MSDS NAME:AM0694 VINCRISTINE SULFATE FOR INJECTION 2 ML
NIIN:01-151-2341
MSDS Number: BWXTL
=== Responsible Party ===
Company:LILLY ELI & CO PHARMACEUTICAL DIV
Address:LILLY CORPORATE CENTER
City:INDIANAPOLIS
State:IN
ZIP:46285
Country:US
Info Phone Num:317-276-2000
Emergency Phone Num:317-276-2000
CAGE:GO399
=== Contractor Identification ===
Company:LILLY ELI & CO PHARMACEUTICAL DIV
Address:LILLY CORPORATE CENTER
City:INDIANAPOLIS
State:IN
ZIP:46285
Country:US
Phone:317-276-2000
CAGE:GO399
Company:LILLY ELI AND CO PHARMACEUTICAL DIV
Address:LILLY CORPORATE CENTER
Box:City:INDIANAPOLIS
State:IN
ZIP:46285
Country:US
Phone:317-276-2000
CAGE:75602
============= Composition/Information on Ingredients =============
Name:VINCRISTINE SULFATE (IARC GROUP 3) * 95-1 *
CAS:2068-78-2
RTECS #:OH6340000
Fraction by Wt: 9.1%
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:VINCRISTINE SULFATE- SKIN: IRRITANT.
EYES: SEVERE IRRITATION. PATIENTS TREATED W/COMBINATION THERAPY
HAVE DEVELOPED SECOND MALIGNANCIES/DECREASE IN FERTILITY. AT
INTRAVENOUS DOSES SUPPRESSES BONE MARR OW FUNCTION, WEAK IMMUNE
SUPPRESSION HAS OCCURED IN A FEW PATIENTS. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, DEPIGMENTATION, TEARING, PAIN,
BLURRED VISION, NAUSEA, VOMITING
Medical Cond Aggravated by Exposure:PATIENTS W/CHARCOT-MARIE-TOOTH
SYNDROME, WORKERS W/NEUROMUSCULAR DYSFUNCTION/SENSITIVITY TO
VINCRISTINE SULFATE.
======================= First Aid Measures =======================
Eyes: FLUSH W/A STEADY, GENTLE STREAM OF WATER FOR 15 MINS.
SKIN: WASH W/PLENTY OF SOAP & WATER. INHALATION: MOVE TO FRESH AIR.
IF NOT BREATHING, GIVE CPR. INGESTION: DON'T INDUCE VOMITING.
OBTAIN MED ICAL ATTENTION IN ALL CASES. NOTE TO PHYSICIAN: A
STEROID EYE OINTMENT/DROPS SERVE TO MINIMIZE INFLAMMATION.
===================== Fire Fighting Measures =====================
Unusual Fire/Explosion Hazard:MATERIAL MAY FORM DUST MIXTURES IN AIR &
EXPLODE IF SUBJECTED TO AN IGNITION SOURCE.
Spill Release Procedures:USE EITHER WET CLEANUP METHODS/VACUUM CLEANERS
W/HEPA FILTERS. USE DOUBLE PAIRS OF LATEX DISPOSABLE GLOVES
DISPOSING OF WITHIN AN HOUR, GOGGLES & NIOSH APPROVED DUST-MIST
RESPIRATOR.
Neutralizing Agent:MATERIAL MAY BE DECOMPOSED USING A BASIC (PH 10)
SODIUM HYPOCHLORIC SOLUTION.
====================== Handling and Storage ======================
Handling and Storage Precautions:VINCRISTINE SULFATE IS A CYTOTOXIC
MATERIAL.
Other Precautions:FOR WORK ENVIRONMENTS, EYE PROTECTION MUST BE
PROVIDED & HAND-TO-EYE CONTACT ELIMINATED. AVOID SKIN CONTACT.
Respiratory Protection:USE A NIOSH APPROVED DUST-MIST RESPIRATOR/SAFETY
EQUIPMENT. IN PRODUCTION SETTINGS, AIRLINE-SUPPLIED, HOOD-TYPE
RESPIRATORS ARE PREFERRED TO PROVIDE FACE/EYE & RESPIRATORY
PROTECTION.
Ventilation:EXTENSIVE LOCAL EXHAUST/ENCLOSED PROCESS EQUIPMENT
Protective Gloves:NATURAL RUBBER LATEX
Eye Protection:GOGGLES/FULL FACE MASK
Other Protective Equipment:IMPERVIOUS BODY COVERING; LONG SLEEVE
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE.
Supplemental Safety and Health
PH: 3.5-5.5 (RECONSTITUTED). HEALTH HAZ CONT'D: INHALATION-LOCAL
IRRITATION OF THE NOSE & THROAT. HOSPITAL EMPLOYEES & HEALTH CARE
PROVIDERS WHO PREPARE CYTOSTATIC DRUGS IN AN UNPROTECTED
ENVIRONMENT HAVE REPORTED HAVING INCREASED LEVELS OF MUTAGENS IN
THEIR URINE.
pH:(SUPP)
Solubility in Water:COMPLETE
Appearance and Odor:WHITE TO OFF-WHITE LYOPHILIZED PLUG W/NO ODOR
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:IGNITION SOURCES
Hazardous Decomposition Products:TOXIC FUMES WHEN HEATED TO
DECOMPOSITION
Waste Disposal Methods:PLACE RESIDUE IN A SEGREGATED, SEALED PLASTIC
CONTAINER. VINCA ALKALOIDS ARE BIODEGRADEABLE. DISPOSE RESIDUE
IAW/LOCAL, STATE& FEDERAL REGULATIONS. IF DISPOSED BY INCINERATION,
TEMP OF 850C FOR SOLIDS & TEMP OF 950C FOR LIQUIDS ARE REQUIRED.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.