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MSDS  : 1,3-Naphthalenedisulfonic acid, 8-((3,3'-dimethyl-4'-((4-(((4-methylphenyl)sulfonyl)o xy) phenyl)azo)(1,1'-biphenyl)-4-yl)azo)-7-hydroxy-, disodium salt
CAS  : 6459-94-5
SYNONYMS  : * Acid Leather Red BG * Acid Red 114 * Amacid Milling Red PRS * Benzyl Fast Red BG * Benzyl Red BR * Cerven kysela 114 * C.I. 23635 * C.I. Acid Red 114 * C.I. Acid Red 114, disodium salt * Elcacid Milling Fast Red RS * Erionyl Red RS * Fenafor Red PB * Folan Red B * Intrazone Red BR * Kayanol Milling Red RS * Leather Fast Red B * Levanol Red GG * Midlon Red PRS * Milling Fast Red B * Milling Red B * Milling Red BB * Milling Red SWB * NCI C61096 * Polar Red RS * Sandolan Red N-RS * Sella Fast Red RS * Sulphonol Fast Red R * Sulphonol Red R * Suminol Milling Red RS * Supranol Fast Red 3G * Supranol Fast Red GG * Supranol Red PBX-CF * Supranol Red R * Telon Fast Red GG * Tetracid Milling Red B * Tetracid Milling Red G * Vondamol Fast Red RS
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : QJ6475500
CHEMICAL NAME : 1,3-Naphthalenedisulfonic acid,
8-((3,3'-dimethyl-4'-((4-(((4-methylphenyl)sulfonyl)o
xy) phenyl)azo)(1,1'-biphenyl)-4-yl)azo)-7-hydroxy-,
disodium salt
CAS REGISTRY NUMBER : 6459-94-5
LAST UPDATED : 199710
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C37-H28-N4-O10-S3.2Na
MOLECULAR WEIGHT : 830.85
WISWESSER LINE NOTATION : L66J BNUNR B1 DR C1 DNUNR DOSWR D1&&&& CQ HSWO JSWO
&-NA- 2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acid Leather Red BG
* Acid Red 114
* Amacid Milling Red PRS
* Benzyl Fast Red BG
* Benzyl Red BR
* Cerven kysela 114
* C.I. 23635
* C.I. Acid Red 114
* C.I. Acid Red 114, disodium salt
* Elcacid Milling Fast Red RS
* Erionyl Red RS
* Fenafor Red PB
* Folan Red B
* Intrazone Red BR
* Kayanol Milling Red RS
* Leather Fast Red B
* Levanol Red GG
* Midlon Red PRS
* Milling Fast Red B
* Milling Red B
* Milling Red BB
* Milling Red SWB
* NCI C61096
* Polar Red RS
* Sandolan Red N-RS
* Sella Fast Red RS
* Sulphonol Fast Red R
* Sulphonol Red R
* Suminol Milling Red RS
* Supranol Fast Red 3G
* Supranol Fast Red GG
* Supranol Red PBX-CF
* Supranol Red R
* Telon Fast Red GG
* Tetracid Milling Red B
* Tetracid Milling Red G
* Vondamol Fast Red RS

*** HEALTH HAZARD DATA ***

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26 gm/kg/13D-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NPT-TR-405,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10920 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-405,1991

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Skin and Appendages - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-405,1991

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 300 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,33,1984

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 125 ug/plate
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 22,413,1980

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,247,1993

IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,247,1993

IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,247,1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1427
No. of Facilities: 116 (estimated)
No. of Industries: 3
No. of Occupations: 14
No. of Employees: 2855 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1427
No. of Facilities: 331 (estimated)
No. of Industries: 9
No. of Occupations: 12
No. of Employees: 18511 (estimated)
No. of Female Employees: 352 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Carcinogenesis Studies (drinking);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-405,91


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy- 90-20-0
2,7-Naphthalenedisulfonic acid, 4-amino-3-hydroxy-,disodium salt 42579-07-7
2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-,disodium salt 3963-80-2
1,3-Naphthalenedisulfonic acid,4-amino-5-hydroxy-6-((4'-((2-hydroxy-1-naphthalenyl)azo)-3,3'-dimethoxy(1, 1'-biphenyl)-4-yl)azo)-,disodium salt 2586-57-4
2,7-Naphthalenedisulfonic acid,4-amino-5-hydroxy-6-((4'-((4-hydroxyphenyl)azo)(1,1'-biphenyl)-4-yl)azo)-3-((4-nitrophenyl)azo)-,disodium salt 4335-09-5
2,6-Naphthalenedisulfonic acid,4-amino-5-hydroxy-3-((4'-((4-hydroxyphenyl)azo)(1,1'-biphenyl)-4-yl)azo)-6-(phenylazo)-, disodium salt 3626-28-6
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,2-(4-nicotinoyl-1-piperazinyl) ethyl ester,dihydrochloride, (S)- 97699-66-6
2,7-Naphthalenedisulfonic acid,4-amino-5-hydroxy-3-((4-nitrophenyl)azo)-6-(phenylazo)-, disodium salt 1064-48-8
2,7-Naphthalenedisulfonic acid,4-amino-5-hydroxy-6-phenylazo-, disodium salt 3567-66-6
3,6-Naphthalenedisulfonic acid, 8-amino-7-hydroxy-,sodium salt 2007-20-7
2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-,p-toluenesulfonate (ester) 6837-93-0
2,7-Naphthalenedisulfonic acid,3-amino-4-((4'-((4-(((4-methylphenyl)sulfonyl)oxy)phenyl) azo)(1,1'-biphenyl)-4-yl)azo)-, disodium salt 2429-80-3
2,7-Naphthalenedisulfonic acid,4-((4-anilino-5-sulfo-1-naphthyl)azo)-5-hydroxy-,trisodium salt 3861-73-2
2,7-Naphthalenedisulfonic acid,3,3'-((4,4'-biphenylylene)bis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt 2602-46-2
1,5-Naphthalenedisulfonic acid,3-((p-(bis(2-chloroethyl)amino)phenyl)azo)- 101931-20-8
2,7-Naphthalenedisulfonic acid,3,6-(bis(4-((2-hydroxyethyl)sulfonyl)phenyl)bis(azo))- 5-amino-4-hydroxy-, di(hydrogen sulfate) ester,tetrasodium salt 17095-24-8
1,3-Naphthalenedisulfonic acid,7-(3-(p-butoxyphenyl)-2-thioureido)-, dipotassiumsalt 37556-92-6
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,2-(4-(1-oxo-3-phenyl-2-propenyl)-1- piperazinyl)ethylester, monohydrochloride, (S)- 97699-78-0
1,5-Naphthalenedisulfonic acid,3-(3-(p-butoxyphenyl)-2-thioureido)-, disodium salt 37556-91-5
2,7-Naphthalenedisulfonic acid,4-(2-carboxyphenylazo)-3-hydroxy-, trisodium salt 1836-22-2
2,7-Naphthalenedisulfonic acid,4-(4-chloro-6-ethylphenylamino-2-s-triazinylamino)-5-hydroxy-6-(4-methyl-2-sulfophenylazo)-, trisodiumsalt 73816-74-7
2,7-Naphthalenedisulfonic acid,5-((4-chloro-6-(phenylamino)-1,3,5-triazin-2-yl)amino)-4- hydroxy-3-((2-sulfophenyl)azo)-, trisodium salt 23211-47-4
1,5-Naphthalenedisulfonic acid, 3,?-diamino- 39699-08-6
3,6-Naphthalenedisulfonic acid,1,7-diamino-8-hydroxy- 3545-88-8
2,6-Naphthalenedisulfonic acid, 3,7-di-tert-butyl-,compd. with 6-(dimethylamino)-4,4-diphenyl-3-hexanone 103442-82-6
2,7-Naphthalenedisulfonic acid,3,3'-((3,3'-dichloro-4,4'-biphenylylene)bis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt 47897-65-4
2,7-Naphthalenedisulfonic acid,4-(4,6-dichloro-s-triazin-2-ylamino)-5-hydroxy-6-(2-hydroxy- 5-nitrophenylazo)- 73826-58-1
2,7-Naphthalenedisulfonic acid,5-(3,5-dichloro-s-triazinylamino)-4-hydroxy-3-phenylazo- 6522-86-7
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,2-(4-phenyl-1-piperazinyl)ethyl ester, (S)- 97699-76-8
2,7-Naphthalenedisulfonic acid,5-((4,6-dichloro-s-triazin-2-yl)amino)-4-hydroxy-3-(phenylazo)-, disodium salt 17804-49-8
1,5-Naphthalenedisulfonic acid,2-(6-(4,6-dichloro-s-triazinyl)methylamino-1-hydroxy-3- sulfonaphthylazo)- 73816-75-8
2,7-Naphthalenedisulfonic acid,4,5-dihydroxy-3-(phenylazo)-, disodium salt 4197-07-3
2,7-Naphthalenedisulfonic acid,3,3'-((3,3'-dimethoxy-4,4'-biphenylylene)bis(azo))bis( 5-amino-4-hydroxy-, tetrasodium salt 2429-74-5
6,8-Naphthalenedisulfonic acid,3,3'-((3,3'-dimethoxy-4,4'-biphenylene)bis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt 2610-05-1
1,3-Naphthalenedisulfonic acid,6,6'-((3,3'-dimethyl-4,4'-biphenylylene)bis(azo))bis(4-amino-5-hydroxy-, tetrasodium salt 314-13-6
2,7-Naphthalenedisulfonic acid,3,3'-((3,3'-dimethyl-4,4'-biphenylylene)bis(azo))bis(5- amino-4-hydroxy-, tetrasodium salt 72-57-1
1,3-Naphthalenedisulfonic acid,8-((3,3'-dimethyl-4'-((4-(((4-methylphenyl)sulfonyl)oxy) phenyl)azo)(1,1'-biphenyl)-4-yl)azo)-7-hydroxy-,disodium salt 6459-94-5
1,3-Naphthalenedisulfonic acid,8-((4'-((4-ethoxyphenyl)azo)-3,3'-dimethyl(1,1'-biphenyl)-4- yl)azo)-7-hydroxy-, disodium salt 6358-29-8
1,3-Naphthalenedisulfonic acid, 7-hydroxy-, disodiumsalt 842-19-3
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,(1,4-piperazinediyl)diethylene ester, (S-(R*,R*))- 97699-69-9
2,7-Naphthalenedisulfonic acid, 3-hydroxy-, disodiumsalt 135-51-3
2,7-Naphthalenedisulfonic acid,4-hydroxy-3-((4'-((2-hydroxy-1-naphthalenyl)azo)-2,2'- dimethyl(1,1'-biphenyl)-4-yl)azo)-, disodium salt 3701-40-4
2,6-Naphthalenedisulfonic acid,4-hydroxy-3-((2-methoxy-5-methylphenyl)azo)-,disodium salt 5864-85-7
1,3-Naphthalenedisulfonic acid,7-hydroxy-8-((4'-((4-(((4-methylphenyl)sulfonyl)oxy)phenyl) azo)(1,1'-biphenyl)-4-yl)azo)-, disodium salt 3567-65-5
2,7-Naphthalenedisulfonic acid,3-hydroxy-4-(1-naphthalenylazo)-, disodium salt 5858-33-3
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-nitroso-,disodium salt 525-05-3
2-Naphthalenesulfonic acid,4-hydroxy-3-((3-nitro-5-sulfophenyl)azo)-6-((3-((4-nitrophenyl) azo)-4,6-dihydroxyphenyl)azo)-, disodiumsalt 525-05-3
1,3-Naphthalenedisulfonic acid,7-hydroxy-8-(phenylazo)-, disodium salt 1936-15-8
2,7-Naphthalenedisulfonic acid,3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodiumsalt 2611-82-7
2,7-Naphthalenedisulfonic acid,3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodiumsalt 915-67-3

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