*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OT0700000
CHEMICAL NAME : l-Menthol
CAS REGISTRY NUMBER : 2216-51-5
LAST UPDATED : 199701
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C10-H20-O
MOLECULAR WEIGHT : 156.30
WISWESSER LINE NOTATION : L6TJ AY1&1 DQ D1 -L
COMPOUND DESCRIPTOR : Mutagen
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* (-)-Menthol
* (1R,3R,4S)-(-)-Menthol
* (-)-Menthyl alcohol
* (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
* U.S.P. Menthol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1%
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.3- 1930- Volume(issue)/page/year: 17(3),53,1962
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 35,110,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21,
1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year:
5,233,1932
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.3- 1930- Volume(issue)/page/year: 17(3),53,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 34 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 63,43,1939
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,471,1976
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 44A,58,1967
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 63,43,1939
** MUTATION DATA **
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 10 mg/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association.
(Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho,
Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year:
34,267,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6896
No. of Facilities: 499 (estimated)
No. of Industries: 5
No. of Occupations: 27
No. of Employees: 43996 (estimated)
No. of Female Employees: 34625 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
para-Menth-1-en-4-ol
| 562-74-3 |
p-Menth-1-en-8-ol, (+-)-
| 2438-12-2 |
p-Menth-8-en-1-ol
| 138-87-4 |
p-Menth-8-en-2-ol
| 619-01-2 |
p-Menth-8-en-3-ol
| 7786-67-6 |
p-Menth-1-en-8-ol, acetate
| 80-26-2 |
Mandelamide, alpha-methyl-
| 2019-68-3 |
p-Menth-8-en-2-ol, acetate
| 20777-49-5 |
p-Menth-1-en-8-ol, formate (mixed isomers)
| 2153-26-6 |
p-Menth-1-en-3-one
| 89-81-6 |
p-Menth-4(8)-en-3-one
| 15932-80-6 |
p-Menth-4(8)-en-3-one, (R)-(+)-
| 89-82-7 |
p-Menth-8-en-2-one
| 7764-50-3 |
p-Menth-8-en-3-one, trans-
| 29606-79-9 |
L-Methionine, N-(1-oxo-3-phenyl-2-propenyl)-, methylester, (E)-
| 127750-59-8 |
Menthol
| 89-78-1 |
Menthol, (+)-neo-
| 63975-60-0 |
Mandelamide, N-(4-methyl-2-pyridyl)-, hydrochloride
| 3372-94-9 |
Menthol, trans-1,3,cis-1,4-, (+)-
| 63903-52-6 |
dl-Menthol
| 15356-70-4 |
l-Menthol
| 2216-51-5 |
Menthol, cis-1,3-cis-1,4-(+-)-
| 3623-52-7 |
Menthol, trans-1,3-cis-1,4-(+-)-
| 3623-51-6 |
Menthol, isovalerate
| 16409-46-4 |
Mentor 28
| 63148-53-8 |
Mentzelia decapetala (pursh.) Urb. & Gilg., alkaloidextractSUBSTANCE DEFINITION :Alkaloids obtained from the plant belonging to the family LoasaceaeREFERENCE :JNPRDF Journal of Natural Products. (Spahr & Glenn Co., 225 E. Spring St.,Columbus, OH 43215) V.42- 1979- Volume(issue)/page/year: 44,693,1981
| 63148-53-8 |
p-Mercapto sulfadiazine
| 67479-03-2 |
Mercurate(1-), acetatophenyl-, ammonium salt
| 34604-38-1 |
Mandelamide, N-(5-methyl-2-pyridyl)-, hydrochloride
| 1086-88-0 |
Mercurate(1-), (acetato-O)amidophenyl-, hydrogen
| 53404-67-4 |
Mercurate(1-), amidophenyl(propanoato-O)-, hydrogen
| 53404-68-5 |
Mercurate(4-),bis(N,N-bis(carboxymethyl)glycinato(3-)-N,O,O',O'')-,tetrahydrogen
| 73128-65-1 |
Mercurate(1-), butyl(mercaptoacetato(2-)-O,S-),sodium
| 64048-05-1 |
Mercurate(1-),(3-(5-carboxylato-1,2-dihydro-2-oxo-1-pyridinyl)-2-methoxypropyl)hydroxy-, sodium, compd. with3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
| 7097-62-3 |
Mercurate(1-)-,(3-(4-(carboxylatomethoxy)phenyl)-2-hydroxypropyl)hydroxy-, sodium
| 63907-33-5 |
Mercurate(1-),(3-((((3-carboxylato-1-oxopropyl)amino)carbonyl)amino)-2-methoxypropyl) hydroxy-, sodium, mixed with3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
| 8069-64-5 |
Mercurate(2-), ((cyclohexylenedinitrilo)tetracetato)-
| 8069-64-5 |
Mercurate(1-), (L-cysteinato(2-)-S)methyl-, hydrogen
| 32754-35-1 |
Mercurate(1-), ethyl(mercaptoacetato(2-)-O,S)-,potassium
| 64048-06-2 |
Mandelamide, N-phenyl-alpha-propyl-
| 39164-86-8 |
Mercurate(1-), (mercaptoacetato(2-)-O,S)methyl-,sodium
| 64048-07-3 |
Mercurate (2-), tetraiodo-, dipotassium
| 7783-33-7 |
Mercury
| 7439-97-6 |
Mercury, (3-acetamido-2-methoxypropyl)chloro-
| 7439-97-6 |
Mercury,acetato(5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)-
| 7439-97-6 |
Mercury, acetato(2-amino-5-carboxyphenyl)-
| 7439-97-6 |
Mercury, acetato(4-amino-2-carboxyphenyl)-
| 7439-97-6 |
Mercury, acetato(4-amino-3-carboxyphenyl)-
| 7439-97-6 |
Mercury, acetato(5-amino-2-hydroxyphenyl)-
| 7439-97-6 |
Mercury,(acetato-O)(3-((4-amino-6-methyl-1,3,5-triazin-2-yl)amino)-2-hydroxypropyl )-
| 7439-97-6 |
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