**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 133073-73-1 |L-(+)-Amethopterin hydrate | 99 | unlisted |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T
Risk Phrases: 25 46 61
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Toxic if swallowed. May cause heritable genetic damage. May cause
harm to the unborn child.Hygroscopic (absorbs moisture from the
air).Light sensitive.Mutagen.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May be harmful if absorbed through the skin.
Ingestion:
Poison by ingestion. Exposure may cause anemia and other blood
abnormalities. May cause bone marrow depression. Ingestion may result
in irritation of the esophagus, bleeding of the stomach and ulcer
formation.
Inhalation:
May cause effects similar to those described for ingestion. May
cause respiratory tract irritation. May cause lung damage.
Chronic:
May cause liver and kidney damage.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid immediately. Do NOT induce vomiting. If conscious and alert,
rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. If breathing is difficult, give oxygen.
Do not use mouth-to-mouth resuscitation if victim ingested or inhaled
the substance; induce artificial respiration with the aid of a pocket
mask equipped with a one-way valve or other proper respiratory
medical device.
Notes to Physician:
Antidote:
Charcoal hemoperfusion is recommended.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Runoff from
fire control or dilution water may cause pollution.
Extinguishing Media:
In case of fire, use carbon dioxide, dry chemical powder or
appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Minimize dust generation and accumulation. Do not
get in eyes, on skin, or on clothing. Keep container tightly closed.
Do not ingest or inhale. Store protected from light. Use only in a
chemical fume hood. Keep from contact with moist air and steam.
Storage:
Deep freeze (below -20C). Keep containers tightly closed. Store
protected from moisture. Store protected from light.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use only under a
chemical fume hood.
Exposure Limits
CAS# 133073-73-1:
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Crystalline powder
Color: yellow
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 195 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 195 deg C
Solubility in water: insoluble
Specific Gravity/Density: Not available.
Molecular Formula: C20H22N8O5.2H2O
Molecular Weight: 490.47
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Decomposes on exposure to light. Hygroscopic: absorbs moisture or
water from the air.
Conditions to Avoid:
Light, dust generation, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 133073-73-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
L-(+)-Amethopterin hydrate -
Not listed by ACGIH, IARC, or NTP.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Other
No information available.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: III
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 46 May cause heritable genetic damage.
R 61 May cause harm to the unborn child.
R 25 Toxic if swallowed.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 28A After contact with skin, wash immediately with
plenty of water.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 133073-73-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 133073-73-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 133073-73-1 is not listed on the TSCA inventory.
It is for research and development use only.
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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