICAL PROPERTIES
Liquid
Physical State
Colorless
Color
Characteristic
Odor
No data.
pH
No data.
Specific Gravity
>100 / 212
Boiling Range/Point (掳C/F)
>80 / >176
Flash Point (PMCC) (掳C/F)
No data.
Auto-flammability (deg C)
No data.
Explosion Limits (%)
<0.5 mmHg at 25 掳C.
Vapor Pressure
No data.
Density
Insoluble
Solubility in Water
No data.
Vapor Density (Air = 1)
No data.
Viscosity (cSt)
10. STABILITY AND REACTIVITY
Stability
Polymerization will continue if exposed to: - alkalis - water - amines - alcohols
Conditions to Avoid
- Heat - High temperatures
Materials to Avoid
- Amines - Alcohols - Bases - Water
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MATERIAL SAFETY DATA SHEET
INDERMIL鈩? Tissue Adhesive
10. STABILITY AND REACTIVITY
Hazardous Polymerization
Will not occur.
Hazardous Decomposition Products
- acrid smoke and irritating fumes - oxides of carbon - oxides of nitrogen
11. TOXICOLOGICAL INFORMATION
Acute Toxicity
Aqueous extracts (maximal level: 5.5 mg/ml) of Indermil鈩? polymerized in thin sheets on glass and
tested in a Chineses hamster lung cell line (V79) with and without rat liver derived metabolizing
enzymes and was shown not to be toxic.
There is a reduced risk by inhalation due to the absence of solvents. However, cyanoacrylate vapors
are irritating to eyes and mucous membranes. Prolonged and repeated overexposure to vapor may
product allergic reactions (rhinitis) with asthma-like symptoms in certain individuals. In the event of
fire or heating cyanoacrylate adhesives increase their volatility creating an increased risk of
respiratory irritation and sensitization.
Liquid Indermil鈩? monomer when in direct contact with the intact skin is not expected to be irritating.
However, it is irritating to broken or abraded skin, based on OECD testing Guidelines 404 and 405;
US 16 CR.100.42 1500.41 & 42. Due to the rapid polymerization at the skin surface, contact with the
liquid Indermil鈩? represents a low order of systemic toxicity by this exposure route. A contact
dermatitis may occur after chronic repetitive exposures of the skin to the liquid monomer.
The ocular toxicity of several cyanoacrylate monomers (ethyl, isobutyl, octyl, and decyl) have been
studied in guinea pigs. All produced an inflammatory response. Weeping, double vision and
lacrimation until the polymerization process is complete may occur. Although cured cyanoacrylates
(polymer) will not bond to the surface of the eye, corneal damage from abrasion may result. Irritation
with pain, corneal abrasions, keratoconjunctivitis and punctate epitheliopathy results; eyelash loss
occurs.
Chronic exposure to volatile monomer (vapors) may cause giant papillary conjunctivitis.
Ingestion does not produce toxicity since polymerization occurs so rapidly that little, if any, of the
monomer passes beyond the oropharynx. Almost impossible to swallow due to rapid polymerization.
Chronic Toxicity/Carcinogenicity
This product is not expected to cause long-term adverse health effects.
Genotoxicity
The product did not exhibit any mutagenic or clastogenic activity in a variety of bacterial and
mammalian systems in vitro. This product is not expected to cause any mutagenic effects.
Reproductive/Developmental Toxicity
This product is not expected to cause reproductive or developmental health effects.
12. ECOLOGICAL INFORMATION
Mobility
No relevant studies identified.
Persistence/Degradability
The product is partially or slowly biodegradable.
Bio-accumulation
Product is not expected to bioaccumulate.
Ecotoxicity
No relevant studies identified.
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MATERIAL SAFETY DATA SHEET
INDERMIL鈩? Tissue Adhesive
13. DISPOSAL
Flood with water to polymerize. Soak up with an inert absorbent. Dispose of in accordance with all
applicable local and national regulations.
14. TRANSPORT INFORMATION
Not Regulated
DOT CFR 172.101 Data
Not Regulated
UN Proper Shipping Name
None.
UN Class
None.
UN Number
None.
UN Packaging Group
Consult current IATA Regulations prior to shipping by air.
Classification for AIR
Transportation (IATA)
15. REGULATORY INFORMATION
EU Label Information
Classification and labelling have been performed according to EU directives 67/548/EEC and
99/45/EC including amendments.
EU Hazard Symbol and Indication of Danger
According to EC Commission Directive 67/548/EEC this product is not classified.
R phrases
None.
S phrases
None.
US REGULATIONS (Federal, State) and INTERNATIONAL CHEMICAL REGISTRATION LAWS
TSCA Listing
All ingredients have been verified for inclusion on the EPA Toxic Substance Control Act Chemical
Substance Inventory.
EINECS Listing
All ingredients in this product are listed on the European Inventory of Existing Commercial Chemical
Substances (EINECS) or the European List of New Chemical Substances (ELINCS) or are exempt
from listing.
DSL/NDSL (Canadian) Listing
Ingredient(s) in this product are listed on the Non-Domestic Substance List (NDSL).
MA Right To Know Law
This product does not contain any chemicals listed on the Massachusetts Right To Know Substance
List.
PA Right To Know Law
This product does not contain any chemicals on the Pennsylvania Hazardous Substance List.
NJ Right To Know Law
This product does not contain any chemicals on the New Jersey Workplace Hazardous Substance
List.
California Proposition 65
This product does not contain materials which the State of California has found to cause cancer, birth
defects or other reproductive harm.
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Revision Date: January 30, 2004
MATERIAL SAFETY DATA SHEET
INDERMIL鈩? Tissue Adhesive
15. REGULATORY INFORMATION
SARA Title III Sect. 302 (EHS)
This product does not contain any chemicals subject to SARA Title III Section 302.
SARA Title III Sect. 304
This product does not contain any chemicals subject to SARA Title III Section 304.
SARA Title III Sect. 311/312 Categorization
This product does not meet any of the SARA Title III Section 311/312 categorizations.
SARA Title III Sect. 313
This product does not contain a chemical that is listed in Section 313 at or above de minimis
concentrations.
16. OTHER INFORMATION
NFPA Ratings
NFPA Code for Flammability - 0
NFPA Code for Health - 1
NFPA Code for Reactivity - 0
NFPA Code for Special Hazards - 0
HMIS Ratings
HMIS Code for Flammability - 0
HMIS Code for Health - 1
HMIS Code for Reactivity - 0
HMIS Code for Personal Protection - See Section 8
Abbreviations
N/A: Denotes no applicable information found or available
CAS#: Chemical Abstracts Service Number
ACGIH: American Conference of Governmental Industrial Hygienists
OSHA: Occupational Safety and Health Administration
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
STEL: Short Term Exposure Limit
NTP: National Toxicology Program
IARC: International Agency for Research on Cancer
EU: European Union
R: Risk
S: Safety
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
BOD: Biological Oxygen Demand
KoC: Soil Organic Carbon Partition Coefficient
EnviroNet LLC.
Prepared By:
The information and recommendations presented in this MSDS are based on sources believed to be
accurate; therefore, The Kendall Company assumes no liability for the accuracy or completeness of
this information. It is the user's responsibility to determine the suitability of the information for their
particular purposes.
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Revision Date: January 30, 2004
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