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MSDS  : 2,7-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy-4,4'-biphenylylene)bis(azo))bis ( 5-amino-4-hydroxy-, tetrasodium salt
CAS  : 2429-74-5
SYNONYMS  : * Airedale Blue D * Aizen Direct Sky Blue 5B * Aizen Direct Sky Blue 5BH * Amanil Sky Blue * Atlantic Sky Blue A * Atul Direct Sky Blue * Azine Sky Blue 5B * Belamine Sky Blue A * Benzanil Sky Blue * Benzo Sky Blue S * Benzo Sky Blue A-CF * Cartasol Blue 2GF * Chloramine Sky Blue A * Chloramine Sky Blue 4B * Chrome Leather Pure Blue * C.I. 24400 * C.I. Direct Blue 15 * C.I. Direct Blue 15, tetrasodium salt * Cresotine Pure Blue * Diacotton Sky Blue 5B * Diamine Blue * Diamine Blue 6B * Diamine Sky Blue * Diamine Sky Blue CI * Diaphtamine Pure Blue * Diazol Pure Blue 4B * Diphenyl Brilliant Blue * Diphenyl Sky Blue 6B * Direct Blue 15 * Direct Blue 10G * Direct Blue HH * Direct Pure Blue * Direct Pure Blue M * Direct Sky Blue A * Direct Sky Blue 5B * Enianil Pure Blue AN * Fenamin Sky Blue * Hispamin Sky Blue 3B * Kayafect Blue Y * Kayaku Direct Sky Blue 5B * Mitsui Direct Sky Blue 5B * Modr Prima 15 * Naphtamine Blue 10G * NCI C61290 * Niagara Blue 4B * Niagara Sky Blue * Nippon Direct Sky Blue * Nippon Sky Blue * Nitto Direct Sky Blue 5B * Oxamine Sky Blue 5B * Paper Blue S * Phenamine Sky Blue A * Pontamine Sky Blue 5BX * Pontacyl Sky Blue 4BX * Shikiso Direct Sky Blue 5B * Sky Blue 4B * Sky Blue 5B * Tertrodirect Blue F * Vondacel Blue HH
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : QJ6420000
CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid,
3,3'-((3,3'-dimethoxy-4,4'-biphenylylene)bis(azo))bis
( 5-amino-4-hydroxy-, tetrasodium salt
CAS REGISTRY NUMBER : 2429-74-5
OTHER CAS REGISTRY NOS. : 51568-94-6
95032-75-0
LAST UPDATED : 199710
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C34-H24-N6-O16-S4.4Na
MOLECULAR WEIGHT : 992.84
WISWESSER LINE NOTATION : L66J BQ DSWO HSWO JZ CNUNR CO1 DR BO1 DNUN- CL66J BQ
DSWO HSWO JZ &-NA- 4
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Airedale Blue D
* Aizen Direct Sky Blue 5B
* Aizen Direct Sky Blue 5BH
* Amanil Sky Blue
* Atlantic Sky Blue A
* Atul Direct Sky Blue
* Azine Sky Blue 5B
* Belamine Sky Blue A
* Benzanil Sky Blue
* Benzo Sky Blue S
* Benzo Sky Blue A-CF
* Cartasol Blue 2GF
* Chloramine Sky Blue A
* Chloramine Sky Blue 4B
* Chrome Leather Pure Blue
* C.I. 24400
* C.I. Direct Blue 15
* C.I. Direct Blue 15, tetrasodium salt
* Cresotine Pure Blue
* Diacotton Sky Blue 5B
* Diamine Blue
* Diamine Blue 6B
* Diamine Sky Blue
* Diamine Sky Blue CI
* Diaphtamine Pure Blue
* Diazol Pure Blue 4B
* Diphenyl Brilliant Blue
* Diphenyl Sky Blue 6B
* Direct Blue 15
* Direct Blue 10G
* Direct Blue HH
* Direct Pure Blue
* Direct Pure Blue M
* Direct Sky Blue A
* Direct Sky Blue 5B
* Enianil Pure Blue AN
* Fenamin Sky Blue
* Hispamin Sky Blue 3B
* Kayafect Blue Y
* Kayaku Direct Sky Blue 5B
* Mitsui Direct Sky Blue 5B
* Modr Prima 15
* Naphtamine Blue 10G
* NCI C61290
* Niagara Blue 4B
* Niagara Sky Blue
* Nippon Direct Sky Blue
* Nippon Sky Blue
* Nitto Direct Sky Blue 5B
* Oxamine Sky Blue 5B
* Paper Blue S
* Phenamine Sky Blue A
* Pontamine Sky Blue 5BX
* Pontacyl Sky Blue 4BX
* Shikiso Direct Sky Blue 5B
* Sky Blue 4B
* Sky Blue 5B
* Tertrodirect Blue F
* Vondacel Blue HH

*** HEALTH HAZARD DATA ***

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 52500 mg/kg/14D-C
TOXIC EFFECTS :
Liver - other changes
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-397,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/kg/13W
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-397,1992

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 168 gm/kg/96W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Brain and Coverings - tumors
Blood - leukemia
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-397,1992

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 70 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 127,215,1968

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 200 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 127,215,1968

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 140 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 2,85,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 5 gm/kg
SEX/DURATION : female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
20,177,1993

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 500 ug/plate
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 22,413,1980

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 18,111,1986

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,235,1993

IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,235,1993

IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,235,1993

TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 1,131,1966

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4514
No. of Facilities: 10 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 69 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4514
No. of Facilities: 485 (estimated)
No. of Industries: 7
No. of Occupations: 7
No. of Employees: 4527 (estimated)
No. of Female Employees: 201 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Carcinogenesis Studies (drinking);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-397,92


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy- 90-20-0
2,7-Naphthalenedisulfonic acid, 4-amino-3-hydroxy-,disodium salt 42579-07-7
2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-,disodium salt 3963-80-2
1,3-Naphthalenedisulfonic acid,4-amino-5-hydroxy-6-((4'-((2-hydroxy-1-naphthalenyl)azo)-3,3'-dimethoxy(1, 1'-biphenyl)-4-yl)azo)-,disodium salt 2586-57-4
2,7-Naphthalenedisulfonic acid,4-amino-5-hydroxy-6-((4'-((4-hydroxyphenyl)azo)(1,1'-biphenyl)-4-yl)azo)-3-((4-nitrophenyl)azo)-,disodium salt 4335-09-5
2,6-Naphthalenedisulfonic acid,4-amino-5-hydroxy-3-((4'-((4-hydroxyphenyl)azo)(1,1'-biphenyl)-4-yl)azo)-6-(phenylazo)-, disodium salt 3626-28-6
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,2-(4-nicotinoyl-1-piperazinyl) ethyl ester,dihydrochloride, (S)- 97699-66-6
2,7-Naphthalenedisulfonic acid,4-amino-5-hydroxy-3-((4-nitrophenyl)azo)-6-(phenylazo)-, disodium salt 1064-48-8
2,7-Naphthalenedisulfonic acid,4-amino-5-hydroxy-6-phenylazo-, disodium salt 3567-66-6
3,6-Naphthalenedisulfonic acid, 8-amino-7-hydroxy-,sodium salt 2007-20-7
2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-,p-toluenesulfonate (ester) 6837-93-0
2,7-Naphthalenedisulfonic acid,3-amino-4-((4'-((4-(((4-methylphenyl)sulfonyl)oxy)phenyl) azo)(1,1'-biphenyl)-4-yl)azo)-, disodium salt 2429-80-3
2,7-Naphthalenedisulfonic acid,4-((4-anilino-5-sulfo-1-naphthyl)azo)-5-hydroxy-,trisodium salt 3861-73-2
2,7-Naphthalenedisulfonic acid,3,3'-((4,4'-biphenylylene)bis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt 2602-46-2
1,5-Naphthalenedisulfonic acid,3-((p-(bis(2-chloroethyl)amino)phenyl)azo)- 101931-20-8
2,7-Naphthalenedisulfonic acid,3,6-(bis(4-((2-hydroxyethyl)sulfonyl)phenyl)bis(azo))- 5-amino-4-hydroxy-, di(hydrogen sulfate) ester,tetrasodium salt 17095-24-8
1,3-Naphthalenedisulfonic acid,7-(3-(p-butoxyphenyl)-2-thioureido)-, dipotassiumsalt 37556-92-6
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,2-(4-(1-oxo-3-phenyl-2-propenyl)-1- piperazinyl)ethylester, monohydrochloride, (S)- 97699-78-0
1,5-Naphthalenedisulfonic acid,3-(3-(p-butoxyphenyl)-2-thioureido)-, disodium salt 37556-91-5
2,7-Naphthalenedisulfonic acid,4-(2-carboxyphenylazo)-3-hydroxy-, trisodium salt 1836-22-2
2,7-Naphthalenedisulfonic acid,4-(4-chloro-6-ethylphenylamino-2-s-triazinylamino)-5-hydroxy-6-(4-methyl-2-sulfophenylazo)-, trisodiumsalt 73816-74-7
2,7-Naphthalenedisulfonic acid,5-((4-chloro-6-(phenylamino)-1,3,5-triazin-2-yl)amino)-4- hydroxy-3-((2-sulfophenyl)azo)-, trisodium salt 23211-47-4
1,5-Naphthalenedisulfonic acid, 3,?-diamino- 39699-08-6
3,6-Naphthalenedisulfonic acid,1,7-diamino-8-hydroxy- 3545-88-8
2,6-Naphthalenedisulfonic acid, 3,7-di-tert-butyl-,compd. with 6-(dimethylamino)-4,4-diphenyl-3-hexanone 103442-82-6
2,7-Naphthalenedisulfonic acid,3,3'-((3,3'-dichloro-4,4'-biphenylylene)bis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt 47897-65-4
2,7-Naphthalenedisulfonic acid,4-(4,6-dichloro-s-triazin-2-ylamino)-5-hydroxy-6-(2-hydroxy- 5-nitrophenylazo)- 73826-58-1
2,7-Naphthalenedisulfonic acid,5-(3,5-dichloro-s-triazinylamino)-4-hydroxy-3-phenylazo- 6522-86-7
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,2-(4-phenyl-1-piperazinyl)ethyl ester, (S)- 97699-76-8
2,7-Naphthalenedisulfonic acid,5-((4,6-dichloro-s-triazin-2-yl)amino)-4-hydroxy-3-(phenylazo)-, disodium salt 17804-49-8
1,5-Naphthalenedisulfonic acid,2-(6-(4,6-dichloro-s-triazinyl)methylamino-1-hydroxy-3- sulfonaphthylazo)- 73816-75-8
2,7-Naphthalenedisulfonic acid,4,5-dihydroxy-3-(phenylazo)-, disodium salt 4197-07-3
2,7-Naphthalenedisulfonic acid,3,3'-((3,3'-dimethoxy-4,4'-biphenylylene)bis(azo))bis( 5-amino-4-hydroxy-, tetrasodium salt 2429-74-5
6,8-Naphthalenedisulfonic acid,3,3'-((3,3'-dimethoxy-4,4'-biphenylene)bis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt 2610-05-1
1,3-Naphthalenedisulfonic acid,6,6'-((3,3'-dimethyl-4,4'-biphenylylene)bis(azo))bis(4-amino-5-hydroxy-, tetrasodium salt 314-13-6
2,7-Naphthalenedisulfonic acid,3,3'-((3,3'-dimethyl-4,4'-biphenylylene)bis(azo))bis(5- amino-4-hydroxy-, tetrasodium salt 72-57-1
1,3-Naphthalenedisulfonic acid,8-((3,3'-dimethyl-4'-((4-(((4-methylphenyl)sulfonyl)oxy) phenyl)azo)(1,1'-biphenyl)-4-yl)azo)-7-hydroxy-,disodium salt 6459-94-5
1,3-Naphthalenedisulfonic acid,8-((4'-((4-ethoxyphenyl)azo)-3,3'-dimethyl(1,1'-biphenyl)-4- yl)azo)-7-hydroxy-, disodium salt 6358-29-8
1,3-Naphthalenedisulfonic acid, 7-hydroxy-, disodiumsalt 842-19-3
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,(1,4-piperazinediyl)diethylene ester, (S-(R*,R*))- 97699-69-9
2,7-Naphthalenedisulfonic acid, 3-hydroxy-, disodiumsalt 135-51-3
2,7-Naphthalenedisulfonic acid,4-hydroxy-3-((4'-((2-hydroxy-1-naphthalenyl)azo)-2,2'- dimethyl(1,1'-biphenyl)-4-yl)azo)-, disodium salt 3701-40-4
2,6-Naphthalenedisulfonic acid,4-hydroxy-3-((2-methoxy-5-methylphenyl)azo)-,disodium salt 5864-85-7
1,3-Naphthalenedisulfonic acid,7-hydroxy-8-((4'-((4-(((4-methylphenyl)sulfonyl)oxy)phenyl) azo)(1,1'-biphenyl)-4-yl)azo)-, disodium salt 3567-65-5
2,7-Naphthalenedisulfonic acid,3-hydroxy-4-(1-naphthalenylazo)-, disodium salt 5858-33-3
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-nitroso-,disodium salt 525-05-3
2-Naphthalenesulfonic acid,4-hydroxy-3-((3-nitro-5-sulfophenyl)azo)-6-((3-((4-nitrophenyl) azo)-4,6-dihydroxyphenyl)azo)-, disodiumsalt 525-05-3
1,3-Naphthalenedisulfonic acid,7-hydroxy-8-(phenylazo)-, disodium salt 1936-15-8
2,7-Naphthalenedisulfonic acid,3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodiumsalt 2611-82-7
2,7-Naphthalenedisulfonic acid,3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodiumsalt 915-67-3

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