LD50 LC50 Mixture:ORAL LD50 (RAT): 1500 MG/KG (SEE SUPP)
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:TRIMETHOPRIM-EXPOSURES IN EXCESS OF
THERAPEUTIC DOSAGE MAY CAUSE HEADACHE, MUSCULAR WEAKNESS & SWELLIN
IN CONTACT W/SKIN/SWALLOWED. IRRITATING TO EYES.
SULFAMETHOXAZOLE-OVEREXPOSURE HAS CAUSED GENERAL IZED ALLERGIC
REACTIONS INCLUDING SKIN RASH. HYSENSITIVITY TO SULFONAMIDES IS
POSSIBLE.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:TRIMETHOPRIM-EXPOSURES IN EXCESS OF THERAPEUTIC
DOSAGE MAY CAUSE HEADACHE, MUSCULAR WEAKNESS & SWELLING IN CONTACT
W/SKIN/SWALLOWED. SULFAMETHOXAZOLE-OVEREXPOSURE HAS CAUSED
GENERALIZED ALLERGIC REACT IONS INCLUDING SKIN RASH.
HYPERSENSITIVITY TO SULFONAMIDES IS POSSIBLE.
======================= First Aid Measures =======================
Eyes: RINSE W/PLENTY OF WATER. INGESTION: INDUCTION OF
EMESIS, GASTRIC ASPIRATION & LAVAGE & ADMINISTRATION OF CHARCOAL IS
RECOMMENDED. SKIN: WASH OFF W/PLENTY OF WATER. OBTAIN MEDICAL
ATTENTION IN AL L CASES.
===================== Fire Fighting Measures =====================
Spill Release Procedures:WEAR SUITABLE PROTECTIVE CLOTHING. WIPE/MOP UP
MATERIAL. TRANSFER TO CLOSED CONTAINER FOR DISPOSAL. SMALL: FLUSH
AWAY W/WATER. CLEAN AREA W/DETERGENT. WASH WATERS & RINSES SHOULD
BE DISCHARGED TO AN A PPROVED SEWERAGE SYSTEM.
====================== Handling and Storage ======================
Handling and Storage Precautions:KEEP IN ORIGINAL CONTAINER TIGHTLY
CLOSED.
Respiratory Protection:WEAR TOXIC DUST MASK.
Ventilation:LOCAL EXHAUST.
Protective Gloves:RUBBER/POLYVINYL CHLORINE
Eye Protection:SAFETY GLASSES/GOGGLES
Supplemental Safety and Health
MELTING POINT, SOLUBILITY IN WATER & ORAL LD50 INFORMATION IS FOR
TRIMETHOPRIM.
Melt/Freeze Pt:M.P/F.P Text:392F (SUPP)
Solubility in Water:0.04 MG/ML (SUPP)
Appearance and Odor:REFER TO PRODUCT INSERT FOR SPECIFIC PRODUCT
DESCRIPTION.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:TOXIC/IRRITANT FUMES.
Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.