MSDS Trivalent
TICK FEVER CENTRE, WACOL
MATERIAL SAFETY DATA SHEET
TRIVALENT TICK FEVER VACCINE
Department of Primary Industries and Fisheries, Queensland
Biosecurity
Tick Fever Centre
280 Grindle Road, Wacol Queensland 4076 Australia
Telephone: +61 7 3898 9655
Fax: +61 7 3898 9685
E-mail: tfc@dpi.qld.gov.au
Web-site: http://www.dpi.qld.gov.au/tickfever/
IDENTIFICATION
TRIVALENT TICK FEVER VACCINE
Product Name:
Other Names: Trivalent chilled vaccine
Manufacturer鈥檚 Product Code: TRV/10, 20, 25, 50, 100.
UN Number: None allocated
Dangerous Goods Class and None allocated, no subsidiary risk
Subsidiary Risk
Hazchem Code: None allocated
Poisons Schedule Number: Not scheduled
Use: Prevention of Tick Fever (Bovine Babesiosis and
Anaplasmosis) by vaccination in cattle.
Physical Description/Properties:
Appearance: Liquid blood based vaccine packed in polypropylene
pillow packs
No data. Expected to be about 1000C
Boiling Point
Vapour Pressure: No data
Specific Gravity: Approximately 0.97
Flammability: Does not burn
Corrosiveness: Not corrosive
Rev: 5
Ref: MSDS 3
Date of Issue: 4/09/07
Page 1 of 5
MSDS Trivalent
TICK FEVER CENTRE, WACOL
MATERIAL SAFETY DATA SHEET
TRIVALENT TICK FEVER VACCINE
Other Properties:
Ingredients: Contains live attenuated tick fever organisms (Babesia bovis,
Babesia bigemina and Anaplasma centrale) in bovine blood
diluted with a cell free diluent. The diluent consists of 10%
bovine serum in an isotonic balanced salt solution.
Each 2 mL dose of trivalent vaccine contains:
(i) Mixed bovine blood containing Babesia bovis &
centrale (107 of each organism)&
Anaplasma
Babesia bigemina (2.5 x 106 organisms).
Maximum blood = 1.20 mL
Minimum blood = 0.06 mL
Average blood = 0.12 mL
Vaccine Diluent Formulation
Sodium Chloride (NaCl) 119.8 mM
Magnesium Chloride (MgCl2) 1.5 mM
Glucose (C6 H12 O6) 5.6 mM
Disodium hydrogen orthophosphate (Na2 HPO4) 17.8 mM
Potassium Dihydrogen orthophosphate (KH2 PO4) 5.1mM
Sodium hydrogen carbonate (Na HCO3) 6.1mM
Benzylpenicillin 500,000 units/litre
Streptomycin sulphate 500 mg/litre
Sterile bovine serum 100 mLs/litre
Rev: 5
Ref: MSDS 3
Date of Issue: 4/09/07
Page 2 of 5
MSDS Trivalent
TICK FEVER CENTRE, WACOL
MATERIAL SAFETY DATA SHEET
TRIVALENT TICK FEVER VACCINE
HEALTH HAZARD INFORMATION
HEALTH EFFECTS No specific data are available for the product for chronic
exposure symptoms. The vaccine is non toxic and the live
organisms contained in the vaccine are harmless to humans.
The vaccine is not classified as hazardous according to the
criteria of Worksafe Australia.
However the following people may be at increased risk after
self-injection:
鈥? Elderly Persons
鈥? Persons with weakened immune systems eg. Persons
whose immune system has been altered by diseases such as
leukaemia, lymphoma or through drugs and radiation or
HIV or AIDS sufferers; and
鈥? Persons whose spleen has been removed.
Acute Swallowing, skin contact, eye contact or inhalation:
According to the present state of knowledge provided that this
product is handled correctly, there is no known danger to
humans. The product contains low levels of Benzylpenicillin
and Streptomycin Sulphate antibiotics and individuals allergic
to these antibiotics should avoid self-injection or ingestion.
FIRST AID
WARNING: You should seek medical advice if accidental self-injection occurs
Self injection: Accidental self-injection may lead to an inflammatory
response and medical advice should be sought on the
management of deep injections, particularly those near a joint
or associated with bruising. If possible the application of
gentle squeezing pressure with absorbent material (eg facial
tissues) at the injection site will swab up unabsorbed vaccine.
Strong squeezing of the site should be avoided. The damaged
area should be thoroughly cleansed and a topical antiseptic
applied.
Rev: 5
Ref: MSDS 3
Date of Issue: 4/09/07
Page 3 of 5
MSDS Trivalent
TICK FEVER CENTRE, WACOL
MATERIAL SAFETY DATA SHEET
TRIVALENT TICK FEVER VACCINE
Swallowed: If in mouth, thoroughly wash mouth with water, then give
some water to drink. Further measures should not be
necessary.
Eye: If this product comes into contact with eyes, hold open and
wash well with clean running water. Ensure irrigation under
eyelids by occasionally lifting them. Do not try to remove
contact lenses unless trained.
Skin: If this product comes into contact with skin, wash skin with
soap and water.
Advice to Doctor: Accidental self injection may lead to an inflammatory
response and deep injections, particularly those near a joint or
associated with bruising should be treated medically or
surgically. The vaccine contains low levels of the antibiotics
Benzylpenicillin and Streptomycin Sulphate as preservatives
(approximately 500 units of benzylpenicillin and 0.5 mg
streptomycin sulphate per mL of vaccine).
There is no convincing evidence that the organisms used in the
vaccine (Babesia bovis, Babesia bigemina and Anaplasma
centrale) are infective for humans. However related
organisms present overseas including Babesia microti and
Babesia divergens have been shown to be able to infect and
cause disease especially in elderly and immune compromised
individuals. The organisms are intra-erythrocytic parasites
and the disease syndrome can resemble malaria. More
information on the zoonotic disease seen in the United States
can be found on the web-site
鈥渉ttp://www.riaes.org/resources/ticklab/babesia.html鈥?
PRECAUTIONS FOR USE
Exposure Standards: None available
Engineering Controls: Not applicable
Personal Protection: Avoid self-injection
Flammability: Does not burn
Rev: 5
Ref: MSDS 3
Date of Issue: 4/09/07
Page 4 of 5
MSDS Trivalent
TICK FEVER CENTRE, WACOL
MATERIAL SAFETY DATA SHEET
TRIVALENT TICK FEVER VACCINE
SAFE HANDLING INFORMATION
Store at 20 to 80 C (refrigerate, do not freeze)
Storage and Transport:
Spills: N/A non hazardous
Disposal: Dispose of empty containers and outer packaging by
wrapping with paper and putting in garbage. Discarded
needles should be placed in a designated and appropriately
labelled 鈥榮harps鈥? container. The container should be of a type
to reduce the possibility of injury to handlers during collection
and disposal. Incineration is the preferred method of disposal,
otherwise 鈥榮harps鈥? should be buried at a suitable site, such as
on farm chemical disposal pit located away from watercourses.
Fire/Explosion Hazard: N/A
OTHER INFORMATION
This MSDS has been prepared in accord with the Worksafe Australia 鈥楴ational Code for
Preparation of Material Safety Data Sheets, 1994鈥?.
CONTACT POINT
Contact an adviser at: Department of Primary Industries and Fisheries, Queensland
Biosecurity
Tick Fever Centre
280 Grindle Road
Wacol Queensland 4076 Australia
Telephone: +61 7 3898 9655
Fax: +61 7 3898 9685
E-mail: tfc@dpi.qld.gov.au
Web-site: http://www.dpi.qld.gov.au/tickfever/
Rev: 5
Ref: MSDS 3
Date of Issue: 4/09/07
Page 5 of 5
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