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MSDS  : 2-Naphthol, 1-((2,5-dimethoxyphenyl)azo)-
CAS  : 6358-53-8
SYNONYMS  : * Cerven rozpoustedlova 80 * C.I. 12156 * C.I. Solvent Red 80 * Citrus Red 2 * Citrus Red No. 2 * 2,5-Dimethoxybenzeneazo-beta-naphthol * 1-((2,5-Dimethoxyphenyl)azo)-2-naphthalenol * 1-(2,5-Dimethoxyphenylazo)-2-naphthol * 2,5-Dimethoxy-1-(phenylazo)-2-naphthol * 1-(1-(2,5-Dimethoxyphenyl)azo)-2-naphthol * 1-(2,5-Dimethyloxyphenylazo)-2-naphthol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : QL3675000
CHEMICAL NAME : 2-Naphthol, 1-((2,5-dimethoxyphenyl)azo)-
CAS REGISTRY NUMBER : 6358-53-8
BEILSTEIN REFERENCE NO. : 4510811
LAST UPDATED : 199701
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C18-H16-N2-O3
MOLECULAR WEIGHT : 308.36
WISWESSER LINE NOTATION : L66J BNUNR BO1 EO1& CQ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Cerven rozpoustedlova 80
* C.I. 12156
* C.I. Solvent Red 80
* Citrus Red 2
* Citrus Red No. 2
* 2,5-Dimethoxybenzeneazo-beta-naphthol
* 1-((2,5-Dimethoxyphenyl)azo)-2-naphthalenol
* 1-(2,5-Dimethoxyphenylazo)-2-naphthol
* 2,5-Dimethoxy-1-(phenylazo)-2-naphthol
* 1-(1-(2,5-Dimethoxyphenyl)azo)-2-naphthol
* 1-(2,5-Dimethyloxyphenylazo)-2-naphthol

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 46A,30,1969

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 542 gm/kg/31W-C
TOXIC EFFECTS :
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 46A,30,1969

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 125 gm/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in spleen weight
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 38B,46,1966

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 gm/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 4,493,1966

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
22,825,1968

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 67 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
19(Suppl 21),2,1992

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,101,1975

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,101,1975

IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

TOXICOLOGY REVIEW
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution
Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1-
1950- Volume(issue)/page/year: 13,271,1970

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4579
No. of Facilities: 16 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 980 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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