LD50 LC50 Mixture:ORAL LD50 (MOUSE): 790 MG/KG (SEE SUPP)
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:POLYMYXIN B
SULFATE-NEUROTOXICITY/NEPHROTOCICITY/NEUROMUSCULAR
BLOCKADE/SYSTEMIC POLYMYXIN POISONING/KIDNEY DAMAGE/SENSITIZATION.
NEOMYCIN SULFATE-SEVERE KIDNEY TOXICITY/NEUROTOXICITY/NEUROMUSCULAR
BL OCKADE/RESPIRATORY PARALYSIS. BACITRACIN
ZINC-IRRITATION/ALLERGIC REACTIONS/KIDNEY TOXICITY. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:POLYMYXIN B SULFATE-FEVER. NEOMYCIN
SULFATE-RASH, HEARING LOSS, DIMINISHED BALANCE. BACITRACIN
ZINC-IRRITATION. LIDOCAINE-IRRITATION.
======================= First Aid Measures =======================
Eyes: RINSE IMMEDIATELY W/PLENTY OF WATER. INHALATION: REMOVE
TO FRESH AIR. KEEP WARM & QUIET. GIVE CPR IF NEEDED. INGESTION:
WASH OUT MOUTH. GIVE PLENTY OF WATER/BLAND FLUIDS. UNLESS VOMITING
IS COPI OUS, LAVAGE SHOULD BE CARRIED OUT. SKIN: WASH OFF W/PLENTY
OF WATER. OBTAIN MEDICAL ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:USE AGENT APPROPRIATE TO NATURE OF FIRE & OTHER
MATERIALS INVOLVED.
Fire Fighting Procedures:WEAR SELF CONTAINED BREATHING APPARATUS.
Respiratory Protection:NONE NECESSARY.
Ventilation:NONE NECESSARY.
Protective Gloves:LATEX
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE.
Supplemental Safety and Health
ORAL LD50 INFORMATION IS FOR POLYMYXIN B SULFATE. HEALTH HAZARDS
CONT'D: LIDOCAINE-EYE/SKIN/RESPIRATORY TRACT IRRITATION, TOPICAL
ANESTHESIA. INGESTION IS TOXIC.
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.